Anti-tumor drug compound, preparation method and application
A technology of anti-tumor drugs and compounds, applied in the field of energy metabolism that inhibits anaerobic glycolysis process, can solve the problem of limited tumor suppression
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Embodiment 1
[0029] Embodiment 1 (best synthesis example)
[0030] 2-Deoxyglucose (78mg, 0.48mmol): Metformin hydrochloride (80mg, 0.48mmol), dissolved in 20mL methanol, nitrogen gas for 0.5h, 40°C for 3h, naturally cooled to room temperature after the reaction, and distilled off the solvent under reduced pressure , recrystallized from ethanol-ether (v / v-1:1), and dried in vacuo to obtain 140 mg of the product.
[0031] Molecular formula C 10 h 23 N 5 o 5 Elemental analysis: C, 40.83; H, 7.85; N, 23.75%. Ultraviolet UV-vis (CH 3 OH / nm)(ε×10 -4 ,dm 3 mol -1 cm -1 ):232(3.4).Infrared Spectrum IR(KBr,ν / cm -1 ):3371m, 3160m, 2900-2995m, 1628s, 1556s, 1468s, 1078s, 1007s, 710m, .600cm -1.
Embodiment 2
[0033] 2-deoxyglucose (248mg, 1.44mmol): metformin hydrochloride (80mg, 0.48mmol), wherein the molar ratio of 2-deoxyglucose to metformin hydrochloride is 3:1, dissolved in 10mL of methanol (the amount of 2-deoxyglucose substance and methanol The volume ratio is 1.44mmol: 10ml), blow nitrogen for 0.5h, and react at 10°C for 1h. After drying, 40 mg of the product was obtained, indicating that the yield of this synthetic scheme was lower than that of the best practice case.
Embodiment 3
[0035] 2-deoxyglucose (78mg, 0.48mmol): metformin hydrochloride (254mg, 1.44mmol), wherein the molar ratio of 2-deoxyglucose to metformin hydrochloride is 1:3, dissolved in 40mL of methanol (the amount of 2-deoxyglucose substance and methanol The volume ratio is 0.48mmol: 40ml), blowing nitrogen for 0.5h, reacting at 80°C for 6h, naturally cooling to room temperature after the reaction, distilling off the solvent under reduced pressure, recrystallizing from ethanol-ether (v / v-1:1), After vacuum drying, 70 mg of the product was obtained, which indicated that the yield of this synthetic scheme was lower than that of the best implementation case.
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