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An antibody-coupled mesoporous silica/mifepristone nano-preparation

A technology of mesoporous silica and mifepristone, which is applied in the direction of antibodies, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., to achieve inhibitory activity, prevent CTCs from adhering to the intima of blood vessels, The effect of preventing and treating tumor metastasis

Active Publication Date: 2018-04-13
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Retrieval of relevant literature and patents at home and abroad shows that so far, there is no drug that can specifically target CTCs and regulate the activity of CTCs to prevent and inhibit micrometastasis

Method used

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  • An antibody-coupled mesoporous silica/mifepristone nano-preparation
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  • An antibody-coupled mesoporous silica/mifepristone nano-preparation

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Embodiment 1

[0030](1) Measure 20 mL of ultrapure water into a 50 mL round bottom flask, add 2.0 g of cetyltrimethylammonium chloride (CTAC), stir at room temperature until completely dissolved, add 0.02 mg of triethanolamine (TEA), Heat, condense and stir in an oil bath at 95°C for 1 h. Then 1.5 mL of tetraethylsilane (TEOS) was added dropwise, and continued to heat, condense and stir in an oil bath at 95 °C for 1 h. The sample was cooled to room temperature, and washed 3-4 times by high-speed centrifugation with absolute ethanol to remove residual reaction reagents. Then the samples were collected in 20 mL of washing solvent (0.2 g sodium chloride dissolved in 20 mL of methanol), stirred at room temperature for 3 h, and washed by high-speed methanol centrifugation. Repeat the above washing step 3-4 times to remove the templating agent CTAC. Freeze-dry to obtain white MSN solid powder.

[0031] (2) Measure 2.5 mL of 3-aminopropyltriethoxysilane (APTES) and 75 mg of succinic anhydride i...

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Abstract

The invention discloses an antibody-coupled mesoporous silicon dioxide / mifepristone nano preparation, a preparation method and an application thereof. The formulation comprises mesoporous silica nanoparticles (MSN), mifepristone (MIF) and epithelial cell adhesion molecule antibody (anti-EpCAM, aE), said MSN loaded with MIF, said aE covalently modified on MSN s surface. The antibody-coupled mesoporous silica / mifepristone nano-preparation of the present invention can not only identify and suppress the activity of circulating tumor cells (CTCs), but also inhibit the adhesion between CTCs and the vascular intima, interfere with Tumor metastasis process, significantly curb tumor metastasis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an antibody-coupled mesoporous silicon dioxide / mifepristone nano-preparation and a preparation method and application thereof. Background technique [0002] Tumor metastasis is one of the main reasons for tumor refractory and recurrence. The primary tumor can be effectively controlled or even cured by surgical resection, radiotherapy or other local treatments, but it is often difficult to control the further development of the disease with the above-mentioned methods for the spread of the tumor. Tumor metastasis is composed of a series of cascading steps: (1) primary tumor cells invade the adjacent extracellular matrix and interstitial cell layer; (2) invade the vessel wall; (3) penetrate the vasculature; (4) ) Adhesion and implantation in distal tissues; (5) Leaving the circulation to the surrounding interstitium; (6) Adapting to the new environment to form micr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/567A61K39/395A61K47/69A61K47/68A61P35/04
Inventor 高瑜贾力顾颂恩
Owner FUZHOU UNIV
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