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Application of daphne odora preparation in preparation of pre-hospital burn and scald care solutions

A technology of burns and scalds, Ruixiang prescription, applied in the field of medicine, can solve the problem that the anti-infection and healing-promoting drugs are rarely reported, etc.

Inactive Publication Date: 2016-01-13
赵秋霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of external prescriptions and medicines for the treatment of burn infected wounds, and the therapeutic effect of Chinese herbal medicines has also been reported, but the anti-infection and healing-promoting medicines used in pre-hospital emergency care of burns and scalds are rarely reported

Method used

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  • Application of daphne odora preparation in preparation of pre-hospital burn and scald care solutions
  • Application of daphne odora preparation in preparation of pre-hospital burn and scald care solutions
  • Application of daphne odora preparation in preparation of pre-hospital burn and scald care solutions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0014] Weigh 0.9kg daphne flower, 2.3kg juhuacao, 1.5kg big golden cow grass, 0.9kg single flower mangosteen, 0.9kg seven claw wind, 2.3kg sugarcane skin, 2.3kg Pulsatilla chinensis, 0.9kg stretching grass, 0.9kg green bamboo label, 0.9kg of snake aconite, 0.9kg of Chuan Phellodendron, 0.5kg of woody incense, combined, add water to decoct twice, add water for the first time to 12 times the total weight of the medicinal materials, boil with high fire and simmer for 2 hours, add water for the second time to obtain the total weight of the medicinal materials. 10 times the weight, boiled with strong fire and decocted with slow fire for 1.5h, combined decoction, concentrated under reduced pressure at 0.08MPa and 70°C to 70°C, the relative density was about 1.15, and 95% ethanol was added to make the volume alcohol content reach Stir after 75%, let it stand overnight, filter, concentrate the filtrate under...

Embodiment 2

[0015] Embodiment 2: the preparation of Chinese medicine nursing solution

[0016] Weigh the dry Chinese medicine paste powder prepared in Example 1, add appropriate amount of distilled water to dissolve, and prepare an aqueous solution with a concentration of 150 mg / mL, which is the Chinese medicine care solution, and is used for rat skin irritation test and pharmacodynamic test.

Embodiment 3

[0017] Embodiment 3: Rat skin irritation test

[0018] 16 healthy SD rats, body weight 220-260g, half male and half female. The rats were randomly and equally divided into two groups: normal saline group and nursing solution group, with 8 rats in each group. Use 8% sodium sulfide to depilate on one side of the back of the rat, and the depilatory area is 3cm * 3cm; Get a certain amount of 100mg / mL Chinese medicine nursing solution (prepared in embodiment 2) respectively as a drug group, with normal saline as contrast, in large Apply the drug to the depilated area of ​​the mouse. After 24 hours of administration, wash away the residual drug with warm water, observe whether there is erythema and edema at the administration site at 1, 24, and 48 hours after removing the drug, score according to Table 1, and evaluate the stimulation intensity according to Table 2.

[0019] Table 1 Scale of skin irritation reaction

[0020]

[0021] Table 2 Reaction order evaluation

[0022] ...

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Abstract

The invention discloses application of a daphne odora preparation in preparation of pre-hospital burn and scald care solutions. The daphne odora preparation is prepared from, by weight, 6-12 parts of daphne odora, 18-30 parts of floscopa scandens, 11-19 parts of polygala glomerata, 6-12 parts of garcinia oligantha, 6-12 parts of rubus reflexus Ker. var. lanceolobus metc., 18-30 parts of sugarcane peels, 18-30 parts of pulsatilla chinensis, 6-12 parts of lycopodium clavatum, 6-12 parts of scindapsus officinalis schott, 6-12 parts of tetrastigma hemsleyanum, 6-12 parts of phellodendron chinense schneid and 3-7 parts of aucklandia lappa. The daphne odora preparation aqueous extract has preventive and therapeutic effect on burn and scald infection, can quicken healing of burned and scalded wounds and is suitable for being developed into the pre-hospital care solutions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Daphne Fragrance Prescription in the preparation of pre-hospital emergency care solution for burns and scalds and the extract of Daphne Fragrance Prescription. Background technique [0002] Burns refer to damage to body surface tissue due to heat such as boiling water (oil, soup), hot metal (liquid or solid), flame, steam, and high-temperature gas. It is also a common traumatic disease in daily life. Burn and scald wounds are easily infected by bacteria. Therefore, the key issue in treatment is to prevent wound infection in advance. Failure to receive timely and reasonable treatment will cause serious consequences for patients, and even sepsis, which is life-threatening. [0003] In recent years, the level of medical treatment of burns in my country has been continuously improved, and the mortality rate of burn shock has decreased significantly. Ho...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P17/02
Inventor 赵秋霞刘冉
Owner 赵秋霞
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