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Preparing method of ambroxol salbutamol oral liquid

A technology of ambroxosalbutamol oral liquid and salbutamol sulfate, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as poor stability, unstable effect, and difficult quality control. problem, to achieve stable quality, remarkable effect, and the effect of treating respiratory diseases

Inactive Publication Date: 2016-04-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there are oral solutions containing ambroxol hydrochloride and salbutamol sulfate in the prior art, there are still problems such as poor stability, difficult quality control, and unstable effects.

Method used

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  • Preparing method of ambroxol salbutamol oral liquid
  • Preparing method of ambroxol salbutamol oral liquid
  • Preparing method of ambroxol salbutamol oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh each component according to the following proportions: 2 g of ambroxol hydrochloride, 2 g of salbutamol sulfate, 3 g of propylene glycol, 0.5 g of glycerin, 0.2 g of methyl p-hydroxybenzoate, 0.3 g of sodium benzoate, 1 g of mannitol, 2 g of stevia, orange Essence 0.5g, appropriate amount of pH regulator, appropriate amount of purified water; take about 2 / 3 of purified water, add ambroxol hydrochloride, stir to dissolve completely, add salbutamol sulfate, propylene glycol, glycerin, methyl p-hydroxybenzoate, benzene Sodium formate, mannitol, stevioside and orange essence, stir evenly, adjust the pH value to about 4.0 with a pH regulator, add purified water to the full amount, filter with a 0.45μm microporous membrane, fill into an oral liquid bottle, seal, After passing the inspection, it is packaged and ready to be obtained.

Embodiment 2

[0019] Each component was weighed according to the following ratio: 5g of ambroxol hydrochloride, 3.6g of salbutamol sulfate, 2.5g of propylene glycol, 1g of glycerin, 0.3g of methyl p-hydroxybenzoate, 0.2g of sodium benzoate, 2g of mannitol, 3g of stevia, Orange flavor 0.2g, appropriate amount of pH regulator, appropriate amount of purified water; take about 2 / 3 of purified water, add ambroxol hydrochloride, stir to dissolve completely, add salbutamol sulfate, propylene glycol, glycerin, methyl p-hydroxybenzoate, Sodium benzoate, mannitol, stevia and orange flavor, stir well, adjust the pH value to about 4.5 with a pH regulator, add purified water to the full amount, filter with a 0.45μm microporous membrane, fill it into an oral liquid bottle, and seal it , passed the inspection, packaged, and obtained.

Embodiment 3

[0021] Weigh each component according to the following ratio: Ambroxol hydrochloride 7g, salbutamol sulfate 2g, propylene glycol 4g, glycerin 2g, methyl p-hydroxybenzoate 0.4g, sodium benzoate 0.1g, mannitol 3g, stevia 5g, orange essence 0.3g, appropriate amount of pH regulator, appropriate amount of purified water; take about 2 / 3 of purified water, add ambroxol hydrochloride, stir to dissolve completely, add salbutamol sulfate, propylene glycol, glycerin, methyl p-hydroxybenzoate, sodium benzoate , mannitol, stevia and orange essence, stir well, adjust the pH value to about 6 with a pH regulator, add purified water to the full amount, filter with a 0.45μm microporous membrane, fill it into an oral liquid bottle, seal it, and inspect Qualified, packed, ready to go.

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Abstract

The invention relates to an ambroxol salbutamol oral liquid and a preparing method thereof, belonging to the field of medicinal preparations. The oral liquid contains components such as ambroxol hydrochloride, salbutamol sulfate, propylene glycol, glycerol, methyl parahydroxybenzoats, sodium benzoate, mannitol, Steviosin and flavoring orange essence, is stable in quality, obvious in effect and capable of effectively treating diseases of the respiratory system such as acute and chronic bronchitis and asthma.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an ambroxoxalbutamol oral liquid and a preparation method thereof. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease. The main lesions are in the trachea, bronchi, lungs, and chest cavity. Mild cases often cause coughing, chest pain, and respiratory problems. Severe cases have dyspnea, hypoxia, and even death due to respiratory failure. The death rate in the city is the third, while in the countryside it is the first. What should be paid more attention to is that due to air pollution, smoking, population aging and other factors, chronic obstructive pulmonary disease (referred to as COPD, including chronic bronchitis, emphysema, pulmonary heart disease), bronchial asthma, lung cancer, etc. , Pulmonary diffuse interstitial fibrosis, and the morbidity and mortality of diseases such as pulmonary infection are increasing. ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/08A61K47/26A61P11/00A61P11/06
CPCA61K9/0095A61K31/137A61K47/10A61K47/12A61K47/26A61K2300/00
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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