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Industrialization production method and application of acanthopanax senticosus polysaccharide

A technology of Acanthopanax polysaccharides and production methods, applied in the production of bulk chemicals, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of avoiding waste, high yield, and significant curative effect

Active Publication Date: 2015-12-09
JILIN TEACHERS INST OF ENG & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acanthopanax polysaccharide is one of the functional factors with the highest content and the most extensive effect in the active ingredients of Acanthopanax. There is no report about the therapeutic effect of Acanthopanax senticosus polysaccharide on tuberculosis

Method used

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  • Industrialization production method and application of acanthopanax senticosus polysaccharide
  • Industrialization production method and application of acanthopanax senticosus polysaccharide
  • Industrialization production method and application of acanthopanax senticosus polysaccharide

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The industrialized production method of Acanthopanax quincis polysaccharide adopts the following specific techniques.

[0032] (1) Pretreatment: Select the roots and rhizomes of Acanthopanax senticosus, with a water content of 8wt%, and crush them until the pass rate of 20-mesh sieve is more than 90%, and the pass rate of 80-mesh sieve is less than 10%, so as to obtain Acanthopanax senticosus powder, which is set aside .

[0033] (2) Impurity removal: the Acanthopanax senticosus powder is extracted by supercritical to remove small molecular impurities to obtain the Acanthopanax senticosus extract;

[0034] The supercritical extraction condition is CO 2 The flow rate is 1200L / h, the extraction pressure is 28MPa, the extraction temperature is 43°C, the extraction time is 0.5h, the separation pressure is 7MPa, the separation temperature is 22°C, and the separation time is 0.5h.

[0035] (3) Extraction: soak the Acanthopanax acanthopanax extract in equal quality water at ...

Embodiment 2

[0042] The industrialized production method of Acanthopanax quincis polysaccharide adopts the following specific techniques.

[0043] (1) Pretreatment: Select the roots and rhizomes of Acanthopanax senticosus, with a water content of 16wt%, and crush them until the pass rate of 20-mesh sieve is more than 90%, and the pass rate of 80-mesh sieve is less than 10%, so as to obtain Acanthopanax senticosus powder, which is set aside .

[0044] (2) Impurity removal: the Acanthopanax senticosus powder is extracted by supercritical to remove small molecular impurities to obtain the Acanthopanax senticosus extract;

[0045] The supercritical extraction condition is CO 2 The flow rate is 1400L / h, the extraction pressure is 20MPa, the extraction temperature is 65°C, the extraction time is 3h, the separation pressure is 11MPa, the separation temperature is 37°C, and the separation time is 3h.

[0046] (3) Extraction: The Acanthopanax acanthopanax extract is soaked in equal quality water ...

Embodiment 3

[0053] The industrialized production method of Acanthopanax quincis polysaccharide adopts the following specific techniques.

[0054] (1) Pretreatment: Select the roots and rhizomes of Acanthopanax senticosus, with a water content of 12wt%, and crush them until the pass rate of 20-mesh sieve is more than 90%, and the pass rate of 80-mesh sieve is less than 10%, so as to obtain Acanthopanax senticosus powder, which is set aside .

[0055] (2) Impurity removal: the Acanthopanax senticosus powder is extracted by supercritical to remove small molecular impurities to obtain the Acanthopanax senticosus extract;

[0056] The supercritical extraction condition is CO 2 The flow rate is 1250L / h, the extraction pressure is 22MPa, the extraction temperature is 47°C, the extraction time is 2h, the separation pressure is 8MPa, the separation temperature is 28°C, and the separation time is 1.5h.

[0057] (3) Extraction: soak the Acanthopanax acanthopanax extract with equal quality water at...

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Abstract

The invention relates to an industrialization production method and application of acanthopanax senticosus polysaccharides. The method comprises the following specific steps: selecting the root and rhizome parts of acanthopanax senticosus, smashing to obtain an acanthopanax senticosus powder material, and performing supercritical extraction to obtain acanthopanax senticosus extract; adding water to perform continuous counter-current extraction to obtain extract liquor; performing nonpolar or weak-polarity macroporous resin adsorption, low-degree alcohol elution, washing liquor filtering and concentration and drying to obtain the acanthopanax senticosus polysaccharides, and performing concentration and drying on low-degree alcohol eluant to obtain eleutheroside E. Supercritical carbon dioxide is used for edulcorating the acanthopanax senticosus material, and pressure in a subsequent resin adsorption process is reduced; the eleutheroside E is extracted when the acanthopanax senticosus polysaccharides are extracted; materials are comprehensively utilized; the total extraction ratio of the eleutheroside E reaches over 90 percent; and the yield of polysaccharide content is over 95 percent; the obtained acanthopanax senticosus polysaccharides have a remarkable curative effect in the aspect of curing tuberculosis.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to an industrial production method and application of Acanthopanax polysaccharides. Background technique [0002] At present, the principle of directly supervised chemotherapy (DOTS) is always implemented and followed for clinically positive patients with Mycobacterium tuberculosis. The initial treatment regimen with ambutol as the main drug; the retreatment regimen based on prothionamide, kanamycin, etc.; the multidrug-resistant tuberculosis treatment based on ciprofloxacin, ofloxacin, etc. Program. Most of the above-mentioned anti-tuberculosis drugs commonly used in clinical practice can cause abnormal liver function in the body, and combined with long-term drug use, it will greatly increase the chance of liver damage. Once due to abnormal liver function, the anti-tuberculosis drug is forced to reduce the dose or even stop the drug or change the drug, the My...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P31/06
CPCY02P20/54
Inventor 潘景芝孟庆龙刘雅静陈丽任跃英崔文玉张健
Owner JILIN TEACHERS INST OF ENG & TECH
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