High-strength polypeptide hydrogel preparation method

Abstract

The invention relates to a high-strength polypeptide hydrogel preparation method and belongs to the field of chemical preparation. The high-strength polypeptide hydrogel preparation method includes (1) selecting polypeptide molecules, which are provided with positive charges and capable of forming long fiber structures by self-assembly, to prepare an aqueous solution, mixing uniformly ultrasonically and standing so as to enable the aqueous solution to form the long fiber structures by self-assembly; (2) adding GO (graphene oxide) lamellas into the solution of the long fiber structures, mixing uniformly ultrasonically, regulating a pH (potential of hydrogen) value, standing and forming hybrid hydrogel after a system is aged and stabilizes. The high-strength polypeptide hydrogel preparation method has the advantages that the GO lamellas are introduced into the polypeptide hydrogel, and gelling capability of the system is improved, so that a high-strength polypeptide/GO hybrid hydrogel material is obtained; properties of mechanical strength, aperture size and the like of the polypeptide/GO hybrid hydrogel can be controlled by controlling the size, surface charge density and surface charge concentration of the GO lamellas.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel, in particular to a preparation method of a high-strength polypeptide hydrogel; it belongs to the field of chemical preparation. Background technique [0002] Hydrogel is a gel material with water as the dispersion medium. Due to its rich pore structure and three-dimensional network structure that can provide better permeability and mechanical support, it has broad application prospects in many fields. In recent years, hydrogel materials have attracted the attention of scientists at home and abroad, and a lot of research has been done on their applications in biomedicine, such as tissue engineering and drug delivery. Ordinary hydrogels can be obtained by covalent cross-linking between high-molecular-weight synthetic polymers or between some small molecules, but such cross-linking methods need to be carried out by chemical synthesis. Since most of the chemical reagents are toxic, the hydrogel ...

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Problems solved by technology

This process is based on the formation of non-covalent interactions, the ability to form gels is limited, and the cross-linking strength between fibers is often low, resulting in limited gel strength, poor self-supporting performance, and easy to be destroyed; moreover, its fiber cross-linking The pore size of the three-dimensional network structure formed by the association is often small and difficult to effectively control, which greatly limits its application in the field of tissue engineering materials.

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