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Hollow capsule containing SiO2 and preparation method therefor

A hollow capsule and nanotechnology, which is used in capsule delivery, medical preparations with inactive ingredients, pharmaceutical formulations, etc., can solve the problems of reducing the dissolution rate in vitro, the migration of capsule substances, and accelerating the change of gelatin, so as to improve the anti-ultraviolet and anti-discoloration. , Long storage period, excellent gel performance

Inactive Publication Date: 2016-03-23
GUANGDONG GUOFANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing capsules use gelatin as the capsule material and glycerin as the plasticizer. Due to the properties of gelatin itself and the high permeability of glycerin, the capsules also have some stability problems, such as disintegration during storage. Phenomena such as substance migration occur, making formulation development difficult
[0004] Studies have found that strong ultraviolet or visible light irradiation will accelerate the change of gelatin, resulting in a decrease in the dissolution rate in vitro, such as high humidity while the light is on, and the gelatin capsule contains a red dye, the effect is particularly significant
Many dyes can combine with gelatin through hydrophobic bonds and hydrogen bonds, so the existing capsules are best stored in dark conditions, and their anti-tarnish performance is poor
In addition, traditional capsules have low strength and are prone to discoloration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A kind of nano-SiO containing 2 empty capsules, consisting of the following raw materials in parts by weight:

[0055] Main ingredients: 45 parts, plasticizer: 2 parts, Tween-20: 2 parts, titanium dioxide: 15 parts, pigment: 3 parts, nano-SiO 2 : 2-parts, water: 30 parts.

[0056] Wherein, the main ingredient is gelatin; the content of imino acid in the gelatin is 15% of the total mass of gelatin.

[0057] Wherein, the plasticizer is glycerin.

[0058] The nano-SiO 2 The particle size is 50nm.

[0059] The pigment is brilliant blue.

[0060] A kind of nano-SiO containing 2 The preparation method of the hollow capsule, comprises the following steps:

[0061] (1) Weighing: Weigh the main ingredients, plasticizer, Tween-20, titanium dioxide, pigment, nano-SiO 2 , water backup;

[0062] (2) Preparation of nanomaterial dispersion: plasticizer, Tween-20, nano-SiO 2 And water, dispersed into a nanomaterial dispersion by ultrasonic waves, the vibration frequency of ul...

Embodiment 2

[0066] A kind of nano-SiO containing 2 empty capsules, consisting of the following raw materials in parts by weight:

[0067] Main ingredients: 50 parts, plasticizer: 3 parts, Tween-40: 3 parts, titanium dioxide: 18 parts, pigment: 4 parts, nano-SiO 2 : 3 parts, water: 32 parts.

[0068] Wherein, the main ingredient is hydroxypropyl methylcellulose; the methoxyl content in the hydroxypropylmethylcellulose is 23%, the hydroxypropyl content is 10%, and the mass concentration at 20°C is The viscosity in 2% aqueous solution is 18mPa.s.

[0069] Wherein, the plasticizer polyethylene glycol. The polyethylene glycol is a mixture of PEG400 and PEG4000 in a mass ratio of 3:1.

[0070] The nano-SiO 2 The particle size is 60nm.

[0071] The pigment is lemon yellow.

[0072] A kind of nano-SiO containing 2 The preparation method of the hollow capsule, comprises the following steps:

[0073] (1) Weighing: Weigh the main ingredients, plasticizer, Tween-40, titanium dioxide, pigment...

Embodiment 3

[0078] A kind of nano-SiO containing 2 empty capsules, consisting of the following raw materials in parts by weight:

[0079] Main ingredients: 55 parts, plasticizer: 5 parts, Tween-80: 5 parts, titanium dioxide: 20 parts, pigment: 5 parts, nano-SiO 2 : 5 parts, water: 35 parts.

[0080] Wherein, the main ingredient is a mixture of gelatin and hydroxypropyl methylcellulose in a mass ratio of 2:1;

[0081] The content of imino acid in the gelatin is 12% of the total mass of gelatin.

[0082] The methoxyl content in the hydroxypropyl methylcellulose is 20%, the hydroxypropyl content is 12%, and the viscosity in an aqueous solution with a mass concentration of 2% at 20° C. is 15 mPa.s.

[0083] Wherein, the plasticizer is polyethylene glycol. The polyethylene glycol is a mixture of PEG400 and PEG4000 in a mass ratio of 4:1.5.

[0084] The nano-SiO 2 The particle size is 75nm.

[0085] The pigment is iron oxide.

[0086] A kind of nano-SiO containing 2 The preparation met...

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Abstract

The invention relates to the hollow capsule technology field, and concretely relates to a hollow capsule containing SiO2 and a preparation method therefor. The hollow capsule is composed of the following raw materials, by weight, 45-60 parts of main material, 2-10 parts of plasticizer, 2-10 parts of Tween, 15-25 parts of titanium dioxide, 3-8 parts of pigment, 2-10 parts of nano SiO2 and 30-40 parts of water. The main material is one or two of gelatin and hydroxypropyl methyl cellulose. The plasticizer is one or two of glycerin and polyethylene glycol. The preparation method for the hollow capsule has a simple technology, the hollow capsule moisture content is controlled between 10% and 20%, the prepared hollow capsule has good ultraviolet shield anti-tarnishing performance, has high tensile strength, and is not easy to change color.

Description

technical field [0001] The invention relates to the technical field of hollow capsules, in particular to a nano-SiO 2 Hollow capsules and preparation method thereof. Background technique [0002] In the prior art, compared with other dosage forms, capsules have the characteristics of high bioavailability, good sealing, good drug stability, accurate content, beautiful appearance, etc., which can increase stability, improve bioavailability and taste masking. effect. [0003] Most of the existing capsules use gelatin as the capsule material and glycerin as the plasticizer. Due to the properties of gelatin itself and the high permeability of glycerin, the capsules also have some stability problems, such as disintegration during storage. Phenomena such as substance migration occur, making preparation development difficult. [0004] Studies have found that strong ultraviolet or visible light irradiation will accelerate the change of gelatin, resulting in a decrease in the disso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/02A61K47/14A61K47/38A61K47/34A61K47/42A61K47/10
CPCA61K9/48A61K47/02A61K47/14A61K47/34A61K47/38A61K47/42A61K9/4816A61K9/4825
Inventor 刘瑞驹张玉宜杨洋袁康亮
Owner GUANGDONG GUOFANG MEDICAL TECH
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