Iridoid compounds in lonicera japonica, preparation method therefor and use thereof

The technology of iridoid glycosides and compounds is applied in the field of medicine and can solve the problems of damage to body functions, large side effects and adverse reactions, etc., and achieve the effects of good hypoglycemic activity, simple preparation method and good reproducibility.

Active Publication Date: 2015-11-04
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of some α-glucosidase inhibitors will cause an excessive economic burden to patients, and the most important thing is that their side effects are relatively large, causing serious damage to other human body functions, such as intestinal disorders such as diarrhea

Method used

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  • Iridoid compounds in lonicera japonica, preparation method therefor and use thereof
  • Iridoid compounds in lonicera japonica, preparation method therefor and use thereof
  • Iridoid compounds in lonicera japonica, preparation method therefor and use thereof

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Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0045]Take 10 kg of dried honeysuckle flower buds and decoct them with water for 3 times, 6 hours each time, the ratio of medicinal materials to water is: 1:3, and the combined extracts are concentrated to obtain extracts. The extracts adopt macroporous adsorption column chromatography, and ethanol - The water system eluted gradually at 0:100, 15:85, 30:70, 50:50, and 100:0. A total of 12 fractions were collected, detected by silica gel thin layer chromatography, and combined into A1~A4, A2 (350g ) by polyamide column chromatography, using pure water as the mobile phase elution, the eluent obtained B after vacuum distillation, and B was quickly decompressed column chromatography with dichloromethane-methanol-water system 50:1:0.01, 20 :1:0.01, 10:1:0.01, 5:1:0.01, 1:1:0.01 gradient elution, a total of 35 fractions were obtained, which were detected by silica gel thin layer plate chromatography and combined into C1~C5, and C1 was obtained by ODS column chromatography was eluted...

preparation Embodiment 2

[0047] Take 12 kg of dried honeysuckle flower buds and decoct them with water to extract 4 times, each time for 10 hours, the ratio of medicinal materials to water is: 1:4, and the combined extracts are concentrated to obtain extracts. - The water system eluted gradually at 0:100, 15:85, 30:70, 60:40, and 100:0. A total of 10 fractions were collected, detected by silica gel thin layer chromatography, and combined into A1~A4, A2 (400g ) by polyamide column chromatography, using pure water as the mobile phase elution, the eluent obtained B after vacuum distillation, and B was quickly decompressed column chromatography with dichloromethane-methanol-water system 50:1:0.01, 20 :1:0.01, 15:1:0.01, 8:1:0.01, 3:1:0.01, 1:1:0.01 gradient elution, a total of 25 fractions were obtained, which were identified by silica gel thin layer plate chromatography and combined into C1~C5, C1 obtained 26 fractions by ODS column chromatography with methanol-water system 10:90, 35:65, 50:50, 0:100, gr...

preparation Embodiment 3

[0049] Take 11 kg of dried honeysuckle flower buds and decoct them with water to extract twice, each time for 7 hours, the ratio of medicinal materials to water is: 1:3, and the combined extracts are concentrated to obtain extracts. - The water system was eluted gradually at 0:100, 15:85, 40:60, 70:30, and 100:0. A total of 11 fractions were collected and identified by silica gel thin-layer chromatography. They were combined into A1~A4, A2 (450g ) by polyamide column chromatography, using pure water as the mobile phase elution, the eluent obtained B after vacuum distillation, and B was quickly decompressed column chromatography with dichloromethane-methanol-water system 50:1:0.01, 20 :1:0.01, 10:1:0.01, 5:1:0.01, 3:1:0.01, 1:1:0.01 gradient elution, a total of 40 fractions were obtained, which were identified by silica gel thin layer plate chromatography and combined into C1~C5, C1 obtained 24 fractions by ODS column chromatography with methanol-water system 10:90, 25:75, 55:4...

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Abstract

The present invention belongs to the field of medical technology, and relates to a series of new iridoid compounds Loniceranan A, Loniceranan B, and Loniceranan C extracted and separated from dried buds of caprifoliaceae plants lonicera japonica, wherein the compounds comprise the same secoiridoid glucoside nucleus. The present invention also relates to the new compounds, hypoglycemic physiological activity of drugs prepared by using the compounds, and medical applications of the compounds . The compounds may be combined with a pharmaceutically acceptable carrier to form a clinically acceptable dosage form to be used for treatment of various diabetes. The preparation method of the present invention is simple and good in reproducibility, and the compounds are high in purity. The compounds obtained have good hypoglycemic activity.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to iridoid glycoside compounds in honeysuckle and a preparation method thereof, and also relates to the application of the new compounds in the preparation of hypoglycemic drugs. Background technique: [0002] Diabetes stems from insufficient insulin secretion in the human body, which leads to systemic diseases mainly caused by disordered glucose metabolism, and is accompanied by a series of complications in the body. It is difficult to cure and has a serious impact on the lives of patients. Diabetes is one of the most common epidemic diseases in the world, and its mortality rate is second only to cardiovascular diseases and malignant tumors in developed countries, becoming the third cause of death. α-glucosidase inhibitors (such as acarbose) are often used clinically as antidiabetic drugs, they can improve vascular permeability and lower blood sugar levels. However, long-term use ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P3/10
Inventor 宋少江彭缨刘志翔李玲芝刘庆博黄肖霄
Owner SHENYANG PHARMA UNIVERSITY
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