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Cataplasm and method for producing same

A manufacturing method and peg technology, which are applied in the field of peg and its manufacture, can solve problems such as decreased adhesion and inhibit the decline of adhesion, and achieve the effect of sufficient adhesion and maintenance of adhesion

Active Publication Date: 2016-04-06
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the adhesive power of poultice tends to decrease with time after application. For example, in the following patent documents 1 and 2, the problem of suppressing the decrease in adhesive force has been studied.

Method used

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  • Cataplasm and method for producing same
  • Cataplasm and method for producing same
  • Cataplasm and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0075] Hereinafter, the poultry of the present invention will be described in detail using examples and test examples, but the present invention is not limited by the examples. In addition, unless otherwise specified, the content described in Tables 1-12 shows mass %. The preparation method of the poultry and the measurement method of the adhesive force in the Examples and Test Examples are as follows.

[0076] (Poultry preparation method)

[0077] Stir and mix the necessary ingredients for the prescribed time to obtain a paste. The obtained paste was evenly spread on the release liner so that the paste mass per sheet of poultice (140 mm×100 mm) was 5 g, and immediately thereafter, a nonwoven fabric was further laminated to prepare a poultice.

Embodiment 1

[0096] Time-dependent changes in the adhesive force of a cement compound containing a completely neutralized polyacrylic acid and a methyl acrylate-2-ethylhexyl acrylate copolymer emulsion

[0097] (1) Test sample

[0098] Using fully neutralized polyacrylic acid (trade name: VISCOMATEF480SS, manufactured by Showa Denko Co., Ltd.) instead of partially neutralized polyacrylic acid, mix 16.7% by mass of methyl acrylate·2-ethylhexyl acrylate copolymer resin emulsion (trade name: NIKASOLTS-620 (manufactured by Nippon Carbide Industries Co., Ltd.), 30% by mass of concentrated glycerin, and 37.8% by mass of purified water were followed in the same manner as in Comparative Example 1 to prepare a poultice (Example 1).

[0099] (2) Test method

[0100] The test was performed by the same method as [Comparative Example 1].

[0101] (3) Test results

[0102] Such as figure 2 As shown, the adhesion score of Comparative Example 2 was 90 immediately after application, and the adhesion s...

Embodiment 2

[0104] Time-dependent changes in the adhesive force of a poultry compounded with partially neutralized polyacrylic acid and methyl acrylate-2-ethylhexyl acrylate copolymer emulsion

[0105] (1) Test sample

[0106] Mix 16.7% by mass of methyl acrylate·2-ethylhexyl acrylate copolymer (trade name: NIKASOLTS-620, manufactured by Nippon Carbide Industry Co., Ltd.), 30% by mass of concentrated glycerin, and 37.8% by mass of purified water. Otherwise, it carried out similarly to the comparative example 1, and obtained the poultice (Example 2).

[0107] (2) Test method

[0108] The test was performed by the same method as [Comparative Example 1].

[0109] (3) Test results

[0110] Such as image 3 As shown, the adhesion score of Example 1 was 100 immediately after application, and the adhesion score decreased by about 9% after 12 hours from application. The adhesion score of Example 1 did not decrease from 4 hours to 12 hours after attachment.

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Abstract

The invention provides a cataplasm which comprises a plaster layer on a supporting body. The plaster layer is obtained by mixing at least a neutralized polyacrylic acid, a poly(methyl acrylate / 2-ethylhexyl acrylate) emulsion in an amount of 2.5 times or more, preferably 3 times or more the amount of the neutralized polyacrylic acid on a mass basis, and water. The poly(methyl acrylate / 2-ethylhexyl acrylate) emulsion has an evaporation residue of 57-61% when heated at a temperature not lower than the boiling point of the medium.

Description

technical field [0001] The present invention relates to poultice and its manufacturing method. Background technique [0002] Poultry is a type of patch prepared by coating a paste containing a drug on a support such as cloth. Generally, it is characterized by containing a large amount of water, having a thick paste, and being less irritating to the skin. However, poultice tends to decrease in adhesion over time after application. For example, in Patent Documents 1 and 2 below, the problem of suppressing the decrease in adhesion has been studied. [0003] prior art literature [0004] patent documents [0005] Patent Document 1: Japanese Patent Application Laid-Open No. 9-208462 [0006] Patent Document 2: International Publication No. 2006 / 090782 Contents of the invention [0007] The problem to be solved by the invention [0008] However, with the poultices described in Patent Documents 1 and 2, the adhesive force of the poultry may be insufficient when the thickness...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/34
CPCA61L15/225A61L15/585A61L15/60C08L71/00C08F220/14C08L33/02A61K9/7061C08L33/08C08F220/1808A61K9/703A61K47/32A61K47/34A61K47/38A61K47/42
Inventor 鹤岛圭一郎古濑靖久水流诚一郎山外真嗣义永隆明
Owner HISAMITSU PHARM CO INC
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