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Drug-resistant microbe and variant microbe disinfectant containing chlorous acid aqueous solution

A chlorous acid aqueous solution, the technology of resistant bacteria, applied in the direction of chlorous acid, disinfectant, chlorite, etc., to achieve high-efficiency disinfection ability, the effect of reliable human body

Inactive Publication Date: 2016-01-20
HONBU SANKEI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So resistance is a problem with antibiotics

Method used

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  • Drug-resistant microbe and variant microbe disinfectant containing chlorous acid aqueous solution
  • Drug-resistant microbe and variant microbe disinfectant containing chlorous acid aqueous solution
  • Drug-resistant microbe and variant microbe disinfectant containing chlorous acid aqueous solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] (Example 1: Preparation of chlorous acid aqueous solution)

[0138] The aqueous chlorous acid formulations used in the following examples are prepared as follows. In this article, the abbreviation "CAAS" is used in the case of aqueous chlorous acid. However, they have the same meaning.

[0139] Composition analysis table of chlorous acid aqueous solution

[0140] [Table 2]

[0141]

[0142]

[0143] An aqueous chlorous acid solution based on the following blend was used to prepare an aqueous chlorous acid solution formulation.

[0144] [table 3]

[0145]

[0146] [Table 4]

[0147] CAAS specification

Chlorous acid aqueous solution preparation prepared with chlorous acid aqueous solution

Content

3.0％

Attributes

Yellow

Confirmation test (1)

Match

Confirmation test (2)

Matching (the curve of absorbance and wavelength is shown in Figure 8 In)

Confirmation test (3)

Match

Purity test (1)

Below detection limit

Purity test (2)

Below detection limit

[0148] (M...

Embodiment 2

[0155] (Example 2: Effect on methicillin-resistant Staphylococcus aureus COL)

[0156] In this example, the effect on methicillin-resistant Staphylococcus aureus was tested. The method is as described above ((Method of measuring sterilization (bacterial sterilization))). The results are shown in Figure 2.

[0157] As shown in the figure, it is proved that MRSA is mostly sterilized at 100 ppm or higher. We found that MRSA is completely sterilized at 100 ppm in a neutral to alkaline zone with a high pH of 6.5 or higher. As can be seen from the above, the neutral to alkaline region is understood to be preferable for Gram-positive bacteria such as MRSA compared to the existing knowledge. More specifically, we found that MRSA is completely sterilized at 100 ppm in a neutral zone with a high pH of 6.5 to 8.5, and considering the difference from sodium chlorite, the pH is 6.5 or higher and less than 7.0. As can be seen from the above, the pH in the neutral zone is understood to be pre...

Embodiment 3

[0158] (Example 3: Effect on Multidrug-resistant Pseudomonas aeruginosa TUH)

[0159] In this example, the effect on multi-drug resistant Pseudomonas aeruginosa was tested. The method is as described above ((Method of measuring sterilization (bacterial sterilization))). The results are shown in Figure 3.

[0160] As shown in the figure, it is proved that MDRP is mostly sterilized at 100 ppm or higher, and is completely sterilized at 500 ppm. In particular, we found that MDRP was completely sterilized even at 50 ppm in an acidic zone with a low pH of 6.5 or higher. It can be seen from the above that compared with the prior knowledge, it has been found that the antibacterial effect has a preferred pH that differs depending on the bacteria.

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PUM

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Abstract

The present invention provides microbe disinfectants, providing: Drug-resistant microbe disinfectants comprising a chlorous acid aqueous solution for inactivating microbes selected from methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and vancomycin-resistant Enterococcus; and microbe disinfectants, which are made with acidity when applied to gram-negative microbes and with alkalinity when applied to gram-positive microbes. The microbes comprise at least one species of microbes selected from the group consisting of E. coli, Staphylococcus aureus, microbes of genus Bacillus, microbes of genus Paenibacillus, Pseudomonas aeruginosa, Enterococcus, Salmonella enterica, and periodontal disease microbes. The present invention is usable as a microbe disinfectant that is safe to human body and easy to handle as a microbe disinfectant for pretreatment in food processing and produces chlorous acid that generates little chlorine dioxide. The microbe disinfectant comprising a chlorous acid aqueous solution of the present invention can be utilized as a sterilizing agent, food additive, antiseptic, quasi-drug, medicine, etc.

Description

Technical field [0001] The present invention relates to a disinfectant for resistant bacteria containing an aqueous chlorous acid solution. [0002] The present invention relates to a mutant bacteria disinfectant containing an aqueous chlorous acid solution. Background technique [0003] The problem of drug-resistant bacteria is both old and new. Although antibiotics are excellent drugs, the problem associated with them is that the target bacteria gradually acquire resistance. Historically, from the time when Staphylococcus aureus acquired resistance to penicillin (penicillin-resistant Staphylococcus aureus) in the 1950s, it was discovered that resistance to methicillin was acquired in the 1970s. Sex (Methicillin-resistant Staphylococcus aureus). Thereafter, resistance to vancomycin was discovered in the 1990s (in 1997, vancomycin-resistant Enterococcus (VRE), vancomycin-resistant Staphylococcus aureus (VISA)) . In addition, vancomycin-resistant Staphylococcus aureus was repor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/00A01N59/08A61K33/14C01B11/08A01P1/00A61Q11/02A61K33/20
CPCA61Q11/00A61Q17/005A61K8/20A61K33/20C01B11/022C01B11/08A01N59/00A61P31/00Y02A50/30A01N25/02
Inventor 合田学刚
Owner HONBU SANKEI
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