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Application of forsythiaside I and preparation method thereof

A technology of forsythiaside and forsythia leaf, applied in the field of application and preparation of plant extracts, can solve the problem that forsythiaside I is not well studied, preparation and preservation of forsythiaside I are difficult, and forsythiaside I Antibacterial activity is not understood and other issues

Active Publication Date: 2016-02-03
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It is precisely because of the instability of forsythiaside I that it is prone to transformation during preparation or processing, so it is difficult to prepare and store forsythiaside I. At present, there are not many studies on forsythiaside I, because forsythiaside I The specific antibacterial activity of Arthrin I is still unknown

Method used

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  • Application of forsythiaside I and preparation method thereof
  • Application of forsythiaside I and preparation method thereof
  • Application of forsythiaside I and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] The forsythiaside I is made by the following steps:

[0142] (1) Extraction: Weigh 500 g of forsythia leaves, add 10 times the amount of water to reflux and extract 3 times, each time for 1 hour, to obtain the water extract of forsythia leaves;

[0143] (2) Purification: The forsythiaside component was preliminarily purified by passing the water extract of forsythia leaves obtained in step (1) through the macroporous resin AB-8, and the ratio of resin to medicinal material was 1:0.8 (g / g), The sample loading rate is 1BV / h, followed by water, 20%, 40% ethanol gradient elution, and the 20% ethanol eluate is collected;

[0144] (3) Impurity removal: Take the eluted part of 20% ethanol obtained in step (2), use a silica gel column to remove impurities, and use ethyl acetate and absolute ethanol solvent system for elution, and calculate based on the content of forsythiaside I, The amount of sample loaded and the amount of silica gel used are 1:150 (g / g), and ethyl acetate i...

Embodiment 2

[0146] Embodiment 2: tablet preparation

[0147] Weigh 100g of forsythiaside Ⅰ, add 100g of microcrystalline cellulose, 200g of lactose, mix well, add croscarmellose sodium, mix well, granulate with 24 mesh sieve, dry at 70°C, granulate, Add 1% magnesium stearate, mix well, and compress to make 1000 tablets.

Embodiment 3

[0148] Embodiment 3: capsule preparation

[0149] Weigh 100g of forsythiaside Ⅰ, add 50g of microcrystalline cellulose, add 10g of crospovidone, 130g of lactose, mix well, add 30ml of 5% povidone K30 aqueous solution, add 15ml of water, stir well, mix well, Granulate with a 24-mesh sieve, dry at 70°C, granulate, add 1% magnesium stearate, mix well, and pack into capsules to obtain 1000 capsules.

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Abstract

The invention discloses application of forsythiaside I in preparation of drugs for inhibiting respiratory syncytial viruses, and belongs to the field of application of plant extracts. An experiment proves that the forsythiaside I can effectively inhibit the respiratory syncytial viruses.

Description

technical field [0001] The invention belongs to the field of medicine application, and in particular relates to the application and preparation of plant extracts. Background technique [0002] Forsythiaside is an active ingredient extracted from Forsythia genus Forsythia in Oleaceae. Forsythiaside has pharmacological effects such as antimicrobial, antiviral, and antioxidative. Previous studies have found that almost all of forsythiaside is responsible for forsythiaside A, but it is difficult for forsythiaside A to exist stably alone, so it is customary to use forsythiaside A containing forsythiaside The active ingredient is called forsythiaside. The molecular formula of forsythiaside A is C 29 h 36 o 15 , the structural formula is as follows: [0003] . [0004] Forsythiaside I is a brown amorphous powder, high-resolution mass spectrometry shows that the molecular formula of forsythiaside I is C 29 h 36 o 15 , has the same molecular formula as forsythiaside A, and...

Claims

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Application Information

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IPC IPC(8): A61K31/7032C07H15/18C07H1/08A61P31/12A61P31/16A61P31/22
Inventor 王曙宾刘素娟王宏涛赵韶华孟学强
Owner SHIJIAZHUANG YILING PHARMA
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