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A technology of oral care and gel, which is applied in the field of oral care gel and its preparation, can solve the problems of oral care gel losing anti-inflammation and sterilization, destroying oral microecological balance, etc., so as to increase the curative effect of drugs, alleviate oral problems, Prevention and effect of oral problems
Inactive Publication Date: 2016-01-06
天津小优科技有限公司
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Problems solved by technology
Traditional oral care gels use broad-spectrum antibiotics and chemical synthetic drugs to remove pathogenic bacteria, but long-term use of these drugs will destroy the oral micro-eco
Method used
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Embodiment 1
[0015]
[0016]
[0017] Preparation method: put carbomer and sodium hyaluronate into purified water to swell naturally, stir the swollen liquid evenly, adjust the pH value to neutral with triethanolamine, and form a gel matrix, then add glycerin, phenoxyethanol , ethylhexylglycerin and methylparaben to prepare a solution; add the solution to the carbomer and sodium hyaluronate gel base solution, stir and mix well to obtain a translucent gel.
Embodiment 2
[0019]
[0020] Preparation method: put carbomer and sodium hyaluronate into purified water to swell naturally, stir the swollen liquid evenly, adjust the pH value to neutral with triethanolamine, and form a gel matrix, then add glycerin, phenoxyethanol , ethylhexylglycerin and methylparaben to prepare a solution; add the solution to the carbomer and sodium hyaluronate gel base solution, stir and mix well to obtain a translucent gel.
Embodiment 3
[0022] The oral care gel obtained in Example 1 is recorded as 1#, the oral care gel obtained in Example 2 is recorded as 2#, and the quality and biological evaluation tests are carried out on 1# and 2#.
[0023] (1) content
[0024] Oral care gels 1# and 2# were measured according to the sodium hyaluronate content determination method, and the sodium hyaluronate content was 90.0%-120.0% of the marked mass concentration value.
[0025] (2)pH value
[0026] Oral care gel 1#, 2# are diluted with distilled water in equal mass ratio, and are measured according to the method specified in two VIH of "Pharmacopoeia of the People's Republic of China" (2010 edition), the pH value of oral care gel 1#, 2# is equal to Within the range of 6.8-7.5, it meets the requirements.
[0027] (3) Osmotic pressure
[0028] Oral care gel 1#, 2# are directly sampled, and are measured according to the method of two appendix IX G of " Pharmacopoeia of the People's Republic of China " (2010 edition), an...
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Abstract
The invention aims to provide oral-care gel. The oral-care gel comprises purified water, glycerol, carbomer, sodium hyaluronate, triethanolamine, ethylhexylglycerin, phenoxyethanol and methyl hydroxybenzoate, wherein the purified water accounts for 70%-95% of the total weight of the gel, the glycerol accounts for 5%-15% of the total weight of the gel, the carbomer accounts for 0.8%-2.2% of the total weight of the gel, the sodium hyaluronate accounts from 0.1%-2% of the total weight of the gel, the triethanolamine is a pH (potential of hydrogen) modifier and can adjust the pH to be neutral, the ethylhexylglycerin accounts for 0.2%-0.4% of the total weight of the gel, the phenoxyethanol accounts for 0.2%-0.4% of the total weight of the gel, and the methyl hydroxybenzoate accounts for 0.1%-0.2% of the total weight of the gel. The oral-care gel has the benefits as follows: sodium hyaluronate oligosaccharide with a low molecular weight is taken as an anti-inflammation agent, the carbomer is adopted to serve as a gel matrix and also serve as a medicine carrier, and the sodium hyaluronate oligosaccharide is sent to all the pathological parts in a targeting manner and located at acting parts and is slowly released; the oral-care gel can be anti-inflammatory and anti-bacterial and promote restoration and regeneration of oral mucosa and tissue and effectively prevents and relieves oral cavity problems.
Description
technical field [0001] The invention relates to the field of oral care, in particular to an oral care gel and a preparation method thereof. Background technique [0002] The oral cavity is the gateway for microorganisms to enter the respiratory tract, digestive tract, and blood. Due to the special structural and physiological characteristics of the oral cavity, the oral cavity is colonized with a complex microbial community. Under normal circumstances, close and complex interactions between oral microbial communities and between microorganisms and the host maintain the health of the host. If this ecological balance is broken, it will cause disease. Oral microbiome is closely related to major oral diseases and some systemic diseases. Frequently occurring diseases in the oral cavity include dental caries, periodontal diseases (including gingivitis, periodontitis, etc.), oral mucosal diseases (oral ulcers, recurrent aphthous ulcers, lichen planus, cheilitis, etc.). These or...
Claims
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