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Preparing technology for tablet-type doxycycline hyclate

A technology for preparing doxycycline hydrochloride and a preparation process, which is applied in the field of preparation of tablet-type doxycycline hydrochloride, can solve problems such as slow dissolution speed, achieve the effects of facilitating dissolution, improving dissolution speed, and overcoming slow dissolution speed

Inactive Publication Date: 2016-01-20
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation process of tablet-type doxycycline hydrochloride, to overcome the problem that the existing doxycycline hydrochloride preparations dissolve slowly in the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation technology of tablet formula doxycycline hydrochloride comprises the following steps:

[0022] 1) Preparation of doxycycline hydrochloride: Grind 5 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The content is 15%; Dissolve 10g of ethyl cellulose in ethanol to form solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A will form emulsion C after solution B is dispersed; gelatin Dissolve in distilled water in a 60°C water bath to make a protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to the protection solution D under stirring to form a solution E, raise the water bath from 30°C to 50°C, and stir The organic solvent is volatilized; then E is suction-filtered and washed with water to obtain a doxycycline hydrochloride wet product; then dried to o...

Embodiment 2

[0026] The preparation technology of tablet formula doxycycline hydrochloride comprises the following steps:

[0027] 1) Preparation of doxycycline hydrochloride: Grind 5 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The content is 20%; Dissolve 15g of ethyl cellulose in ethylene glycol to form solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A forms emulsion C after solution B is dispersed; Dissolve gelatin and distilled water in an 80°C water bath to make protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to protection solution D under stirring to form solution E, and raise the water bath from 30°C to 50°C , stirred to volatilize the organic solvent, then E was suction filtered and washed to obtain a doxycycline hydrochloride wet product; then dried to obtain a w...

Embodiment 3

[0031] The preparation technology of tablet formula doxycycline hydrochloride comprises the following steps:

[0032] 1) Preparation of doxycycline hydrochloride: Grind 6 g of doxycycline hydrochloride into powder with a ball mill, then dissolve the powder in water to form solution A; the percentage of doxycycline in the doxycycline hydrochloride The content is 25%; Dissolve 12g of ethyl cellulose in dichloromethane to configure solution B; under the premise of stirring, gradually pour solution A into solution B, and solution A forms emulsion C after solution B is dispersed; Dissolve gelatin and distilled water in a 70°C water bath to make protection solution D, keep the temperature at 30°C for use; add emulsion C dropwise to protection solution D under stirring to form solution E, and raise the water bath from 30°C to 50°C , stirring to volatilize the organic solvent; then E is suction filtered and washed to obtain a doxycycline hydrochloride wet product; then dried to obtain...

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Abstract

The invention relates to a preparing technology for tablet-type doxycycline hyclate. The preparing technology includes the following steps that doxycycline hyclate is grinded into powder through a ball mill, and the powder is dissolved into water to be prepared into a solution A; ethyl cellulose is dissolved into an organic solvent to be prepared into a solution B; the solution A is slowly poured into the solution B on the stirring premise, and an emulsion C is formed after the solution A is dispersed in the solution B; gelatin is dissolved into distilled water in a water bath at the temperature of 60 DEG C to 80 DEG C to be prepared into protective fluid D, and the protective fluid D is ready for use at the constant temperature of 30 DEG C; the emulsion C is dropwise added into the protective fluid D on the stirring premise to form a solution E, the temperature of the water bath is increased from 30 DEG C to 50 DEG C, and stirring is carried out to volatize the organic solvent; then the E is subjected to suction filtration, washing and drying, white-powder-type doxycycline hyclate is obtained, and the doxycycline hyclate powder and an auxiliary material are mixed and pressed into tablets. By means of the preparing technology, the problem that an existing doxycycline hyclate preparation is low in dissolving speed in the preparing process is solved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation process of tablet doxycycline hydrochloride. Background technique [0002] Doxycycline hydrochloride is a broad-spectrum semi-synthetic tetracycline antibiotic. Its antibacterial spectrum is similar to that of tetracycline, but its antibacterial effect is 10 times stronger. The medicine has strong water solubility, good absorption and wide distribution, and has many clinical applications and good effects. Microorganisms have close cross-resistance to this drug and tetracycline, oxytetracycline, etc. Oral absorption is good. It is mainly used for upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, etc. caused by sensitive gram-positive bacteria and gram-negative bacilli. Wait. It can still be used to treat cholera, and also to prevent falciparum malaria and leptospirosis infection. Clinical veterinary medicine is ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/65A61P31/04A61P11/00
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM