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Application of micro-nanocapsule encapsulation technology in the preparation of component traditional Chinese medicine Linggui Yizhi Tablets

A micro-nanocapsule technology, applied in the field of Linggui Yizhi tablet preparations, can solve the problems of reducing the drug effect and poor stability of active ingredients, and achieve the effect of preventing drug oxidation

Active Publication Date: 2019-06-18
SHANGHAI ZHANGJIANG ENG & RES CENT FOR TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the stability of the active ingredient of Guiling Yizhi Tablets is not good, which reduces the drug effect

Method used

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  • Application of micro-nanocapsule encapsulation technology in the preparation of component traditional Chinese medicine Linggui Yizhi Tablets
  • Application of micro-nanocapsule encapsulation technology in the preparation of component traditional Chinese medicine Linggui Yizhi Tablets
  • Application of micro-nanocapsule encapsulation technology in the preparation of component traditional Chinese medicine Linggui Yizhi Tablets

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Components: Poria cocos 1667g, Atractylodes macrocephala (fried) 833g, angelica 500g, glycerin 30g, poloxamer 90g, glucose 5g, mannitol 5g, povidone (PVP) 10g, sodium carboxymethyl starch 20g, magnesium stearate 2g, appropriate amount of lactose.

[0043] refer to figure 1 , the preparation method is as follows:

[0044] Get Poria cocos 1667g, Atractylodes macrocephala (fried) 833g, angelica 500g pulverize and cross 10 mesh sieves, CO 2 Supercritical extraction to obtain an oily extract for later use. The dregs were extracted with water for 0.5 hr, filtered, the extract was concentrated under reduced pressure to an appropriate amount, dried in vacuum, crushed and passed through a 60-mesh sieve to obtain a fine powder.

[0045] Take 10 times the amount of supercritical extract in water, add 30g of glycerin and 90g of poloxamer to homogenize at high speed, add dropwise supercritical extraction oil and continue homogenizing to form a uniformly dispersed emulsion, then u...

Embodiment 2

[0048] Components: Poria cocos 1667g, Atractylodes macrocephala (stir-fried) 833g, angelica 500g, 95% ethanol 250ml, PBCA 25ml, dextran 100g, Tween-2050g, water 5000ml.

[0049] refer to figure 1 , the preparation method is as follows:

[0050] Get Poria cocos 1667g, Atractylodes macrocephala (fried) 833g, angelica 500g pulverize and cross 10 mesh sieves, CO 2 Supercritical extraction to obtain an oily extract for later use. The dregs were extracted with water for 0.5 hr, filtered, the extract was concentrated under reduced pressure to an appropriate amount, dried in vacuum, crushed and passed through a 60-mesh sieve to obtain a fine powder.

[0051] Add PBCA to ethanol to disperse evenly to obtain a white emulsion; add supercritical extraction oil to disperse evenly, place in the refrigerator to cool, and wait until the temperature drops below 20°C to obtain an oil phase. Add Tween 20 and dextran into water to dissolve, then place in the refrigerator to cool, and wait unti...

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Abstract

The invention provides application of a micro / nano capsule packaging technology to preparation of component traditional Chinese medicine poris cocos and angelica sinensis intelligence improving tablets and the prepared poris cocos and angelica sinensis intelligence improving tablets. The application includes the steps that poris cocos, bighead atractylodes rhizome and angelica sinensis are extracted supercritically to obtain supercritical extract and decoction dregs; the supercritical extract is prepared into micro / nano capsules; the decoction dregs are extracted with water to obtain powder; the micro / nano capsules are mixed with the powder to prepare the medicine preparation. The micro / nano capsule preparation technology is applied to wrapping of supercritical extract oil, and films of the micro / nano capsules prepared through the method can prevent the medicine from being oxidized, hydrolyzed and volatilized, and play a role in isolating weak polar supercritical extract from water extracted polar components.

Description

technical field [0001] The invention relates to a traditional Chinese medicine pharmaceutical technology, in particular to a method for preparing a traditional Chinese medicine Linggui Yizhi Tablet preparation with good stability, and the Linggui Yizhi Tablet preparation prepared by the method. Background technique [0002] Guiling Yizhi Tablets (Guiling Tablets) is composed of three herbs, Poria, Angelica, and Atractylodes Rhizoma, and is simplified from the classic prescription Danggui Shaoyao Powder. Studies have shown that Guiling Yizhi Tablets have good anti-cerebral ischemia, improving brain microbiome The function of circulation can significantly improve the memory dysfunction of mice and rats caused by different mechanisms, and can be used for the prevention and treatment of cerebral ischemic diseases, such as vascular dementia and ischemic stroke. [0003] It has been reported in the literature that atractylone, atractyloid I, atractyloid II, and atractyloderm III i...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/51A61K36/284A61P9/10A61P25/28
Inventor 张艳红姚譞樊敏伟
Owner SHANGHAI ZHANGJIANG ENG & RES CENT FOR TRADITIONAL CHINESE MEDICINE
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