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A kind of degradable starch-based hemostatic material and its preparation method and application

A hemostatic material and a technology of degrading starch, applied in the field of degradable starch-based hemostatic material and its preparation, can solve the problems of limited activation of the coagulation system, unsatisfactory hemostatic effect, toxicity, etc., to enrich the coagulation surface, promote platelet adhesion, and strong water absorption sexual effect

Inactive Publication Date: 2018-02-16
CHENGDU RENTIAN MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. It mainly relies on absorbing water in the blood to stop bleeding, and has limited activation of the coagulation system;
[0008] 2. The retrograde property is poor, which can easily cause the shedding of blood scab and destroy the new tissue, which directly affects the hemostatic effect of the material;
[0009] 3. The cross-linking process adopted by some starch-based hemostatic materials is complicated, the cross-linking residue is large, and it has certain toxicity;
[0010] 4. The price of some imported materials is high, the packaging volume is small, and the cost-effectiveness of application is not ideal;
[0011] 5. Hemostasis limited to small trauma and body surface (such as skin) in the body, and the hemostatic effect on deep solid organs and active parts is not ideal;
[0012] 6. Lack of basis for drug loading and simultaneous application with hemostatic materials with other hemostatic mechanisms

Method used

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  • A kind of degradable starch-based hemostatic material and its preparation method and application
  • A kind of degradable starch-based hemostatic material and its preparation method and application
  • A kind of degradable starch-based hemostatic material and its preparation method and application

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Effect test

Embodiment 1

[0044] Embodiment 1: a kind of preparation method of degradable starch-based hemostatic material, it comprises the following steps:

[0045] S1. Raw material processing: wash the mung bean starch with water;

[0046] S2. Ultrasonic treatment: Ultrasonic treatment is performed on the cleaned mung bean starch for 6 hours, the ultrasonic frequency is 15KHz, and the power is 1800W;

[0047] S3. Cross-linking: Add ultrapure water to mung bean starch, heat up to 30°C, add sodium chloride with a concentration of 1% (w / w) and sodium trimetaphosphate solution with a concentration of 2% (w / w), and keep warm for 10 minutes , adjust the pH value to 11 with 1.0 mol / L sodium hydroxide, stir and react for 2 hours, neutralize with 1.0 mol / L hydrochloric acid until the pH value of the solution is 6, obtain cross-linked starch and wash it;

[0048] S4. Enzyme pore making: mix cross-linked starch, calcium chloride, and ɑ-amylase for 2 hours, and the weight ratio of cross-linked starch, calcium ...

Embodiment 2

[0049] Embodiment 2: a kind of preparation method of degradable starch-based hemostatic material, it comprises the following steps:

[0050] S1. Raw material processing: washing the sweet potato starch with water;

[0051] S2. Cross-linking: Add ultrapure water to sweet potato starch, heat up to 70°C, add sodium chloride with a concentration of 5% (w / w) and sodium trimetaphosphate solution with a concentration of 8% (w / w), and keep warm for 60 minutes , adjust the pH value to 11 with 1.0 mol / L sodium hydroxide, stir and react for 48 hours, neutralize with 1.0 mol / L hydrochloric acid until the pH value of the solution is 7, obtain cross-linked starch and wash it;

[0052] S3. Ultrasonic treatment: Ultrasonic treatment is performed on the cross-linked starch for 8 hours, the ultrasonic frequency is 25KHz, and the power is 2500W;

[0053] S4. Enzyme pore making: Mix and react ultrasonically treated cross-linked starch, calcium chloride, and ɑ-amylase for 24 hours, and the weight...

Embodiment 3

[0054] Embodiment 3: a kind of preparation method of degradable starch-based hemostatic material, it comprises the following steps:

[0055] S1. Raw material processing: washing the potato starch with water;

[0056] S2. Ultrasonic treatment: Ultrasonic treatment is performed on the cleaned potato starch for 7 hours, the ultrasonic frequency is 18KHz, and the power is 2000W;

[0057] S3. Cross-linking: Add ultrapure water to potato starch, heat up to 40°C, add sodium chloride with a concentration of 2% (w / w) and sodium trimetaphosphate solution with a concentration of 4% (w / w), and keep warm for 25 minutes , adjust the pH value to 11 with 1.0 mol / L sodium hydroxide, stir and react for 20 hours, neutralize with 1.0 mol / L hydrochloric acid until the pH value of the solution is 6.5, obtain cross-linked starch and wash it;

[0058] S4. Enzyme pore creation: mix cross-linked starch, calcium chloride, and ɑ-amylase for 10 hours, and the weight ratio of cross-linked starch, calcium ...

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Abstract

The invention discloses a degradable starch-based hemostatic material, a preparation method therefor and applications. The preparation method comprises steps: firstly, raw materials processing is carried out, namely, starch is cleaned in water; secondly, crosslinking is carried out, namely, ultrapure water is added in starch, the temperature is risen to 30-70 DEG C, sodium chloride and a sodium trimetaphosphate solution are added, heat insulation is carried out for 10-60min, a reaction with stirring is carried out for 2-48h, the solution pH is adjusted, and crosslinking starch is obtained; thirdly, enzyme pore forming is carried out, namely, the crosslinking starch, calcium chloride and alpha-amylase are mixed and reacted for 2-24 h, the reaction temperature is 50-75 DEG C, and the degradable starch-based hemostatic material is obtained after cleaning. The degradable starch-based hemostatic material can be used for preparing a hemostatic material of body surfaces and tissues in bodies, and preparing a bleeding control material for excessive bleeding of parenchymal viscera in the bodies or movable parts or parts difficult for haemostasis. The degradable starch-based hemostatic material is advantaged by good biological compatibility, degradation in bodies, low cost, simple preparation, convenient production, no toxins and environmental protection.

Description

technical field [0001] The invention belongs to the field of tissue damage repairing medical devices, in particular to a degradable starch-based hemostatic material and its preparation method and application. Background technique [0002] Blood has the functions of nourishing and moistening various tissues and organs of the whole body, and is one of the basic substances that constitute the human body and maintain human life activities. Traumatic hemorrhage is a common occurrence in human life, and acute massive hemorrhage and deep hemorrhage of substantial organs caused by war, traffic accidents, natural disasters, etc. are the main causes of death, disability and teratogenicity after human injury. When the traumatic blood loss reaches more than 20% of the total blood volume, obvious shock symptoms appear; when it reaches 40% of the total blood volume, there is life-threatening. Effective hemostasis is a necessary guarantee for the safety of patients, and it is also an effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/718A61L15/28A61L15/44A61K47/36A61P7/04C08J3/24C08L3/02C08K3/16C08K3/32C12P19/14C12P19/04
Inventor 袁暾杜彦军
Owner CHENGDU RENTIAN MEDICAL EQUIP CO LTD