Traditional Chinese medicine composition for treating chronic and acute liver failure enterogenic endotoxemia and enema

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic and acute liver failure enterogenic endotoxemia. The composition is prepared from, by weight, 20-23 parts of rhubarb, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of fructus aurantii immaturus, 20-40 parts of red peony roots, 10-20 parts of fructus mume, 20-40 parts of dandelions and 10-15 parts of coptidis rhizomes. The traditional Chinese medicine composition can be prepared into an enema through the method including the steps that all the raw materials are evenly mixed, water is added and gets over the medicine surface, the materials are soaked for 20-40 min and decocted for two to five times, decoction solutions obtained each time are combined, and the enema is obtained. The traditional Chinese medicine enema can be used for treating enterogenic endotoxemia, protecting intestinal mucosa, improving intestinal flora and facilitating disease recovery, the length of stay can be shortened, and medical cost is reduced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition and an enema for treating acute-on-chronic liver failure enterogenous endotoxemia. Background technique [0002] Acute-on-chronic liver failure is a short-term clinical syndrome of acute or subacute liver function decompensation on the basis of chronic liver disease, manifested as extreme fatigue, obvious gastrointestinal symptoms, rapidly deepening jaundice, obvious bleeding tendency, ascites, etc. Its condition is critical and the mortality rate is high. Regarding the pathogenesis of liver failure, some scholars have put forward the triple-hit hypothesis in recent years, that is, liver failure caused by HBV undergoes a triple fatal blow of immune injury, ischemia-hypoxic injury, and endotoxemia in sequence. Intestinal endotoxemia and liver damage are mutually causal, and play a key role in the occurrence and de...

AI Technical Summary

Problems solved by technology

[0005] 1. Polymyxin b is considered to be the only antibiotic with anti-endotoxin effect, but it is limited to severe adverse reactions that damage the kidney and cannot be directly applied to anti-endotoxin treatment in vivo; in recent years, the hinges produced by drug hinge technology are mostly The effectiveness of the myxomycin b complex and the stability of the polymyxin b hinge need to be further verified, and this new technology for applying polymyxin b is still in the stage of experimental exploration;

[0006] 2. Blood purification technology: It is a pioneering work to apply blood purification technology to the treatment of endotoxemia. However, because endotoxin is a high-molecular substance, hemodialysis alone cannot effectively remove endotoxin. Plasma proteins, especially albumin, have a high affinity with lipopolysaccharide, which can partially remove the free endotoxin in the patient's plasma. However, this technology consumes a lot of materials, is expensive, and the curative effect is not ideal. The ratio of effect to cost is very low. Low, difficult to promote;

[0007] 3. Anti-lipopolysaccharide and anti-inflammatory mediators: monoclonal antibody preparations including E5 and HA-1A are considered to bring new hope to the treatment of endotoxemia, and the short-term efficacy of clinical trial treatment has achieved initial results. It is considered to be the most promising treatment method, but more and more clinical trials report that the long-term efficacy and safety of anti-lipopolysaccharide antibodies need further observation and evaluation

[0013] The above-mentioned technical scheme is a beneficial attempt to treat endotoxemia with traditional Chinese medicine, but there are also flaws. Only using the active ingredients of traditional Chinese medicine to treat endotoxemia is contrary to the compatibility principle of traditional Chinese medicine. Each Chinese medicine contains a variety of For chemical components, it is biased to extract the main components alone to treat diseases, which can not only cause a waste of traditional Chinese medicine resources, but also lose active ingredients, because the combination of traditional Chinese medicines requires complex chemical reactions to improve the curative effect.

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