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Method for producing sterilized medical molded body

A manufacturing method and molding technology, which can be applied in the directions of disinfection and irradiation, and can solve the problems of not recording the types and amounts of antioxidants.

Active Publication Date: 2016-04-20
ZEON CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, this document only describes that as antioxidants to be blended, phosphorus antioxidants, phenolic antioxidants, sulfur antioxidants, etc. are listed in order to prevent oxidative deterioration when molded into containers, and it is more preferable to color them. There are few phosphorus antioxidants, but there is no record about the type and amount of antioxidants that are beneficial for electron beam sterilization and gamma ray sterilization

Method used

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  • Method for producing sterilized medical molded body
  • Method for producing sterilized medical molded body

Examples

Experimental program
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Embodiment

[0081] Hereinafter, the present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to these examples. In the following examples and comparative examples, parts and % are based on weight unless otherwise specified.

[0082] The measurement methods of various physical properties are shown below.

[0083] (1) Weight average molecular weight (Mw) and molecular weight distribution (Mw / Mn)

[0084] The molecular weight of the block copolymer and the hydrogenated product of the block copolymer was measured at 38°C as a value in terms of standard polystyrene by gel permeation chromatography (GPC) using THF as an eluent. As a measuring device, HLC8020GPC manufactured by Tosoh Corporation was used.

[0085] (2) Hydrogenation rate

[0086] The hydrogenation rate of the hydrogenated block copolymer is the proportion of hydrogenated carbon-carbon bonds relative to the total amount of carbon-carbon unsa...

reference example 1

[0101] Synthesis of Resin Composition [2]-1 Consisting of Hydrogenated Block Copolymer and Antioxidant

[0102] 550 parts of dehydrated cyclohexane, 25.0 parts of dehydrated styrene, and 0.475 parts of di-n-butyl ether were charged into a reactor equipped with a stirring device whose interior was sufficiently replaced with nitrogen. While stirring the entire contents at 60°C, 0.67 parts of n-butyllithium (15% cyclohexane solution) was added to initiate polymerization, and the reaction was further carried out for 60 minutes while stirring at 60°C. As a result of measuring the reaction solution by gas chromatography, the polymerization conversion rate at this point was 99.5%.

[0103] Then, 50.0 parts of dehydrated isoprene was added to the reaction liquid, and stirring was continued at 60° C. for 30 minutes while maintaining the state. As a result of measuring the reaction solution by gas chromatography, the polymerization conversion rate was 99% at this point.

[0104] Then,...

reference example 2

[0112] Synthesis of Resin Composition [2]-2 Consisting of Hydrogenated Block Copolymer and Antioxidant

[0113] Except for using 3.5 parts of the hydrogenation catalyst, pellets 94 of a resin composition ([2]-2) composed of a hydrogenated block copolymer ([1]-2) and an antioxidant were obtained in the same manner as in Reference Example 1. share.

[0114]The hydrogenated block copolymer of the obtained resin composition ([2]-2) had a weight average molecular weight (Mw) of 65,100, a molecular weight distribution (Mw / Mn) of 1.11, a hydrogenation rate of 99.6%, and wA:wB=50: 50. The amount of the antioxidant is 0.05 parts by weight relative to 100 parts by weight of the hydrogenated block copolymer ([1]-2). These data are described in Table 1.

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Abstract

A method for producing a sterilized medical molded body by high energy irradiation of the medical molded body with an exposure dose E, the medical molded body being formed from a resin composition comprising: 100 parts by weight of a block copolymer hydride in which 99% or more of the total unsaturated bond of a block copolymer is hydrogenated, the block copolymer comprising a polymer block (A) that is composed mainly of a unit derived from an aromatic vinyl compound and a polymer block (B) that is composed mainly of a unit derived from a chain conjugated diene compound with a ratio of the weight fraction of the polymer block (A) and the polymer block (B) being 30:70 to 70:30; and a phenolic antioxidant in an amount of parts by weight represented by formula 1: W=[0.46x(100-H)+0.04]x(E / 25) (In the formula, W is the parts by weight of the antioxidant with respect to 100 parts by weight of the block copolymer hydride, H is a hydrogenation degree of the block copolymer hydride indicated in % units, H is a numerical value of 99 to 100, and E is an exposure dose of high energy rays indicated in kGy units) or more and 0.50 parts by weight or less.

Description

technical field [0001] The present invention relates to a method for producing a sterilized molded body for medical use. The method includes sterilizing the molded body for medical use by irradiating high-energy rays. A resin composition containing a phenolic antioxidant in a specific ratio. Background technique [0002] Sterilization treatment based on high-energy ray irradiation is commonly used as a simple and reliable sterilization method because it can sterilize molded articles for medical use in the state of packaging them into cartons, plastic boxes, etc. for transportation, for example. . [0003] Hydrogenated block copolymers are known to be suitable for medical moldings such as vials, infusion bags, syringes, and culture containers because they are excellent in transparency, heat resistance, and flexibility, and can be steam sterilized (patent Documents 1-4). [0004] It is also known to mix antioxidants such as phenolic antioxidants, phosphorus antioxidants, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/00A61L2/08C08K5/13C08L53/02
CPCC08K5/13C08L53/025A61L2/081A61L2/087
Inventor 小原祯二石黑淳
Owner ZEON CORP
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