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Antibacterial treatment method for titanium metal surface

A treatment method, titanium metal technology, applied in the field of medical titanium metal surface treatment, can solve problems such as difficult to meet clinical requirements, dysfunction, antibiotic resistance, etc., achieve excellent antibacterial performance and biocompatibility, and not easy to drug resistance , Excellent antibacterial and biocompatibility effects

Active Publication Date: 2018-06-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the implants added with these antibacterial agents have strong antibacterial properties, there are still some problems in clinical application.
For example, the implants with silver ions are more toxic to the cells, especially the silver ions can penetrate into the cells and damage the mitochondria in the cells, making them dysfunctional. It is not clear whether it will affect the variation of cell metabolism
Implants with antibiotics are easy to make bacteria resistant to antibiotics, and the emergence of drug-resistant superbugs has become a major clinical problem.
[0003] Therefore, although the above antibacterial methods play an important role in current clinical practice, it is still difficult to meet clinical requirements.

Method used

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  • Antibacterial treatment method for titanium metal surface
  • Antibacterial treatment method for titanium metal surface
  • Antibacterial treatment method for titanium metal surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:

[0035] (1) Treat the surface of medical titanium metal with 5% hydrofluoric acid for 3 minutes; (2) Dissolve the silane coupling agent with an alkynyl group in a mixed solution of water and ethanol, wherein the volume ratio of water and ethanol is 1 : 19, utilize acetic acid to adjust the pH of the solution to 3; (3) drip 10 microliters of the silane coupling agent solution in step (2) to the titanium metal surface, and carry out curing treatment, and the curing time is 4 hours; (4) configuration Click reaction solution, which consists of: 100 μM anhydrous copper sulfate, 2.5 mM sodium ascorbate, 100 μM antibacterial peptide KRWWKWWRR; (5) 1 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm 3 hours; (6) Fully rinse the surface of the sample wi...

Embodiment 2

[0042] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:

[0043] (1) Treat the surface of medical titanium metal with 10% hydrofluoric acid for 1 minute; (2) Use a mixed solution of water and ethanol as a solvent to dissolve the silane coupling agent with an alkynyl group, wherein the volume ratio of water and ethanol is 1 : 8, utilize acetic acid to adjust the pH of the solution to 5; (3) drip 100 microliters of the silane coupling agent solution in step (2) to the titanium metal surface, and perform curing treatment, and the curing time is 1 hour; (4) configuration Click reaction solution, which consists of: 1000 μM anhydrous copper sulfate, 10 mM sodium ascorbate, 1000 μM antibacterial polypeptide KRWWKWWRRC; (5) 0.1 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm 2 hours; (6) Fully rinse the su...

Embodiment 3

[0050] The antibacterial treatment method of the titanium metal surface of the present embodiment, the steps are as follows:

[0051] (1) Treat the surface of medical titanium metal with 8% hydrofluoric acid for 3 minutes; (2) Dissolve the silane coupling agent with an alkynyl group in a mixed solution of water and ethanol, wherein the volume ratio of water and ethanol is 1 : 15, utilize acetic acid to adjust the pH of the solution to 4.5; (3) drip 80 microliters of the silane coupling agent solution in step (2) to the titanium metal surface, and carry out curing treatment, and the curing time is 2 hours; (4) configuration Click reaction solution, which consists of: 1000 μM anhydrous copper sulfate, 8 mM sodium ascorbate, 800 μM antibacterial polypeptide KRWWKWWRR; (5) 3 mL of the above click reaction solution is added to the surface of titanium metal, and reacted in a nitrogen environment with an oxygen content lower than 1 ppm for 3 (6) Fully rinse the surface of the sample ...

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Abstract

The invention discloses an antibacterial treatment method for the surface of titanium metal, which comprises the following steps: (1) treating the surface of medical titanium metal with hydrofluoric acid; (2) using a mixed solution of water and ethanol as a solvent to dissolve the (3) adding the silane coupling agent solution dropwise to the titanium metal surface for curing treatment; (4) adding the click reaction solution containing the antibacterial polypeptide dropwise to the step ( 3) reacting the prepared titanium metal surface; (5) fully cleaning the sample in step (4) with deionized water and ethanol to obtain a titanium-based hard tissue implant material with an antibacterial surface. The antibacterial treatment method for the titanium metal surface of the invention significantly improves the antibacterial performance of the medical titanium metal surface, has excellent biocompatibility, and can be widely used as clinical medical materials.

Description

technical field [0001] The invention relates to a treatment method for the surface of medical titanium metal, in particular to an antibacterial treatment method for the surface of titanium metal. Background technique [0002] At present, the methods commonly used to improve the antibacterial properties of titanium metal surfaces are to coat the surface with ionic antibacterial agent coatings (such as silver sulfadiazine, etc.) and antibiotic antibacterial agent coatings (such as tetracycline and vancomycin, etc.). Although the implants added with these antibacterial agents have strong antibacterial properties, there are still certain problems in clinical application. For example, the implants with silver ions are more toxic to the cells, especially silver ions can penetrate into the cells and damage the mitochondria in the cells, making them dysfunctional. It is not yet clear whether it will affect the variation of cell metabolism. The addition of antibiotics to implants ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/54
Inventor 任力王琳王迎军陈军建刘卅施雪涛杨军忠
Owner SOUTH CHINA UNIV OF TECH