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Preparation technology of glucuronolactone

A technology of glucuronolactone and preparation process, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of low product yield, unsatisfactory purity, difficult crystallization, etc. Yield and purity, the effect of improving purity and yield, and reducing production cost

Active Publication Date: 2015-12-30
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucuronide can be obtained according to ZL200810151100.9. (clean production method of glucuronolactone), ZL200910023005.5. (crystallization method of D-glucuronic acid-γ-lactone) and 2014101006471 (crystallization method of glucuronolactone at room temperature) Acid lactone, but there are technical problems such as difficult crystallization, low product yield, and purity that cannot meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Preparation of oxidized starch

[0027] Add 300mL of deionized water into the three-necked flask, add 150g of potato starch while stirring, adjust the pH value of the system to 10 with 2mol / L NaOH, and add 45mL of H 2 o 2 , 2.4g of FeSO 4 , reacted for 4 hours at a pH value of 10, filtered while hot, put the filter cake (oxidized starch) in a beaker, added 2mol / L HCl to soak for 3 hours, stirred and filtered, put the filter cake in a beaker, and stirred While adding 300mL of deionized water, stir and filter, in the same way, wash the filter cake with deionized water until the filtrate is neutral and does not contain Cl - , dry oxidized starch;

[0028] 2) Enzymolysis

[0029] According to the ratio of adding 150mL of deionized water to 75g of oxidized starch, add deionized water to the oxidized starch while stirring to obtain an oxidized starch emulsion, adjust the pH value to 6.5, add 12mL of liquefying enzyme, hydrolyze at 85°C for 1 hour, and adjust the pH Wh...

Embodiment 2

[0037] 1) Preparation of oxidized starch

[0038] Add 300mL of deionized water into the three-necked flask, add 150g of potato starch while stirring, adjust the pH of the system to 9.5 with 2mol / L NaOH, and add 43mL of H 2 o 2 , 2.3g of FeSO 4 , reacted for 4 hours at a pH value of 10, filtered while it was hot, placed the filter cake (oxidized starch) in a beaker, added 1.5mol / L HCl to soak for 3.5 hours, stirred and filtered, placed the filter cake in a beaker, Add 300mL of deionized water while stirring, stir and filter, in the same way, wash the filter cake with deionized water until the filtrate is neutral and does not contain Cl - , dry oxidized starch.

[0039] 2) Enzymolysis

[0040] According to the ratio of adding 150 mL of deionized water to 75 g of oxidized starch, add deionized water to the oxidized starch while stirring to obtain an oxidized starch emulsion, adjust the pH value to 6.5, add 10 mL of liquefying enzyme, hydrolyze at 85 ° C for 0.5 h, adjust The...

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PUM

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Abstract

The invention discloses a preparation technology of glucuronolactone, and belongs to the field of medicine raw material production. According to the preparation technology, acid pickling and water washing are mainly carried out on oxidized starch to remove impurities in the oxidized starch, the liquification and saccharification of the oxidized starch are faciliated, glycuronic acid, glucose, disaccharide and trisaccharide are obtained after the saccharification of the oxidized starch; by virtue of the property that glycuronic acid is easy to dissolve in ethyl alcohol (alcohol), but the glucose, disaccharide and trisaccharide are insoluble in alcohol, the glycuronic acid is subjected to separation and purification, so that the fermentation and impurity-removal technology is eliminated, and the production period is shortened by 72 h. The technology is simple in operation, short in reaction time, and low in requirements for equipment; the glucuronolactone prepared by the technology is high in yield and high in purity.

Description

technical field [0001] The invention belongs to the field of pharmaceutical raw material production, and in particular relates to a preparation process of high-purity glucuronolactone. Background technique [0002] Glucuronolactone is a good medicine for treating hepatitis, liver cirrhosis and connective tissue diseases. my country is the main producer of glucuronolactone. With the increasingly prominent environmental problems, the traditional method of nitric acid oxidation to produce glucuronolactone is challenged. Yuan Hua’s research group at Huazhong University of Science and Technology, on the basis of foreign technology, adopted the technology of loading precious metals to produce oxidized starch. Although the pollution problem in the production of oxidized starch was solved, the hydrolysis of oxidized starch was still produced by acid hydrolysis, and pollution still existed. Due to the low content of carboxyl groups in oxidized starch and incomplete oxidation, the hy...

Claims

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Application Information

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IPC IPC(8): C07H13/02C07H1/00
Inventor 李祥王丽萍师春兰豆静茹马倩鹤蔺旺梅卢睿
Owner SHAANXI UNIV OF SCI & TECH
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