Absorbable medical suture with good degradation resistance and compatibility and preparation method thereof

A compatible and degradation-resistant technology, applied in the field of medical sutures, it can solve the problems of slow degradation rate, supply, and easy cell adhesion, and achieve the effects of increasing smoothness, increasing compatibility, and improving cell affinity.

Active Publication Date: 2018-01-05
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] PGA fiber is very suitable for cell adhesion and reproduction, but due to its fast degradation rate, it cannot provide sufficient strength before tissue formation; compared with PGA fiber, the degradation rate of PLA fiber is slower, but PLA is hydrophobic, Cells cannot adhere and reproduce well on fibers. When using sutures made of this type of polymer, it is difficult to meet the two conditions of slow degradation rate and easy cell adhesion and reproduction.

Method used

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  • Absorbable medical suture with good degradation resistance and compatibility and preparation method thereof
  • Absorbable medical suture with good degradation resistance and compatibility and preparation method thereof
  • Absorbable medical suture with good degradation resistance and compatibility and preparation method thereof

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preparation example Construction

[0036] refer to figure 1 A method for preparing absorbable medical sutures with good degradation resistance and compatibility proposed by the present invention comprises the following steps:

[0037] S1. Preparation of the first wire core: mix polyglycolide, modified polylactic acid, glutaraldehyde, mannitol, and vanillin, extrude with a twin-screw extruder after heating up, cool, and pelletize to obtain the first mother core. Then heat up to melt the first masterbatch, defoam, and obtain material B through a spinneret; stretch material B in a water bath to obtain the first wire core;

[0038]S2. Preparation of the second wire core: mix polylactic acid, polyglycolide, modified polylactic acid, glutaraldehyde, mannitol, and vanillin, extrude with a twin-screw extruder after heating up, cool, and pelletize to obtain the second core. Second masterbatch; heating again to melt the second masterbatch, defoaming, and obtaining material C through a spinneret; stretching material C in...

Embodiment 1

[0042] An absorbable medical suture with good degradation resistance and compatibility, braided from at least one first fiber and / or second fiber, wherein the first fiber includes a first core and a second core coated on the outside of the first core. A coating, the second fiber includes a second core and a second coating coated on the outside of the second core;

[0043] The raw materials of the first core include by weight: 50 parts of polyglycolide, 10 parts of modified polylactic acid, 3 parts of glutaraldehyde, 4 parts of mannitol, and 3 parts of vanillin;

[0044] The raw materials of the second core include by weight: 60 parts of polylactic acid, 10 parts of polyglycolide, 20 parts of modified polylactic acid, 4 parts of glutaraldehyde, 5 parts of mannitol, and 4 parts of vanillin;

[0045] Wherein, the preparation method of the modified polylactic acid is as follows: add 12 parts of itaconic acid to 35 parts of benzoyl chloride in parts by weight, heat up to 150 ° C, k...

Embodiment 2

[0052] An absorbable medical suture with good degradation resistance and compatibility, braided from at least one first fiber and / or second fiber, wherein the first fiber includes a first core and a second core coated on the outside of the first core. A coating, the second fiber includes a second core and a second coating coated on the outside of the second core;

[0053] The raw materials of the first core include by weight: 70 parts of polyglycolide, 5 parts of modified polylactic acid, 5 parts of glutaraldehyde, 2 parts of mannitol, and 5 parts of vanillin;

[0054] The raw materials of the second core include by weight: 40 parts of polylactic acid, 20 parts of polyglycolide, 10 parts of modified polylactic acid, 6 parts of glutaraldehyde, 3 parts of mannitol, and 6 parts of vanillin;

[0055] Wherein, the preparation method of the modified polylactic acid is as follows: add 8 parts of itaconic acid to 45 parts of benzoyl chloride in parts by weight, heat up to 140 ° C, kee...

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Abstract

The invention discloses an absorbable medical suture thread with good degradation resistance and compatibility, which is obtained by braiding at least one first fiber and / or second fiber, wherein the first fiber includes a first core and is coated on the first thread The first coating on the outside of the core, the second fiber includes a second core and a second coating on the outside of the second core. The present invention also discloses a preparation method of the above-mentioned absorbable medical suture with good degradation resistance and compatibility, comprising the following steps: S1, preparing the first wire core; S2, preparing the second wire core; S3, coating weaving. The invention is resistant to degradation, has good mechanical properties, and has good compatibility with biological tissues, is beneficial to cell adhesion and propagation on the invention, is easy to operate, and is beneficial to industrialized production.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable medical suture with good degradation resistance and compatibility and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Synthetic polymer sutures include polyglycolide (PGA) sutures, polylactic acid (PLA) sutures, polydioxanone (PDS) sutures, and the like. Absorbable sutures can be degraded and absorbed in the body, which avoids the pain caused by the second surgery, and can choose sutures with different degradation times according to actual surgical needs. [0004] PGA fiber is very suitable for cell adhesion and reproduc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D02G3/44D02G3/36D02G3/04D01F6/92D01F8/14C08G63/08C08G63/78D06M15/507D06M13/188D06M101/32
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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