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Oxybutynin hydrochloride sustained-release capsule and preparation method thereof

A technology of oxybutynin hydrochloride and sustained-release capsules, which is applied in the field of capsules and its preparation, can solve the problems of frequent doses, large fluctuations in blood drug concentration, and large side effects, and achieve reduced doses, stable release curves, and reduced side effects Effect

Active Publication Date: 2016-01-06
上海爱的发制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets are taken more times, the blood concentration fluctuates greatly, and the side effects are large

Method used

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  • Oxybutynin hydrochloride sustained-release capsule and preparation method thereof

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Embodiment Construction

[0014] The preferred embodiments of the present invention are given below in conjunction with the accompanying drawings to describe the technical solution of the present invention in detail.

[0015] Oxybutynin hydrochloride sustained-release capsules of the present invention are composed of the following components, calculated by weight percentage, 6.8% oxybutynin hydrochloride, 86.8% sugar pills, 1.3% hypromellose, 0.3% 35% Dimethicone emulsion, 3.7% ethyl cellulose aqueous dispersion, 0.8% dibutyl sebacate, 0.3% talc.

[0016] The hypromellose is a binder. The 35% (35% is the mass percentage, that is, 100 parts of the emulsion contains 35 parts of dimethicone) dimethicone emulsion is a water blocking agent, which prevents the water-soluble main ingredient from being absorbed during the coating operation. Penetrates into the coating film. The ethyl cellulose aqueous dispersion is a coating agent. The dibutyl sebacate is a plasticizer. Described talcum powder is lubricant...

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Abstract

The invention discloses an oxybutynin hydrochloride sustained-release capsule and a preparation method thereof. The oxybutynin hydrochloride sustained-release capsule is prepared from, by weight, 6.8% of oxybutynin hydrochloride, 86.8% of sugared pills, 1.3% of hydroxypropyl methylcellulose, 0.3% of 35% dimethicone emulsion, 3.7% of aqueous ethylcellulose dispersion, 0.8% of sebacic acid dibutyl ester and 0.3% of talcum powder. By means of the oxybutynin hydrochloride sustained-release capsule, effective blood concentration can be kept in vivo, no peak valley phenomenon is caused, side effects caused when the blood concentration is too high are relatively reduced, and meanwhile the non-treatment effect caused when the blood concentration is too low is reduced; the number of medicine taking times in each day is decreased, and the medicine taking compliance of patients is improved.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to an oxybutynin hydrochloride sustained-release capsule and a preparation method thereof. Background technique [0002] Oxybutynin is a relaxant of urinary tract smooth muscle with mild anticholinergic and strong antispasmodic effects. It can selectively act on the detrusor muscle of the bladder, reduce bladder internal pressure, increase capacity, reduce involuntary bladder contraction, relieve urgency, frequency and incontinence. Oxybutynin is a major advance in the treatment of urinary incontinence, diseases that are becoming more prevalent with an aging population, such as prostate and bladder cancer, lower urinary tract symptoms in men, and urinary incontinence. [0003] At present, ordinary tablets are commonly used in clinical practice in China. The usual oral dose is 5 mg once, 2 to 3 times a day, and the maximum dose is 5 mg once, 4 times a day. Ordinary ta...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/38A61P13/00
Inventor 雷迪克
Owner 上海爱的发制药有限公司
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