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Solventing-out crystallization process of paeonol

A technology of dissolution crystallization and paeonol, which is applied in the field of paeonol dissolution crystallization technology, can solve the problems of high equipment requirements and large energy consumption, and achieve the effect of simple equipment, low cost, and easy popularization and application

Inactive Publication Date: 2015-11-04
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most pharmaceutical factories obtain high-purity paeonol products through freezing and crystallization. This method not only requires a lot of energy consumption, but also requires high equipment

Method used

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  • Solventing-out crystallization process of paeonol
  • Solventing-out crystallization process of paeonol
  • Solventing-out crystallization process of paeonol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A kind of dissolution and crystallization process of paeonol, the process is paeonol mother liquor in the ratio of parts by weight: solvent: dissolution agent=20:10:10 ratio, wherein solvent is 75% ethanol solution, dissolution agent It is water; with solvent as base material, under the state of stirring at a stirring rate of 80r / min, add molten paeonol mother liquor, and dropwise add eluting agent at a rate of 1mL / min, and continue stirring for 110min at normal temperature; Filter and dry to obtain the crystallization product of paeonol mother liquor.

Embodiment 2

[0069] A kind of dissolution and crystallization process of paeonol, this process is the ratio of paeonol mother liquor by weight and number: solvent: dissolving agent=30:20:15 ratio, wherein solvent is 75% ethanol solution, dissolving agent It is water; with solvent as base material, under the state of stirring at a stirring rate of 120r / min, add the molten paeonol mother liquor, and dropwise add the dissolution agent at a rate of 3mL / min, and continue stirring for 200min at normal temperature; Filter and dry to obtain the crystallization product of paeonol mother liquor.

Embodiment 3

[0071] A kind of dissolution and crystallization process of paeonol, this process is the ratio of paeonol mother liquor by weight and number: solvent: dissolving agent=25:15:12 ratio, wherein solvent is 75% ethanol solution, dissolving agent It is water; with the solvent as the bottom material, under the stirring state of 100r / min, the molten paeonol mother liquor is added, and the dissolution agent is added dropwise at a rate of 2mL / min, and the stirring is continued at normal temperature for 150min; Filter and dry to obtain the crystallization product of paeonol mother liquor.

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Abstract

The invention discloses a solventing-out crystallization process of paeonol, and relates to a crystallization process of a drug component; the process comprises the steps: according to the weight part ratio of a paeonol mother liquor to a solvent to a solventing-out agent of (20-30) to (10-20) to (10-15), with the solvent as a backing material, under a stirring condition of keeping the stirring speed at 80-120 r / min, adding the fused paeonol mother liquor, dropwise adding the solventing-out agent at a speed of 1-3 mL / min, and continuously stirring for 110-200 min at room temperature; and carrying out suction filtration, drying, and thus obtaining a paeonol mother liquor solventing-out crystallization product. The solvent is a 75% ethanol solution, and the solventing-out agent is water. The solventing-out crystallization process has no need of freezing crystallization, is low in energy consumption, simple in device and high in product purity which can reach 99.00%-99.78%, conforms to factory leaving requirements, and is prone to popularization and application in pharmaceutical industries.

Description

technical field [0001] The invention relates to a crystallization process of pharmaceutical components, in particular to a dissolution and crystallization process of paeonol. Background technique [0002] Paeonol, 2-hydroxy-4-methoxy-acetophenone, white or yellowish shiny needle crystal, easily soluble in ethanol and methanol, slightly soluble in water, dissolved in hot water , insoluble in cold water. Paeonol can be distilled with water vapor and has strong absorption in the ultraviolet region. Paeonol has anti-allergy and anti-inflammation, cardiovascular protection, neuroprotection, anti-tumor, prevention of diabetes, anti-microbial infection and various pharmacological effects. It is mainly used for the treatment of rheumatism, stomach pain, eczema, and allergic dermatitis. [0003] The crystallization process is a very complicated process of mass transfer, heat transfer and surface reaction. Crystallization thermodynamic properties such as solute solubility and metast...

Claims

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Application Information

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IPC IPC(8): C07C49/84C07C45/81
CPCC07C45/81
Inventor 姚志湘粟晖潘小慧陆丹梅董金梅闫一夫
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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