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Preparation method of a multi-responsive polymer hollow microgel

A responsive polymer technology, applied in the field of materials, can solve the problems of complex preparation process and high energy consumption, and achieve the effects of low viscosity, fast heat transfer, and reduced energy consumption

Active Publication Date: 2017-05-24
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a method for preparing a multi-responsive polymer hollow microgel with good biocompatibility, aiming to overcome the disadvantages of complicated preparation process and high energy consumption

Method used

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  • Preparation method of a multi-responsive polymer hollow microgel
  • Preparation method of a multi-responsive polymer hollow microgel
  • Preparation method of a multi-responsive polymer hollow microgel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 0.1g sodium chloride and 0.1g reducing initiator TEPA and dissolve in 8.0g deionized water, then add 0.2g crosslinking agent MBA and 1.5g monomer N-vinylcaprolactam (NVCL), and stir magnetically for 30min to make it fully mixed as the aqueous phase;

[0045] Weigh 45g of toluene and 2.4g of emulsifier SPAN-80, and magnetically stir for 15min to mix them evenly as the oil phase.

[0046] The oil phase was slowly added to the water phase and stirred magnetically for 15 minutes to form a pre-emulsion, and then homogeneously emulsified in an ice-water bath at a speed of 16,000 rpm for 5 minutes to obtain a stable inverse miniemulsion.

[0047] The inverse miniemulsion prepared above was added into a three-necked flask equipped with mechanical stirring, a thermometer and a reflux condensing device. After stirring nitrogen for 30 minutes, the water bath was heated to 50 ° C, and 0.2 g of oxidation initiator CHPO (dissolved in a small amount of toluene) was added to the...

Embodiment 2

[0049] Weigh 1.5g of monomeric N-vinyl caprolactam (NVCL) and 0.5g of monomeric methacrylic acid (MAA) and mix them thoroughly. The above-mentioned mixed monomers, 0.1g of sodium chloride and 0.1g of reducing initiator TEPA are dissolved in 8.0 Add 0.2 g of cross-linking agent MBA to 1 g of deionized water, stir magnetically for 30 minutes to fully mix it as the water phase; weigh 45 g of toluene and 2.4 g of emulsifier SPAN-80, stir magnetically for 15 minutes to mix evenly as the oil phase.

[0050] The oil phase was slowly added to the water phase and stirred magnetically for 15 minutes to form a pre-emulsion, and then homogeneously emulsified in an ice-water bath at a speed of 16,000 rpm for 5 minutes to obtain a stable inverse miniemulsion.

[0051] The inverse miniemulsion prepared above was added into a three-necked flask equipped with mechanical stirring, a thermometer and a reflux condensing device. After stirring nitrogen for 30 minutes, the water bath was heated to ...

Embodiment 3

[0054] Take by weighing 1.5g monomer N-vinyl caprolactam (NVCL) and 0.5g monomer methacrylic acid (MAA) and fully mix, mix above-mentioned mixed monomer, 0.1g sodium chloride, 0.1g reducing initiator TEPA, and 0.3 g Hydrophilic Fe 3 o 4 Dissolve magnetic nanoparticles in 8.0g deionized water, then add 0.2g cross-linking agent MBA, stir magnetically for 30min to make it fully mixed as the water phase;

[0055] Weigh 45g of toluene and 2.4g of emulsifier SPAN-80, and magnetically stir for 15min to mix them evenly as the oil phase.

[0056] The oil phase was slowly added to the water phase and stirred magnetically for 15 minutes to form a pre-emulsion, and then homogeneously emulsified in an ice-water bath at a speed of 16,000 rpm for 5 minutes to obtain a stable inverse miniemulsion.

[0057] The miniemulsion prepared above was added into a three-necked flask equipped with mechanical stirring, a thermometer and a reflux condensation device. After stirring nitrogen for 30 minu...

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Abstract

The invention discloses a preparation method of a multi-responsive polymer hollow microgel, which comprises the following steps: a water-soluble temperature-sensitive monomer, a pH-sensitive monomer, sodium chloride, a cross-linking agent, a reduction initiator and The hydrophilic Fe3O4 magnetic nanoparticles form a dispersed phase, which is a continuous phase composed of a hydrophobic solvent and an emulsifier; the dispersed phase is added to the continuous phase to obtain a pre-emulsion; the pre-emulsion is dispersed homogeneously at high speed to prepare an inverse miniemulsion; Under the action of the redox-triggered system, the inverse miniemulsion is polymerized to prepare the multi-responsive polymer hollow microgel. The monomer involved in the present invention is a hydrophilic monomer, and the reverse phase miniemulsion polymerization process is adopted to coat the hydrophilic magnetic nanoparticles on the microgel shell, so that the microgel has more excellent magnetic responsiveness. Redox trigger system, the prepared microgel has a good hollow structure, and has good biocompatibility, temperature and pH responsiveness, and has broad application prospects in the field of biological and medical materials.

Description

technical field [0001] The invention belongs to the field of material technology, and specifically relates to a method for preparing a polymer hollow microgel with pH, ​​temperature and magnetic responsiveness formed by copolymerizing a water-soluble thermosensitive monomer as a main monomer and adding a second monomer. Background technique [0002] Microgel, which belongs to nano-micron-scale gel particles, is a polymer particle with an intramolecular cross-linked structure, with a size between 1 and 1000nm. It has dual properties of hydrogel and micellar particles. It swells but does not dissolve, and has strong expansion-contraction properties. Environmentally responsive microgel refers to a polymer gel that can sense small changes or stimuli in the external environment (such as temperature, pH, magnetic field, etc.), and can produce corresponding changes in physical structure and chemical properties. Environmental responsiveness makes it show a wide range of application...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F226/06C08F220/06C08F4/40C08K3/22
Inventor 张建安吴庆云吴明元杨建军谭深宋媛媛
Owner ANHUI UNIVERSITY
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