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Pharmaceutical composition of hyaluronic acid modified magnetic hollow mesoporous copper sulfide as well as preparation method and application of pharmaceutical composition

A hyaluronic acid-modified, mesoporous copper sulfide technology, applied in the field of medicine, can solve the problems of dose-limiting toxicity, poor chemotherapy targeting, and difficult to remove subclinical lesions, and achieves stable and reliable method, small toxic and side effects, and magnetic targeting. strong effect

Inactive Publication Date: 2015-11-18
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgery can only remove tumors that are visible to the naked eye, but it is difficult to remove invisible subclinical lesions; traditional chemotherapy often has the problems of poor targeting and dose-limiting toxicity; new treatments for

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] In the specific implementation of the present invention, the preparation method of the pharmaceutical composition of magnetic hollow mesoporous copper sulfide modified by hyaluronic acid is realized by the following method:

[0018] (1), 0.75g of CuSO 4 ·5H 2 Dissolve O in 200ml water, stir, add 6.0g polyvinylpyrrolidone, react for 10~20min, add 1.2g sodium hydroxide, stir evenly, add 12ml hydrazine hydrate dropwise with a syringe, stir for 5~10min, finally add 1.29ml ammonium sulfate , stirred for 1 hour, washed with ultrapure water for 15000 rpm for 5-10 minutes to neutrality, and freeze-dried for 48 hours to obtain hollow mesoporous copper sulfide nanoparticles;

[0019] (2) Ultrasonically disperse hollow mesoporous copper sulfide nanoparticles 100mg probe in 100ml ultrapure water, ultrasonic for 10~30min, add 200mg of mercaptoethylamine under stirring condition, stir for 24h, centrifuge at 15000rpm for 5-10min to get precipitate, add super Redissolve in pure water...

Embodiment 2

[0025] In the specific implementation of the present invention, the preparation method of the pharmaceutical composition of magnetic hollow mesoporous copper sulfide modified by hyaluronic acid is realized by the following method:

[0026] (1), 0.7g of CuSO 4 ·5H 2 Dissolve O in 180ml of water, stir, add 5g of polyvinylpyrrolidone, react for 10~20min, add 1.1g of sodium hydroxide, stir evenly, then add dropwise 11ml of hydrazine hydrate, stir for 5~10min, add 1.2ml of ammonium sulfate, stir for 1h, Centrifuge with ultrapure water at 12000rpm for 10min and wash until neutral, freeze-dry for 48h to obtain hollow mesoporous copper sulfide nanoparticles;

[0027] (2) Ultrasonically disperse 90mg of hollow mesoporous copper sulfide nanoparticles in 90ml of ultrapure water, ultrasonically for 10~30min, add 180mg of mercaptoethylamine under stirring, stir for 24h, centrifuge at 12000rpm for 10min to obtain a precipitate, add ultrapure water to the precipitate and then centrifuged a...

Embodiment 3

[0033] In the specific implementation of the present invention, the preparation method of the pharmaceutical composition of magnetic hollow mesoporous copper sulfide modified by hyaluronic acid is realized by the following method:

[0034] (1) Add 0.8g of CuSO 4 ·5H 2 Dissolve O in 220ml of water, stir, add 7g of polyvinylpyrrolidone, react for 10~20min, add 1.3g of sodium hydroxide, stir evenly, then add dropwise 13ml of hydrazine hydrate, stir for 5~10min, add 1.4ml of ammonium sulfate, stir for 1h, Centrifuge with ultrapure water at 13000rpm for 8min and wash until neutral, freeze-dry for 48h to obtain hollow mesoporous copper sulfide nanoparticles;

[0035] (2) Ultrasonically disperse 110 mg of hollow mesoporous copper sulfide nanoparticles in 110 ml of ultrapure water, ultrasonicate for 10-30 minutes, add 220 mg of mercaptoethylamine under stirring, stir for 24 hours, centrifuge at 13000 rpm for 8 minutes to obtain a precipitate, add ultrapure water to the precipitate T...

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Abstract

The invention relates to a pharmaceutical composition of hyaluronic acid modified magnetic hollow mesoporous copper sulfide as well as a preparation method and application of the pharmaceutical composition; the pharmaceutical composition is capable of effectively solving the problems of guaranteeing good biocompatibility, strong magnetic targeting and low toxic and side effects so as to enhance a tumor treatment effect. The preparation method comprises the following steps: loading an antineoplastic drug on aminated copper sulfide obtained from a reaction between hollow mesoporous copper sulfide nanoparticles and mercaptoethylamine; adsorbing ferroferric oxide nanoparticles to the surface of the copper sulfide through an electrostatic effect; and modifying hyaluronic acid on the surface through an amide bond reaction, so as to obtain the pharmaceutical composition of hyaluronic acid modified magnetic hollow mesoporous copper sulfide, wherein the mass content ratio of the ferroferric oxide to the copper sulfide is at (1-8): 1; and the grain size of the magnetic hollow mesoporous copper sulfide is 50-300nm. The preparation method disclosed by the invention is convenient in operation, and is stable and reliable; the pharmaceutical composition has the advantages of good biocompatibility, strong magnetic targeting, low toxic and side effects and the like; and the pharmaceutical composition can take the effects of thermal therapy, tumor diagnosis, magnetic field sustained and controlled drug release and the like in the aspect of tumor treatment.

Description

technical field [0001] The invention relates to medicine, in particular to a pharmaceutical composition of magnetic hollow mesoporous copper sulfide modified by hyaluronic acid, a preparation method and application thereof. Background technique [0002] Surgery, radiotherapy, and chemotherapy are the three most commonly used means of tumor treatment. However, surgery can only remove tumors that are visible to the naked eye, but it is difficult to remove invisible subclinical lesions; traditional chemotherapy often has the problems of poor targeting and dose-limiting toxicity; new treatment methods. Photothermal therapy technology is a minimally invasive technology that uses photothermal conversion materials to convert the energy of near-infrared light into heat energy. Photothermal therapy can achieve local heating and kill cancer cells in the treatment of cancer, but it has no effect on normal cells. Damage is a safer and more efficient means of tumor treatment. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/48A61K31/704A61K41/00A61P35/00A61K49/00A61K47/61A61K47/69
Inventor 冯倩华侯琳张振中张媛媛张红岭
Owner ZHENGZHOU UNIV
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