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Sustained-release bupleurum tenue tablet and method for preparing same

A slow-release tablet and Xiao Bupleurum technology, which is applied in antiviral agents, medical formulas, medical preparations of non-active ingredients, etc., can solve problems such as frequent taking of medicines, large doses, and destruction of the active ingredient saikosaponin a , to achieve the effect of taking less times, taking less doses, and taking less

Active Publication Date: 2015-12-02
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problems that the existing Xiaochaihu tablets and Xiaochaihu granules have large doses, many times of taking medicine, and the traditional water decoction extraction process is easy to destroy the active ingredients saikosaponin a and d, and provide a Xiao Bupleurum slow Release tablet and preparation method thereof

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  • Sustained-release bupleurum tenue tablet and method for preparing same

Examples

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Embodiment 1

[0022] A kind of Xiaobupleuri sustained-release tablet in the present embodiment, it is made of the following raw materials by weight: 55 parts of total extracts of Xiaobupleurum, 20 parts of hydroxypropyl methylcellulose K15M, 2 parts of microcrystalline cellulose and 0.5 parts of magnesium stearate;

[0023] The total extract of Bupleurum baicalensis is made of the following raw materials in parts by weight: 680 parts of Bupleurum, 280 parts of Codonopsis, 280 parts of Jujube, 70 parts of Scutellaria baicalensis extract, 70 parts of licorice liquid extract, 280 parts of ginger and 280 parts of Jiang Pinellia share.

[0024] A method for preparing the Xiaobupleurum sustained-release tablet described in the present embodiment, comprising the following steps:

[0025] 1) Prepare the total extract of Bupleuri

[0026] a. First use 60% ethanol to extract 680 parts by weight of Bupleurum radix, 280 parts by weight of Codonopsis pilosula and 280 parts by weight of Chinese jujube ...

Embodiment 2

[0032] A kind of Xiaobupleuri sustained-release tablet in the present embodiment, it is made of the raw material of following parts by weight: 65 parts of total extracts of Xiaobupleurum, 40 parts of hydroxypropyl methylcellulose K15M, 5 parts of microcrystalline cellulose and 1.5 parts of magnesium stearate;

[0033] The total extract of Bupleurum baicalensis is made of the following raw materials in parts by weight: 680 parts of Bupleurum, 280 parts of Codonopsis, 280 parts of Jujube, 70 parts of Scutellaria baicalensis extract, 70 parts of licorice liquid extract, 280 parts of ginger and 280 parts of Jiang Pinellia share.

[0034] A method for preparing the Xiaobupleurum sustained-release tablet described in the present embodiment, comprising the following steps:

[0035] 1) Prepare the total extract of Bupleuri

[0036] a, at first use the ethanol that concentration is 70% to adopt reflux method to extract 3 times for 680 parts by weight of Radix Bupleurum, 280 parts by ...

Embodiment 3

[0042] A kind of Xiaobupleuri sustained-release tablet in the present embodiment, it is made of the following raw materials by weight: 60 parts of total extracts of Xiaobupleurum, 30 parts of hydroxypropyl methylcellulose K15M, 3 parts of microcrystalline cellulose and 1 part magnesium stearate;

[0043] The total extract of Bupleurum baicalensis is made of the following raw materials in parts by weight: 680 parts of Bupleurum, 280 parts of Codonopsis, 280 parts of Jujube, 70 parts of Scutellaria baicalensis extract, 70 parts of licorice liquid extract, 280 parts of ginger and 280 parts of Jiang Pinellia share.

[0044] A method for preparing the Xiaobupleurum sustained-release tablet described in the present embodiment, comprising the following steps:

[0045] 1) Prepare the total extract of Bupleuri

[0046] a. First use 65% ethanol to extract 680 parts by weight of Bupleurum radix, 280 parts by weight of Codonopsis pilosula and 280 parts by weight of jujube by refluxing t...

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Abstract

The invention belongs to the technical field of medicine preparations and methods for preparing the same, and particularly relates to a sustained-release bupleurum tenue tablet and a method for preparing the same. By the aid of the sustained-release bupleurum tenue tablet and the method, technical problems of high administration dose and medication frequencies of existing bupleurum tenue tablets and bupleurum tenue granules and easiness in destroying saikoside a and d of effective components due to the traditional water decoction and extraction processes mainly can be solved. The sustained-release bupleurum tenue tablet and the method have the advantages that effective components are extracted by the aid of ethyl alcohol reflux processes, alcohol extraction reflux processes for extracting saikoside a are superior to water extraction reflux processes by 2.4-4.7 times, effective components of codonopsis pilosula and jujube can be purified by means of ethyl alcohol reflux extraction, and impurities such as starch and polysaccharides can be removed; the sustained-release bupleurum tenue tablet is high in effective component content, and the scutellaria baicalensis content of each tablet is not lower than 24.0mg as measured by the baicalin and is not lower than 0.96mg as measured by baicalein; the sustained-release bupleurum tenue tablet is low in administration frequencies and administration dose, and only one sustained-release bupleurum tenue tablet needs to be taken in every 12 hours; the sustained-release bupleurum tenue tablet is low in administration dose and medication frequency, and the effective components can be prevented from being destroyed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and preparation methods thereof, and in particular relates to a small bupleurum sustained-release tablet and a preparation method thereof. Background technique [0002] Cold is divided into common cold and influenza. The common cold is a common respiratory disease caused by a variety of viruses; influenza, an acute respiratory infectious disease caused by influenza virus, is one of the viral infectious diseases that seriously endanger human health. Xiao Chaihu Decoction comes from Zhang Zhongjing's "Treatise on Febrile Diseases". It is composed of Bupleurum, Scutellaria, Ginseng, Pinellia, Zhigancao, Ginger, and Jujube. It is used to treat typhoid and shaoyang syndrome. The role of external liver disease, evil offender Shaoyang syndrome. Bupleurum bupleurum has a significant antiviral effect, not only can inhibit the reverse transcriptase and DNA-P activity of the virus, but ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K47/38A61K9/22A61P11/00A61P31/12A61P31/16
Inventor 杜艳薛吉利张丽萍梁桂贤丁红
Owner SHANXI MEDICAL UNIV