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Levodropropizine inclusion compound dispersible tablet and preparation method thereof

A levodropropizine and clathrate technology, which is applied in the field of levodropropizine clathrate dispersible tablets and its preparation, can solve problems such as poor taste and reduced bitterness, and achieve reasonable formula, improved taste and stable process Effect

Active Publication Date: 2018-09-18
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: provide a kind of levodropropizine clathrate dispersible tablet and preparation method thereof, it can overcome the shortcoming of existing levodropropizine preparation poor mouthfeel, make its bitterness significantly reduce, and The production process is simple and the cost is low, so as to overcome the deficiencies of the prior art

Method used

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  • Levodropropizine inclusion compound dispersible tablet and preparation method thereof
  • Levodropropizine inclusion compound dispersible tablet and preparation method thereof
  • Levodropropizine inclusion compound dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052]Embodiment 1: levodropropizine inclusion compound dispersible tablet,

[0053] Levodropropizine clathrate: the mol ratio of β-cyclodextrin is 1:1;

[0054] The prescription of dispersible tablets is (calculated by mass percentage):

[0055] Levodropropizine-β-cyclodextrin inclusion complex 4g

[0056] L-HPC 0.5g

[0057] Magnesium stearate 0.02g

[0058] Microcrystalline cellulose 0.48g

[0059] Preparation:

[0060] 1) Prepare the levodropropizine inclusion compound according to the following method: use water as the solvent, react levodropropizine and β-cyclodextrin at a molar ratio of 1:1, the reaction temperature is 65°C, keep stirring , the reaction time was 30min, and the reaction solution was obtained; the obtained reaction solution was refrigerated for 24 hours, and the reaction precipitate was obtained by suction filtration, and the reaction precipitate was washed with absolute ethanol, and the clathrate was separated from the reaction precipitate, and the ...

Embodiment 2

[0063] Levodropropizine clathrate: the mol ratio of β-cyclodextrin is 1:1;

[0064] The prescription for dispersible tablets is (by weight):

[0065] Levodropropizine-β-cyclodextrin inclusion complex 16.12g

[0066] L-HPC 1.8g

[0067] Magnesium stearate 0.08g

[0068] The preparation method is the same as in Example 1.

Embodiment 3

[0070] Levodropropizine inclusion complex: β-cyclodextrin 1:1

[0071] The prescription for dispersible tablets is (by weight):

[0072] Levodropropizine-β-cyclodextrin inclusion compound 322.4g

[0073] L-HPC 36g

[0074] Magnesium stearate 1.6g

[0075] The preparation method is the same as in Example 1.

[0076] The products prepared in the above examples, after investigation, have significantly reduced bitterness.

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Abstract

The invention provides a levodropropizine clathrate dispersible tablet and a preparation method thereof. The invention, which processes levodropropizine as a clathrate firstly and then prepares a dispersible tablet from the levodropropizine clathrate, integrates inclusion and dispersion technologies to take the advantages of the two aspects. The levodropropizine is included by virtue of cyclodextrin and the dispersible tablet is prepared in coordination with accessories of special type and dosage, so as to solve a problem of bitterness and to take an effect of masking bitter taste; and the preparation effect of the dispersible tablet is significantly enhanced and a degradation effect is accelerated. The levodropropizine dispersible tablet prepared according to the formula can be completely released within a short time; the dispersible tablet is reasonable in formula, and is capable of masking the bitter taste, improving the mouthfeel of the levodropropizine dispersible tablet taken by patients and enhancing drug compliance; and the preparation process is simple and easy to implement, strong in operability, stable in process, and is capable of improving the bioavailability and curative effect of the medicine.

Description

technical field [0001] The application relates to the field of pharmacy, in particular to a levodropropizine inclusion compound dispersible tablet and a preparation method thereof. Background technique [0002] In China, due to factors such as dense population, large smoking population, and environmental pollution, the morbidity and mortality rates have remained high in recent years. Therefore, the development of drugs for respiratory diseases has also become an important part of drug research. [0003] Levodroproprazine is a peripheral antitussive drug, the English name is Levodroproplzine, white crystal, mp98-100 ℃, suitable for dry cough and persistent cough caused by acute upper respiratory tract infection and acute bronchitis, its antitussive effect and The same dose of centrally acting powerful antitussive drug codeine is comparable, but with fewer adverse reactions, almost no central sedative effect, no obvious side effects on the cardiovascular and respiratory syste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/69A61K31/495A61P11/14
Inventor 王慧娟赵珊周英林冰俸婷婷刘雄利
Owner GUIZHOU UNIV
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