Antimicrobial peptide XYZ-1 and application thereof

Abstract

The invention discloses an antimicrobial peptide XYZ-1. The antimicrobial peptide XYZ-1 is a straight-chain peptide, and contains 19 amino acid residues, the molecular weight is 2288.81Da, the isoelectric point is 10.83, and the amino acid sequence of the antimicrobial peptide XYZ-1 is arginine-glycine-glycine-arginine-leucine-cysteine-tyrosine-cysteine-arginine-arginine-arginine-proline-cysteine-valine-cysteine-valine-glycine-arginine-lysine (SEQ ID NO.1). The antimicrobial peptide XYZ-1 disclosed by the invention does not produce hemolysis, the antimicrobial spectrum is wide, the antimicrobial peptide XYZ-1 has a highly effective antimicrobial effect on gram-positive bacteria, gram-negative bacteria and fungi, and therefore can be applied perfectly in the preparation of drugs for treating gram-positive bacterium, gram-negative bacterium or / and fungus disease infections, the clinical application effect of the antimicrobial peptide XYZ-1 is better, and moreover, the antimicrobial peptide XYZ-1 can also be used in the preparation of feed additives or food additives.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to an antibacterial peptide XYZ-1 and its application. Background technique [0002] Antimicrobial peptides (AMPs) are a class of defensive small peptides produced by biological organisms when resisting pathogenic microorganisms, and are an important part of the biological immune defense system. In addition to broad-spectrum antibacterial (Gram-negative bacteria and Gram-positive bacteria) activity, antimicrobial peptides also have a strong ability to kill fungi, viruses and parasites. Compared with traditional antibiotics, antimicrobial peptides have the advantages of small molecular weight, good thermal stability, good water solubility, broad antibacterial spectrum, are not easy to induce bacterial resistance, and do not produce drug allergic reactions. They are currently the most internationally recognized antibiotics. good substitute. [0003] However, natur...

AI Technical Summary

Problems solved by technology

At present, there is no unified understanding of the mechanism of action of antimicrobial peptides; however, most theories believe that its mechanism of action is related to its cationic and hydrophobic properties

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