Manufacture device and method for hemostatic gauze product with high stability and absorbability

Abstract

The invention discloses a manufacture device and method for a hemostatic gauze product with high stability and absorbability. The device comprises a tank body, a tank cover matched with the tank body, a stainless steel plate in the tank body, an ultrasonic generator at the bottom of the tank body, a feed pipe and a liquid discharge port, wherein an air inlet and an air outlet are formed in the tank cover, and the feed pipe, the air inlet, the air outlet and the liquid discharge port are each provided with a valve. The manufacture device for the hemostatic gauze product with high stability and absorbability is designed according to the requirements for cellulose pretreatment, oxidation, cleaning and aftertreatment and is convenient to operate.

Description

technical field [0001] The invention relates to the field of cellulose hemostatic products, in particular to a preparation device and method for a highly stable and highly absorbable hemostatic gauze product. Background technique [0002] Oxidized cellulose and oxidized regenerated cellulose, due to their good biocompatibility and degradability, can be used as hemostatic gauze products in the medical field. At present, the product with the widest range of clinical application is the product of American Johnson & Johnson—the medical absorbable hemostatic gauze "Surgical". Suji Yarn has a relatively large specific surface area, high cost, and slow hemostasis. It takes 2-8 minutes to achieve hemostasis. It is more suitable for wounds with small bleeding volume, but it cannot be quickly and effectively absorbed in parts with severe bleeding. The existing form of the product It is not conducive to the combination with other products, and it is urgent to develop new substitute pr...

AI Technical Summary

Problems solved by technology

[0006] 2. In the oxidation reaction system, the reaction process control is not strict

Experiments have shown that in nitrogen oxide oxidation systems, if the reaction system contains water and oxygen, more side reactions will occur, including non-selective oxidation, resulting in more severe oxidative degradation of cellulose macromolecular chains, which makes the oxidized fiber The strength of plain gauze decreases rapidly

[0007] 3. During the oxidation reaction process, the reaction system mentioned in the report is basically in a static reaction state, lacking sufficient mass transfer power, which makes the reaction time very long, and leads to severe degradation of oxidized cellulose, and it is difficult to stably control the degree of oxidation

[0008] On the one hand, because the reaction system is in a static state, and the cellulose hemostatic gauze fabric is immersed in it, the concentration in this type of oxidation reaction is not uniform, and the oxidation reaction is therefore also in a state of inhomogeneity.

Moreover, the by-products generated in the oxidation reaction cannot be removed from the cellulose fabric fibers in time, which will lead to more side reactions, especially non-selective oxidation reactions.

On the other hand, since the reaction is in a static state, the reaction time takes a long time, but the long-term oxidation reaction makes the reaction solvent continue to undergo oxidation reaction, and the produced carboxylic acid substances are attached to the cellulose fabric, further causing the fiber The rapid degradation of the macromolecular chain of the protein also leads to the uneven distribution of the carboxyl content during the oxidation process.

These problems make the performance of the oxidized product decrease, the storage stability is not enough, and the absorbability is poor

[0009] 4. The post-processing means of the product are unreasonable

Our experiments show that these post-treatments can greatly reduce the storage stability of oxidized fiber products

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