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Preparation method of chitosan and montmorillonite compound drug carrying microsphere

A technology of drug-loaded microspheres and composite microspheres, which can be used in pharmaceutical formulations, medical preparations of inactive ingredients, and bulk delivery, etc., can solve problems such as insufficient mechanical properties and thermal stability, and achieve the ideal drug-loading and structure. Excellent, mechanically and thermally stable properties

Inactive Publication Date: 2014-08-06
SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
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Problems solved by technology

[0002] As a positively charged natural polymer, chitosan is abundant in reserves. It has good biocompatibility, degradability, antibacterial properties, non-toxicity, non-sensitization, non-mutagenicity, and promotes wound healing, etc. Features; In addition, chitosan can also be made into microspheres, scaffolds, nanoparticles, beads and nanofibers, etc., which make it have unique advantages in the field of drug carriers. Insufficient performance and thermal stability limit its practical application

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  • Preparation method of chitosan and montmorillonite compound drug carrying microsphere
  • Preparation method of chitosan and montmorillonite compound drug carrying microsphere
  • Preparation method of chitosan and montmorillonite compound drug carrying microsphere

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Embodiment Construction

[0016] The present invention will be described in further detail below in conjunction with the embodiments shown in the accompanying drawings.

[0017] The invention relates to preparing a novel chitosan / montmorillonite composite medicine-carrying microsphere by using chitosan as the main raw material and calcium-based montmorillonite as an auxiliary material under microwave radiation and ion cross-linking method. The main preparation process: Weigh a certain amount of chitosan (deacetylation degree is 80.0 %~95.0 %) and dissolve it in 50~100 ml of acetic acid solution with a volume fraction of 2~3 % to prepare 1~2 % (w / v) chitosan acetate solution. Then remove impurities in the chitosan by suction filtration for subsequent use. Then weigh quantitative pharmaceutical grade calcium-based montmorillonite (montmorillonite content greater than 99%) and disperse it in 100-200 ml deionized water, and mechanically stir for 8-10 h to prepare montmorillonite suspension. At room temp...

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Abstract

The invention relates to a preparation method of a drug carrying microsphere, particularly to a preparation method of chitosan and montmorillonite compound drug carrying microsphere. The preparation method comprises the following steps: firstly, weighing quantitative chitosan, dissolving the chitosan into 50-100 ml of acetum to prepare a 1-2% (w / v) chitosan acetum, wherein the degree of deacetylation of the chitosan is 80.0-95.0%, the volume fraction of the acetum is 2-3%; weighing and dispersing quantitative officinal calcium-based montmorillonite into 100-200 ml of deionized water, setting relevant parameters in a microwave reactor, dropwise adding 0.5-0.8 g / l sodium pyrophosphate into a prepared chitosan / montmorillonite mixed solution to obtain a chitosan / montmorillonite compound microsphere solution, wherein the content of the montmorillonite is greater than 99%; finally freeze-drying the chitosan / montmorillonite compound microsphere solution. According to the invention, chitosan / montmorillonite compound microsphere is used as a carrier for preparing a lung targeted drug, environmentally friendly, non-toxic, simple in preparation processes and low in preparation cost, and has the characteristics of high mechanical and thermal stabilities, excellent dispersity and structure, and ideal medicine carrying.

Description

technical field [0001] The invention relates to a preparation method of drug-loaded microspheres, in particular to a preparation method of chitosan and montmorillonite composite drug-loaded microspheres. Background technique [0002] As a positively charged natural polymer, chitosan is abundant in reserves. It has good biocompatibility, degradability, antibacterial properties, non-toxicity, non-sensitization, non-mutagenicity, and promotes wound healing, etc. Features; In addition, chitosan can also be made into microspheres, scaffolds, nanoparticles, beads and nanofibers, etc., which make it have unique advantages in the field of drug carriers. Insufficient performance and thermal stability limit its practical application. [0003] Montmorillonite is a layered silicate mineral with good water swelling, suspension, dispersion, cohesiveness, thixotropy, adsorption, ion exchange and stable mechanical properties. Pharmacological studies of montmorillonite show that , It has a...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61K47/04
Inventor 刘学贵宋林高品一王基林张振学
Owner SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
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