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Preparation method for biomass charcoal anti-schistosoma cercaria slow-release pharmaceutical preparation

A technology of biomass charcoal and slow-release drugs, which is applied in the fields of botanical equipment and methods, biocides, chemicals for biological control, etc. and other problems to achieve the effect of increasing the action time, solving environmental problems, and improving the efficiency of drug use

Inactive Publication Date: 2015-11-11
GANNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of the current anti-schistosome cercariae drugs, such as large dosage, low solubility and short drug action time, the invention provides a long-acting slow-release anti-schistosome cercariae preparation by utilizing the adsorption performance of solid waste carbonized materials preparation method

Method used

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  • Preparation method for biomass charcoal anti-schistosoma cercaria slow-release pharmaceutical preparation
  • Preparation method for biomass charcoal anti-schistosoma cercaria slow-release pharmaceutical preparation
  • Preparation method for biomass charcoal anti-schistosoma cercaria slow-release pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Select bamboo powder as carbonization raw material

[0052] a) Take 50 mg of bamboo powder biomass raw material in a 15 mL crucible, place it in a tube furnace, and carry out high-temperature pyrolysis carbonization under the protection of nitrogen. The carbonization temperature range is 350-1000 ° C, and the carbonization retention time is 1 hour. The yield of biochar obtained at different temperatures was calculated, and it was found that the higher the temperature, the lower the yield of carbonization, and the optimal carbonization temperature was selected to be 500-700°C.

[0053] b) Using a scanning electron microscope to characterize the surface morphology of the biochar material obtained in step a), such as figure 1 It was shown that with the increase of temperature, more and more pores were formed on the surface of bamboo powder.

[0054] c) Using a nitrogen adsorption-desorption tester to perform micro-mesoporous characterization of the bamboo powder carbon m...

Embodiment 2

[0058] Select poplar as carbonization raw material

[0059] a) Take 500 mg of poplar biomass raw material in a 15 mL crucible, place it in a tube furnace, and carry out high-temperature pyrolytic carbonization under the protection of nitrogen. The carbonization temperature range is 350-1000 ° C, and the carbonization retention time is 1 hour. The yield of biochar obtained at different temperatures was calculated, and it was found that the higher the temperature, the lower the yield of carbonization, and the optimal carbonization temperature was selected to be 500-700°C.

[0060] b) Using a scanning electron microscope to characterize the surface morphology of the biochar material obtained in step a), such as figure 2 shown.

[0061] c) Using a nitrogen adsorption-desorption tester to perform micro-mesoporous characterization of the poplar carbon material obtained by carbonization at 600°C for 1 hour, the data was calculated by the Brunauer-Emmett-Teller method to obtain a sp...

Embodiment 3

[0065] Choose tung tree as carbonization raw material

[0066] a) Take 500mg of tung tree biomass raw material in a 15mL crucible, place it in a tube furnace, and carry out high-temperature pyrolytic carbonization under the protection of nitrogen. The carbonization temperature range is 350-1000°C, and the carbonization retention time is 1 hour. The yield of biochar obtained at different temperatures was calculated, and it was found that the higher the temperature, the lower the yield of carbonization, and the optimal carbonization temperature was selected to be 500-700°C.

[0067] b) Using a scanning electron microscope to characterize the surface morphology of the biochar material obtained in step a), such as image 3 shown.

[0068] c) Micro-mesoporous characterization of the tung tree biochar material obtained by carbonization at 600°C for 1 hour using a nitrogen adsorption-adsorption-desorption tester, and the specific surface area of ​​the material was calculated by the ...

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Abstract

The invention relates to a preparation method for a biomass charcoal anti-schistosoma cercaria slow-release pharmaceutical preparation. The preparation method comprises the following procedures: selecting the biomass of duckweed, poplar, vernicia fordii, bamboo powder and styphnolobium japonicum as carbonization materials; carrying out carbonization at 350-1000 DEG C to obtain appropriate biomass charcoal materials of which the specific surface area is 5-500 m<2> / g and the pore diameter is 0.5-10 nm; conducting functional group, surface appearance and specific surface area representation on the biomass charcoal materials; carrying out synthesis to obtain an anti-schistosoma cercaria pharmaceutical polyether benzamide; selecting the carbonized materials of bamboo powder, poplar and vernicia fordii as slow-release carriers of the anti-schistosoma cercaria pharmaceutical polyether benzamide, and measuring the release kinetic curve of polyether benzamide with the ultraviolet absorption spectrum; carrying out cercaria killing experiments. The preparation method has the advantages that the carbonized materials of bamboo powder, poplar and vernicia fordii are selected as the slow-release carriers of the anti-schistosoma cercaria pharmaceutical, so that the release speed of the pharmaceutical polyether benzamide can be slowed down, the slow-release period lasts for 4 days or longer, and the cercaria killing effect reaches 95% or above.

Description

technical field [0001] The invention belongs to the technical field of new dosage forms and preparations of parasite prevention and control drugs. More specifically, the invention uses solid waste carbonized materials to load anti-schistosomiasis cercariae drugs to prepare preparations with long-acting and slow-release performance. Compared with previous anti-schistosome cercariae drugs , this type of sustained-release pharmaceutical preparation has the advantages of solid waste recycling and long drug sustained-release time. Background technique [0002] Schistosomiasis is a major infectious disease prevalent in tropical and subtropical regions, seriously endangering people's health and affecting economic and social development. Nearly 200 million people around the world have been infected, covering 76 countries and regions, and the number of people living in endemic areas threatened by infection has reached 779 million. It is listed by the World Health Organization as an e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N37/22A01P15/00
Inventor 范小林吴勇权吴任苗曾冠杰李亿保
Owner GANNAN NORMAL UNIV
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