Vitamin E acetate-coated nanometer solid lipid carrier and preparation method thereof

A solid lipid and vitamin technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as low permeability, poor dispersion performance, instability, etc., to promote penetration and utilization High efficiency and improved stability

Inactive Publication Date: 2016-04-20
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the invention is in order to solve above-mentioned Vitamin E acetate is unstable, poor in dispersion and low in permeability when used in cosmetics and other technical issues, while providing a Using phospholipids as one of the lipid raw materials, the nano-solid lipid carrier coated with vitamin E acetate makes vitamin E acetate stable, good dispersion performance in water medium, and high permeability

Method used

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  • Vitamin E acetate-coated nanometer solid lipid carrier and preparation method thereof
  • Vitamin E acetate-coated nanometer solid lipid carrier and preparation method thereof
  • Vitamin E acetate-coated nanometer solid lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A nano solid lipid carrier coated with vitamin E acetate, calculated according to the total amount of 100g, its composition and content are as follows:

[0065]

[0066] The phospholipid is soybean lecithin with a PC content of 50%, Beijing Meas Phospholipid Technology

[0067] Food grade products produced by limited company;

[0068] Described solid emulsifier is Gemini emulsifier;

[0069] Described solid lipid is hydrogenated castor oil;

[0070] Described liquid lipid is jojoba oil;

[0071] Described polyhydric alcohol is glycerol;

[0072] Described preservative is dehydroacetic acid;

[0073] The above-mentioned nanometer solid lipid carrier coated with vitamin E acetate is characterized in that it specifically comprises the following steps:

[0074] (1), preparation of oil phase system

[0075] Add vitamin E acetate, phospholipids, solid lipids, liquid lipids, and solid emulsifiers into the container, control the temperature to melt at 70-95°C, and disp...

Embodiment 2

[0085] A nano solid lipid carrier coated with vitamin E acetate, calculated according to the total amount of 100g, its composition and content are as follows:

[0086]

[0087] The phospholipid is egg yolk lecithin with a PC content of 70%, a food-grade product produced by Beijing Meas Phospholipid Technology Co., Ltd.;

[0088] Described solid emulsifier is sodium stearoyl glutamate;

[0089] The solid lipid is cetearyl octanoate;

[0090] The liquid lipid is isotridecanyl isononanoate;

[0091] Described polyhydric alcohol is propylene glycol;

[0092] Described preservative is sorbic acid.

[0093] The preparation method of the above-mentioned nano solid lipid carrier coated with vitamin E acetate is the same as in Example 1.

Embodiment 3

[0095] A nano-solid lipid carrier coated with vitamin E acetate, that is, a phospholipid-containing nano-solid lipid carrier coated with vitamin E acetate, calculated according to the total amount of 100g, its composition and content are as follows:

[0096]

[0097]

[0098] The phospholipid is soybean lecithin with a PC content of 70%, a food-grade product produced by Shanxi Senfu Natural Products Co., Ltd.;

[0099] Described solid emulsifier is cetearyl glucoside;

[0100] The solid lipid is behenyl alcohol;

[0101] Described liquid lipid is isopropyl palmitate;

[0102] Described polyhydric alcohol is 1,3-butanediol;

[0103] The preservative is propylene glycol-bis-imidazolidinyl urea.

[0104] The preparation method of the above-mentioned nano solid lipid carrier coated with vitamin E acetate, that is, the phospholipid-coated nano solid lipid carrier of vitamin E acetate is the same as that in Example 1.

[0105] Use the Quanta200F scanning electron microscop...

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Abstract

The invention provides a vitamin E acetate-coated nanometer solid lipid carrier and a preparation method thereof. The vitamin E acetate-coated nanometer solid lipid carrier is prepared from the following raw materials in percentage by weight: 3%-20% of vitamin E acetate, 0.5%-5% of phospholipid, 3%-20% of a solid emulsifier, 2%-15% of solid lipid, 2%-10% of liquid lipid, 5%-20% of polyhydric alcohol, 0.01%-0.8% of a preservative and the balance of deionized water. The preparation method comprises the following steps: melting the vitamin E acetate, the phospholipid, the solid emulsifier, the solid lipid and the liquid lipid to obtain an oil phase; mixing the polyhydric alcohol with the deionized water to obtain a water phase; when temperatures of the two phases are heated to 70-95 DEG C respectively, adding the oil phase in the water phase stirring process, homogenizing the oil phase to obtain an emulsified system, and then carrying out high-pressure homogenization; and finally cooling the emulsified system while stirring, when the temperature is reduced to 40-60 DEG C, adding the preservative, and stirring and cooling to a room temperature, so as to obtain the vitamin E acetate-coated nanometer solid lipid carrier.

Description

technical field [0001] The invention relates to a nano solid lipid carrier coated with vitamin E acetate and a preparation method thereof, belonging to the field of chemical industry. Background technique [0002] Natural functional ingredient Vitamin E acetate is an antioxidant, a light yellow oily liquid, soluble in alcohol, ether and other organic solvents, almost insoluble in water, and easily oxidized. VE acetate is used in cosmetics, not only has a moisturizing effect, but also can maintain skin moisture, and has a protective effect on cuts, burns, acne, age spots, frostbite, dry skin and ultraviolet damage, while reducing lipid peroxidation and smoothing Good effect on skin etc. Its effect mainly depends on the concentration and the permeability in the skin, but when it is used in ordinary cream emulsion, because it is easy to precipitate, the concentration should not be too high, and the particles are large, which will affect its penetration. [0003] Nano solid li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/67A61K8/55A61Q19/00
CPCA61K8/14A61K8/553A61K8/678A61K2800/10A61Q19/00
Inventor 张婉萍王轲梁小智朱海洋
Owner SHANGHAI INST OF TECH
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