An optically-controlled tea sapogenin nanometer preparation, a preparing method thereof and uses of the nanometer preparation
A technology of tea saponin and nano-preparation, which is applied in the field of medicine to achieve the effect of simple preparation process and stable structure
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Embodiment 1
[0034] Get tea saponin 100g, dissolve it with 100g n-butanol, add 0.5g Tween 60 and 1000g water, stir at 200 rpm for 2 hours, and make a cystic heart solution; take lecithin-cholesterol compound (lecithin- Cholesterol mass ratio 3:1) 100g, use ethanol to make a capsule material solution with a mass concentration of 1%, add 0.1g pheophorbide and 0.5g Span 60, and stir at 200 rpm for 2 hours to make a mixture solution; Add the capsule core solution dropwise to the mixture solution at a speed of 80 drops / min, and stir at 5000 rpm for 0.5 hour; pass through a 0.5 μm microporous membrane, and distill the filtrate to ethanol under reduced pressure at 60°C and 0.01 atmosphere for 1 hour, 310 g of light-controlled theasapogenin nano-preparation was prepared.
Embodiment 2
[0036] Take 100g of tea saponin, dissolve it with 100g of dimethyl sulfoxide, add 1g of polyoxyethylene stearate and 500g of water, and stir at 500 rpm for 1 hour to make a cystic heart solution; take another lecithin-cholesterol compound (lecithin-cholesterol mass ratio 2:1) 300g, make a capsule material solution with a mass concentration of 5% with acetone, add 1.5g hypocretin A and 3g glyceryl monostearate, and stir at 500 rpm After 1 hour, the mixture solution was prepared; the capsule core solution was added dropwise to the mixture solution at a rate of 60 drops / min, and stirred at 2000 rpm for 1 hour; passed through a 0.4 μm microporous membrane, and the filtrate was kept at 40°C and 0.08 atmospheric pressure The acetone was distilled off under reduced pressure for 0.5 hour to obtain 530 g of light-controlled theasapogenin nano-preparation.
Embodiment 3
[0038] Get 100g of tea saponin, dissolve it with 100g of tetrahydrofuran, add 2g of sucrose fatty acid ester and 600g of water, stir at 800 rpm for 1.5 hours, and make a capsule core solution; get another 200g of polyglycolide PLGA50 (Aldrich), Dichloromethane was made into a capsule material solution with a mass concentration of 2%, added 2g curcumin and 6g monoglyceride laurate, and stirred at 800 rpm for 1.5 hours to make a mixture solution; the capsule core solution was dripped at a speed of 40 drops / minute Add it to the mixture solution, stir at 500 rpm for 2 hours; pass through a 0.3 μm microporous membrane, distill the filtrate out of dichloromethane under reduced pressure at 50°C and 0.03 atmospheric pressure for 1.5 hours, and obtain the light-controlling tea saponin nano-preparation 415g.
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