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Preparation method of vitamin E soft capsules with good stability

A vitamin and soft capsule technology, applied in the field of preparation of vitamin E soft capsules, can solve the problems of poor disintegration and high friability, achieve good disintegration, reduce friability, and increase strength

Inactive Publication Date: 2015-12-30
李孟平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term storage of the above-mentioned vitamin E soft capsules has higher friability and poor disintegration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Step 1: Make the capsule body: inject 30Kg of glycerin and 5Kg of pure water into the sol tank, heat and stir, then add 5Kg of gelatin, 15Kg of locust bean gum, 5Kg of soybean dietary fiber, 5Kg of whey protein isolate, 1Kg of magnesium sulfate, and sunscreen 0.2Kg, 0.5Kg glycerin, 200Kg polyethylene glycol, 0.3 parts of phosphoric acid, continue stirring evenly, vacuum defoaming, stirring and heating at 60°C, and obtain the capsule material;

[0025] Step 2: Mix 15Kg of vitamin E, 1Kg of mannose, 3Kg of alginate, 40015Kg of polyethylene glycol and 5Kg of glycerin. The temperature during mixing is 50°C, the mixing time is 20min, and the colloid mill is passed through the colloid mill. The number of colloid mills is 1 times to obtain a homogeneously mixed content;

[0026] Step 3: The content obtained in step 2 and the capsule body material obtained in step 1 are subjected to the steps of pressing pills, shaping, washing pills, drying, sorting pills and subpackaging to p...

Embodiment 2

[0028] Step 1: Make the capsule body: inject 45Kg of glycerin and 10Kg of pure water into the sol tank, heat and stir, then add 10Kg of gelatin, 20Kg of locust bean gum, 10Kg of soybean dietary fiber, 10Kg of whey protein isolate, 2Kg of magnesium sulfate, and a sunscreen 0.4Kg, glycerin 0.8Kg, polyethylene glycol 2005Kg, phosphoric acid 0.5Kg, continue to stir evenly, vacuum defoaming, stirring and heating temperature is 70°C, and the capsule material is produced;

[0029] Step 2: Mix 20Kg of vitamin E, 2Kg of mannose, 5Kg of alginate, 40030Kg of polyethylene glycol and 15Kg of glycerin. The temperature during mixing is 70°C, the mixing time is 40min, and the colloid mill is passed through the colloid mill. The number of colloid mills is 3 times to obtain a homogeneously mixed content;

[0030] Step 3: The content obtained in step 2 and the capsule body material obtained in step 1 are subjected to the steps of pressing pills, shaping, washing pills, drying, sorting pills and ...

Embodiment 3

[0032] Step 1: Make the capsule: inject 40Kg of glycerin and 8Kg of pure water into the sol tank, heat and stir, then add 8Kg of gelatin, 16Kg of locust bean gum, 6Kg of soybean dietary fiber, 6Kg of whey protein isolate, 2Kg of magnesium sulfate, and sunscreen 0.3Kg, glycerin 0.6Kg, polyethylene glycol 2004Kg, phosphoric acid 0.4Kg, continue to stir evenly, vacuum defoaming, stirring and heating temperature is 65 ℃, and the capsule material is produced;

[0033] Step 2: Mix 18Kg of vitamin E, 1Kg of mannose, 4Kg of alginate, 40020Kg of polyethylene glycol and 10Kg of glycerin. The temperature during mixing is 60°C, the mixing time is 30min, and the colloid mill is passed through the colloid mill. The number of colloid mills is 2 times to obtain a homogeneously mixed content;

[0034] Step 3: The content obtained in step 2 and the capsule body material obtained in step 1 are subjected to the steps of pressing pills, shaping, washing pills, drying, sorting pills and subpackagin...

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Abstract

The invention relates to a preparation method of vitamin E soft capsules with good stability and belongs to the technical field of pharmaceutical preparations. The method comprises steps as follows: glycerin and pure water are injected into a sol tank, heated and stirred, then gelatin, edible gum, dietary fiber, whey protein, magnesium sulfate, a light-screening agent, a plasticizer, a softener and an acidity regulator are added, the mixture is continuously and evenly stirred and then subjected to vacuum defoaming, and a capsule body material is prepared; vitamin E, glucose mannose, sodium alginate, polyethylene glycol and glycerin are mixed and pass through a colloid mill, and an evenly mixed content is obtained; the obtained content and the capsule body material are subjected to steps of pelleting, shaping, pellet washing, drying, pellet picking and sub-packaging, and the vitamin E soft capsules are prepared. According to the soft capsules, the whey protein is added to be combined with inorganic salt for denaturation under the acidic condition, so that the strength of shells of the soft capsules can be improved, and the shells have the reduced friability and keep the better disintegration property.

Description

technical field [0001] The invention relates to a method for preparing vitamin E soft capsules with good stability, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Soft capsules (also known as capsules): refer to the dosage forms made by sealing a certain amount of medicinal liquid (or medicinal material extract) and suitable auxiliary materials in soft capsules of various shapes. The capsule material is made of gelatin, glycerin, water or other suitable medicinal materials. The capsule shell is soft, elastic and has a high water content. [0003] Soft capsules have the characteristics of covering bad smell, reducing irritation, high stability, anti-oxidation, convenient taking, and high bioavailability. The advantages of soft capsules are: 1. After disintegration, they can be directly absorbed in the intestinal tract without dissolving process, and the absorption is fast; 2. The content of soft capsules is accurate; 3. Hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/355A61K47/42
Inventor 李孟平
Owner 李孟平
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