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Applications of macrolide antibiotics and Erythromycin in preparation of anti-fatigue disease medicines

A macrolide, anti-fatigue technology, applied in the field of medicine

Inactive Publication Date: 2015-12-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the anti-fatigue effect of macrolide antibiotics represented by erythromycin

Method used

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  • Applications of macrolide antibiotics and Erythromycin in preparation of anti-fatigue disease medicines
  • Applications of macrolide antibiotics and Erythromycin in preparation of anti-fatigue disease medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 Anti-fatigue activity research

[0015] 1. Materials and methods

[0016] (1) Reagents

[0017]

[0018] (2) Main solution configuration

[0019] 1. 0.8% sodium hydroxymethylcellulose solution

[0020] Reagent name and dosage

[0021] Sodium hydroxymethylcellulose 0.8g

[0022] Single distilled water 1000ml

[0023] 2. Erythromycin suspension (orally administered to mice)

[0024] Reagent name and dosage

[0025] Erythromycin 0.01g

[0026] CMC-Na solution 0.8ml

[0027] 3. Clarithromycin suspension (orally administered to mice)

[0028] Reagent name and dosage

[0029] Clarithromycin 0.01g

[0030] CMC-Na solution 0.8ml

[0031] 4. Azithromycin suspension (orally administered to mice)

[0032] Reagent name and dosage

[0033] Azithromycin 0.01g

[0034] CMC-Na solution 0.8ml

[0035] (3) Experimental animals

[0036] Animal breeding: C57 mice, male, 18-22 g, were obtained from the Experimental Animal Center of Second Military Medical Un...

Embodiment 2

[0057] Example 2 Effects on Biochemical Indexes of Mice After Exercise

[0058] 1. Materials and methods

[0059] 1. Reagents and Experimental Animals

[0060] As in Example 1, 120 experimental mice were randomly divided into 2 batches, and the serum urea nitrogen, blood lactic acid, hemoglobin, lactate dehydrogenase, and liver glycogen assays were respectively carried out. Each batch of animals was further divided into 6 groups, which were erythromycin low-dose group, erythromycin middle-dose group, erythromycin high-dose group, clarithromycin group, azithromycin group and control group, with 10 animals in each group. According to the dosage of erythromycin 5mg / kg, erythromycin 15mg / kg, erythromycin 60mg / kg, clarithromycin 15mg / kg and azithromycin 15mg / kg, the doses of CMC-Na solution. The mice were kept under normal light, drinking water, and kept at 25°C. Oral gavage once a day, the amount of gavage is 1% of the weight of the mice, and the indicators are measured after ...

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Abstract

The invention relates to applications of macrolide antibiotics, especially Erythromycin, in preparation of anti-fatigue disease medicines. The anti-fatigue function of macrolide antibiotics, especially Erythromycin is discovered firstly, animal test results show that macrolide antibiotics can prolong swimming time of mice bearing load greatly, lower the serum urea ammonia level after strenuous exercise, inhibit rise of blood lactic acid, keep or increase the content of ferrohemoglobin, raise lactate dehydrogenase activity, raise liver starch reserve, reduce liver starch consumption during exercise, and have functions of alleviating fatigue and increasing exercise endurance greatly.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of macrolide antibiotics and erythromycin in the preparation of fatigue-resistant medicines. Background technique [0002] Macrolides are a class of basic lipophilic antibiotics with twelve- to twenty-membered rings. Among them, erythromycin is its classic representative drug. Clinical and experimental studies have found that erythromycin is the most effective and safe drug for the treatment of Legionnaires' disease. In addition, it is also effective in some other bacterial infections, such as Helicobacter pylori. More and more reports have recently found that macrolide compounds are not only an antibiotic, but also have other biological activities: research has found that fourteen-membered ring derivatives (erythromycin, roxithromycin, carat erythromycin) can stimulate the proliferation of monocyte / macrophage stem cells; Anssers found that erythromycin can ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P39/00
Inventor 苏定冯刘霞雷虹孙旸
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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