Meclofenoxate hydrochloride pharmaceutical composition capable of promoting brain energy metabolism

Abstract

The invention discloses a meclofenoxate hydrochloride pharmaceutical composition capable of promoting brain energy metabolism, and belongs to the technical field of medicines. The composition is prepared from meclofenoxate hydrochloride and sodium dihydrogen phosphate, wherein the meclofenoxate hydrochloride is crystal, and an X-ray powder diffraction pattern obtained by measuring through using a Cu-K alpha ray is shown as a figure 1. The novel crystal form of the meclofenoxate hydrochloride provided by the invention is different from the structure of an existing crystal from in the prior art. Through experimental verification, a meclofenoxate hydrochloride crystal compound provided by the invention is greatly improved in hygroscopicity and fluidity in comparison with those in the prior art, the water content and the impurity content are extremely low, the stability is good, and convenience is brought for the preparation of a preparation.

Description

Technical field [0001] The present invention is a pharmaceutical technology field involving a pinetic acid hydrochloride composition that promotes brain energy metabolism. Background technique [0002] The chemical name of methyl microscin hydrochloride is 2- (dihydramamin) ethyl acel oxide acetate hydrochloride hydrochloride.Functions, including causing awakening, exciting spirit, excitement of breathing, increasing neurode reflexes and increasing freedom activity. It can promote protein assimilation. In the body, it can be used as a raw material for synthetic choline and acetyl.Quality content, increase the amount of acetylcholine in the brain, have anti -hypoxia effects, promote the oxidation reaction of brain cells, promote brain energy metabolism, improve learning, memory, and cognitive functions, improve cerebral blood flow, promote the recovery of clinical symptoms signsEssence [0003] At present, namifafen hydrochloride preparations listed in China are mostly used for tr...

AI Technical Summary

Problems solved by technology

Although the existing technology has a certain effect in improving the stability of meclofenoxate hydrochloride in preparation, it needs to add more auxiliary materials and needs to cooperate with relatively complicated processes. Although it has a certain effect, the effect is limited, which limits the application of meclofenoxate hydrochloride. , because the easily hydrolyzed meclofenoxate hydrochloride is unstable in the raw material stage and requires extremely high storage conditions

Some prior art attempts to obtain meclofenoxate hydrochloride with higher stability by changing the crystal form, such as: Chinese application CN103214382B, the meclofenoxate hydrochloride compound and its drug combination provided by this application compared with the prior art, have Better storage stability and fluidity, the inventor found in the test that although the meclofenoxate hydrochloride obtained in the application has good stability under normal temperature and accelerated conditions, it has not been tested in other factors affecting drug quality. Poor stability in medium, especially still has high hygroscopicity, which makes meclofenoxate hydrochloride easy to attract moisture and hydrolyze

Chinese application CN103396328B, the inventor of this application unexpectedly obtained a crystal form of meclofenoxate hydrochloride compound in the course of long-term and extensive research. This compound has very low hygroscopicity, is not easy to hydrolyze by hygroscopicity, and has extremely high quality stability. However, its bioavailability is low and the incidence of side effects is high

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