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Poly(lactic-co-glycollic acid) complex and preparation method thereof

A technology of glycolic acid and compound, applied in the field of poly(lactic acid-glycolic acid) compound and its preparation, can solve the problem of limited progress of cancer, achieve good water solubility and biocompatibility, good dispersibility, and tumor inhibition The effect of cell spreading

Active Publication Date: 2016-01-27
JE & NA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Cancer is one of the major malignant diseases that threaten human health. Since the 1950s, a lot of human, material and financial resources have been invested in the prevention and treatment of cancer for decades, but the progress made in the treatment of cancer is very small. limited

Method used

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  • Poly(lactic-co-glycollic acid) complex and preparation method thereof
  • Poly(lactic-co-glycollic acid) complex and preparation method thereof
  • Poly(lactic-co-glycollic acid) complex and preparation method thereof

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preparation example Construction

[0044] The invention provides a kind of preparation method of poly(lactic acid-glycolic acid) compound, comprising:

[0045] After mixing the poly(lactic acid-glycolic acid) solution and the mixed solution, ultrasonic treatment is performed to obtain a poly(lactic acid-glycolic acid) complex;

[0046] The mixed solution contains indocyanine green and imidazoquinoline compounds.

[0047] In an embodiment of the present invention, under the action of a dispersant, the poly(lactic acid-glycolic acid) solution and the mixed solution may be mixed and then subjected to ultrasonic treatment to obtain a poly(lactic acid-glycolic acid) composite. In an embodiment of the present invention, the poly(lactic acid-glycolic acid) solution, the mixed solution and the dispersant can be mixed and then subjected to ultrasonic treatment to obtain a poly(lactic acid-glycolic acid) compound; in another embodiment, the The mixed liquid and the dispersant are added into the poly(lactic acid-glycolic...

Embodiment 1

[0058] Indocyanine Green (ICG) and imidazoquinoline compound (R837) were dissolved in dimethyl sulfoxide (DMSO) to obtain a mixed solution, the concentration of ICG in the mixed solution was 10 mg / mL, and the concentration of R837 was 5 mg / mL mL; Dissolve 5 mg of poly(lactic acid-glycolic acid) (PLGA) in 1 mL of dichloromethane to obtain a PLGA solution; add 19 μL R837 solution and 6.25 μL ICG solution to the above mixed solution and polyvinyl acetate (PVA) was mixed and subjected to ultrasonic treatment for 20 minutes under 100W power, then stirred for 4 hours to obtain a stirred product; the stirred product was centrifuged at 3500 g for 20 min, and the supernatant was taken to remove poly(lactic acid-glycolic acid) that did not form particles , indocyanine green and imidazoquinoline compounds, and then use a 100KD ultrafiltration tube to carry out ultrafiltration to remove organic solvents and polyvinyl acetate to obtain poly(lactic acid-glycolic acid) complexes.

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Abstract

The invention provides a poly(lactic-co-glycollic acid) complex, comprising a matrix prepared from an indocyanine green and imidazoquinoline compound, and poly(lactic-co-glycollic acid) covering the outside of the matrix. The poly(lactic-co-glycollic acid) complex has better optical absorption performance in a near-infrared area and can generate heat in laser irradiation to kill primary tumors, fragments of tumor cells can serve as an antigen to trigger further antitumor immune reaction; the poly(lactic-co-glycollic acid) complex can inhibit the activity of regulatory T cells under the action of an immunosuppressor; the poly(lactic-co-glycollic acid) complex enables photothermal therapy and immune therapy to be synergistic, the growth of secondary tumors is inhibited, and tumor cell metastasis can also be inhibited. The invention also provides a preparation method of the poly(lactic-co-glycollic acid) complex.

Description

technical field [0001] The invention relates to the technical field of poly(lactic acid-glycolic acid), in particular to a poly(lactic acid-glycolic acid) compound and a preparation method thereof. Background technique [0002] Cancer is one of the major malignant diseases that threaten human health. Since the 1950s, a lot of human, material and financial resources have been invested in the prevention and treatment of cancer for decades, but the progress made in the treatment of cancer is very small. limited. [0003] In cancer treatment methods, photothermal therapy is a treatment method for thermal ablation of tumor cells. Its main principle is: under the irradiation of excitation light, the thermal effect generated by photothermal conversion is used to directly kill tumor cells. Therefore, whether strong light absorption and high photothermal conversion efficiency can be produced on cancer cells is the key factor for the success of photothermal therapy. Near-infrared li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K39/00A61K47/34A61P35/00
Inventor 刘庄陈倩
Owner JE & NA BIOTECH CO LTD