Imaging agent, preparation method and application

An imaging agent and nanoparticle technology, which is applied in echo/ultrasound imaging agents, pharmaceutical formulations, preparations for in vivo tests, etc., can solve the problems of application limitations, inability to achieve two contrast effects at the same time, and inability to exist stably for a long time
CN105327367AActive Publication Date: 2016-02-17THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2016-02-17

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Abstract

The invention relates to an imaging agent. The imaging agent is characterized by comprising IR820-CSQ-Fe nanoparticles, wherein the IR820-CSQ-Fe nanoparticles comprises Fe3O4 coated with an A-X-B structure, wherein A is chitosan quaternary ammonium salt CSQadopting a structure shown as a formula (I), and n is an integer ranging from 17 to 290; B is new indocyanine green IR820 adopting a structure shown as a formula (II); X is a compound adopting a structure shown as a formula (III), and R is an alkylene group. The imaging agent has the advantages of superparamagnetism, outstanding T1 and T2 relaxation enhancement effect, photoacoustic imaging capacity, obvious fluorescence spectra, small and uniform particle size, good penetrability, avoidance of obvious cytotoxicity, good biocompatibility and better long circulation effect; a preparation method is simple, mild in condition and lower in cost; the imaging agent can be freeze-dried and stored for a long time in a solid form.
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Description

technical field

[0001] The invention belongs to the field of nano-imaging agents, in particular to a multi-mode imaging agent and its preparation method and application, especially to an imaging agent capable of T1 and T2 relaxation enhancement, fluorescence imaging or photoacoustic imaging for MRI imaging. In particular, it relates to an imaging agent that can be used as a tumor-targeted T1-T2 dual-nuclear magnetic resonance imaging contrast agent. Background technique

[0002] At present, for major diseases, it is very limited to use only one imaging method to determine the lesion location or lesion degree, and it has become a development trend to be able to image jointly by multiple methods.

[0003] The sensitivity of fluorescence imaging is particularly high, but the tissue penetration ability is relatively poor; the sensitivity of photoacoustic imaging is also high, and the penetration ability is strong, but due to the limited penetration ability of laser light, there ...

Claims

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