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Compound famotidine calcium-magnesium chewable tablet and preparing method thereof

A famotidine and chewable tablet technology, applied in the field of medicine, can solve the problems of difficulty in compound chewable tablets, sensitivity to chemical stability of famotidine, etc.

Active Publication Date: 2015-09-16
YANTAI RONGCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In the above compound chewable tablets, in view of the amount of calcium carbonate in each tablet up to 800mg and the amount of magnesium hydroxide up to 165mg, and the amount of only famotidine 10mg, and the chemical stability of famotidine is relatively sensitive, Therefore, there are many technical difficulties in preparing this compound chewable tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Embodiment 1: Preparation of Famotidine Calcium and Magnesium Chewable Tablets

[0150] prescription:

[0151] Famotidine 10mg (feeding with clathrate 1),

[0152] Calcium Carbonate 800mg,

[0153] Magnesium hydroxide 165mg,

[0154] Beta cyclodextrin (feeding in the form of clathrate),

[0155] Mannitol 400mg,

[0156] Sucrose 400mg,

[0157] Sucralose 3mg,

[0158] Iced sweet orange powder essence 1mg,

[0159] Peppermint Powder Flavor 1mg,

[0160] Carmine Aluminum Lake 0.5mg,

[0161] Povidone K-30, 20mg (5% solution),

[0162] Magnesium stearate 15mg,

[0163] Silicon dioxide 10mg.

[0164] Preparation method:

[0165] (1) The adhesive is prepared into a solution for subsequent use;

[0166] (2) Pulverize famotidine-beta-cyclodextrin inclusion compound, calcium carbonate, magnesium hydroxide and other solid materials respectively, and pass through a 120-mesh sieve;

[0167] (3) Mix famotidine beta cyclodextrin inclusion compound, calcium carbonate, ...

Embodiment 2

[0169] Embodiment 2: Preparation of Famotidine Calcium and Magnesium Chewable Tablets

[0170] prescription:

[0171] Famotidine 10mg (feeding with clathrate 2),

[0172] Calcium Carbonate 800mg,

[0173] Magnesium hydroxide 165mg,

[0174] Beta cyclodextrin (feeding in the form of clathrate),

[0175] Mannitol 400mg,

[0176] Sucrose 400mg,

[0177] Sucralose 3mg,

[0178] Iced sweet orange powder essence 1mg,

[0179] Peppermint Powder Flavor 1mg,

[0180] Carmine Aluminum Lake 0.5mg,

[0181] Povidone K-30, 20mg (5% solution),

[0182] Magnesium stearate 15mg,

[0183] Silicon dioxide 10mg.

[0184] Preparation method:

[0185] (1) The adhesive is prepared into a solution for subsequent use;

[0186] (2) Pulverize famotidine-beta-cyclodextrin inclusion compound, calcium carbonate, magnesium hydroxide and other solid materials respectively, and pass through a 120-mesh sieve;

[0187] (3) Mix famotidine beta cyclodextrin inclusion compound, calcium carbonate, ...

Embodiment 3

[0189] Embodiment 3: Preparation of Famotidine Calcium Magnesium Chewable Tablets

[0190] prescription:

[0191] Famotidine 10mg (feeding with clathrate 3),

[0192] Calcium Carbonate 800mg,

[0193] Magnesium hydroxide 165mg,

[0194] Beta cyclodextrin (feeding in the form of clathrate),

[0195] Mannitol 400mg,

[0196] Sucrose 400mg,

[0197] Sucralose 3mg,

[0198] Iced sweet orange powder essence 1mg,

[0199] Peppermint Powder Flavor 1mg,

[0200] Carmine Aluminum Lake 0.5mg,

[0201] Povidone K-30, 20mg (5% solution),

[0202] Magnesium stearate 15mg,

[0203] Silicon dioxide 10mg.

[0204] Preparation method:

[0205] (1) The adhesive is prepared into a solution for subsequent use;

[0206] (2) Pulverize famotidine-beta-cyclodextrin inclusion compound, calcium carbonate, magnesium hydroxide and other solid materials respectively, and pass through a 120-mesh sieve;

[0207] (3) Mix famotidine beta cyclodextrin inclusion compound, calcium carbonate, and ...

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PUM

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Abstract

The invention relates to a compound famotidine calcium-magnesium chewable tablet and a preparing method thereof. The compound famotidine calcium-magnesium chewable tablet contains famotidine, calcium carbonate and magnesium hydrate. Specifically, the invention belongs to the medical technical field and relates to a drug combination for treating stomach diseases, in particular to a compound drug containing famotidine, calcium carbonate and magnesium hydrate, and further to a famotidine calcium-magnesium chewable tablet which has excellent pharmacy property and contains famotidine, calcium carbonate and magnesium hydrate. The famotidine calcium-magnesium chewable tablet not only has excellent pharmacy property, but also has excellent chemical stability. The famotidine calcium-magnesium chewable tablet can treat or prevent sour regurgitation, gastric acid excess, heartburn, stomachache, gasteremphraxis, belching and other stomach discomfort clinically. The invention further relates to the preparing method of the famotidine calcium-magnesium chewable tablet.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for treating stomach diseases, in particular to a compound pharmaceutical composition of famotidine (Famotidine), calcium carbonate, and magnesium hydroxide, and more particularly to a compound pharmaceutical composition with Chewable famotidine calcium magnesium tablets containing famotidine, calcium carbonate, and magnesium hydroxide with excellent pharmaceutical properties. The famotidine calcium magnesium chewable tablet of the present invention not only has excellent pharmacy properties, but also has excellent chemical stability. The famotidine calcium magnesium chewable tablet of the present invention can be used clinically for the treatment or prevention of acid reflux, gastric acid, heartburn (heartburn), gastric pain, gastric distension, belching and other stomach discomforts. Background technique [0002] Stomach disease is a very common dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/20A61P1/04A61P1/14A61P1/00A61K33/08A61K31/426
Inventor 熊晓滨张永光柳莉张丽
Owner YANTAI RONGCHANG PHARMA