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Multifunctional nanomaterials with metal-organic framework mesoporous structure and preparation method

A technology of metal-organic framework and mesoporous structure, which is applied in the field of preparation of nanocomposite materials, can solve the problems of differential thermal stability and chemical stability, and achieve high stability, easy production and promotion, and simple and easy preparation process Effect

Active Publication Date: 2017-11-21
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, they all have various limitations, such as poor thermal and chemical stability, rapid decomposition in the immune system, etc.

Method used

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  • Multifunctional nanomaterials with metal-organic framework mesoporous structure and preparation method
  • Multifunctional nanomaterials with metal-organic framework mesoporous structure and preparation method
  • Multifunctional nanomaterials with metal-organic framework mesoporous structure and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment ( 1

[0022] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: First, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mL NaOH is dissolved in 8mL diethylene glycol (DEG), the solution is heated to 120°C and maintained for 1h under stirring, then cooled to 70°C stand-by. Then 0.576g polyacrylic acid (PAA) and 1.08g FeCl 3 After dissolving in 30mL DEG to form a transparent solution, heat to 220°C with stirring in the presence of nitrogen, when the color of the mixture in the flask turns light yellow, quickly inject 2mL NaOH / DEG mixed solution into it under stirring , kept at 220°C for 2h and then cooled to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloid clusters with a diameter of about 10 nm.

[0023] (2) The reaction of aqueous solution at room temperat...

Embodiment ( 2

[0026] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: Firstly, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mL NaOH is dissolved in 6mL diethylene glycol (DEG), the solution is heated to 120°C and maintained under stirring for 1h, then cooled to 70°C stand-by. Then 0.5g polyacrylic acid (PAA) and 0.9g FeCl 3 After dissolving in 28mL DEG to form a transparent solution, heat to 220°C with stirring in the presence of nitrogen. When the color of the mixture in the flask turns light yellow, quickly inject 2.5mL NaOH / DEG mixed solution into it under stirring , kept at 220°C for 2h and then cooled to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloid clusters with a diameter of about 30 nm.

[0027] (2) The reaction of aqueous solution at room tempera...

Embodiment ( 3

[0030] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: First, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mL NaOH is dissolved in 10mL diethylene glycol (DEG), the solution is heated to 120°C and maintained under stirring for 1h, then cooled to 70°C stand-by. Then 0.6g polyacrylic acid (PAA) and 1.5g FeCl 3 After dissolving in 34mL DEG to form a transparent solution, heat to 220°C with stirring in the presence of nitrogen, when the color of the mixture in the flask turns light yellow, quickly inject 3.5mL NaOH / DEG mixed solution into it under stirring , kept at 220°C for 2h and then cooled to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloidal clusters with a particle size of about 70 nm.

[0031] (2) The reaction of aqueous solution at room t...

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Abstract

The invention provides a multifunctional nanometer material with a metal organic framework mesoporous structure and a preparation method. The MOFs mesoporous nanomaterial with high stability, good dispersion and excellent hydrophilicity prepared by the combination of high temperature pyrolysis and electrostatic adsorption method not only provides a large surface area for introducing a large number of functional molecular groups, but also provides Absorbing and encapsulating biomolecules provides a larger pore size; using Fe3O4 as a photothermal reagent and targeting reagent, through the response to external magnetic fields and infrared light sources, cancer cells can be targeted and photothermally treated; Au25 is used as a photosensitizer , can be directly sensitized by infrared photosensitization to generate a large amount of singlet oxygen, and then play an anti-cancer role; by changing the amount of reactants, a multifunctional nanocomposite material with MOFs structure of different sizes can be synthesized.

Description

technical field [0001] The invention relates to a nanocomposite material. The invention also relates to a preparation method of the nanocomposite material. Background technique [0002] Drug carrier is one of the most important and attractive research fields, and carrier is the most critical for controlling drug storage capacity and its functional effect. In the last decade, this research has been greatly improved, and in the drug carrier system, a large number of organic systems have been investigated as drug carrier candidates, such as micelles, liposomes and polymers. However, they all have various limitations, such as poor thermal and chemical stability, rapid breakdown in the immune system, etc. In contrast, inorganic-organic hybrid mesoporous materials have good biocompatibility, stable selectivity and non-toxicity, so they have great potential as adjuvants in pharmaceutical technology. [0003] As we all know, mesoporous materials are one of the most important carr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/24A61K47/04A61K41/00A61P35/00
Inventor 杨飘萍杨丹盖世丽杨桂欣毕惠婷徐加廷冯莉莉
Owner HARBIN ENG UNIV
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