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Paclitaxel crystal and preparation method of medicinal liquor and oral liquid of paclitaxel crystal

A paclitaxel oral liquid and a technology for paclitaxel, which are applied in the field of preparation of paclitaxel crystals, medicinal wine and oral liquid, can solve problems such as harm to toxic patients, and achieve the effects of good effect, good extraction effect and simple operation.

Inactive Publication Date: 2016-05-04
SHENZHEN ZHONGNONG KEGONG VENTURE ASSET MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Paclitaxel extracted from the bark and branches of Taxus chinensis is recognized as a natural compound with anti-cancer effects in the world. It is called by experts as the most valuable plant-derived anti-cancer drug in the 21st century. The application of yew has attracted more and more attention, but the production process of extracting paclitaxel from yew mostly uses CO 2 and ultrasonic extraction and other processes, the toxicity of the residual substances after some chemical solvents have caused new harm to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Remove impurities, O 3 Wash with water, remove the soil and other impurities attached to the surface of the whole yew plant dry product of 100kg, put into O 3 Wash in the water cleaning pool; (2) slice, take out the whole plant of yew after cleaning and drain the water, cut into thin slices with a thickness of 1-3mm, and the effect of 2mm is better; (3) dry, put the thin slices of yew Put it into a stainless steel tray, send it into a hot air circulation dryer at 50 degrees, and dry it for 3 hours, and take it out when the moisture content is below 5%; (4) crush, and the dried yew fragments are crushed by a stainless steel crusher, The particle size is less than 1mm; (5) ultra-micro-broken, 100kg of yew powder after crushing is ultra-finely pulverized to 300 mesh by a nano-ultra-micro-broken machine; (6) soaked in ethanol for peeling, using 95% medical ethanol 500kg, 100kg of yew whole plant superfine powder into a sealed stainless steel container, indirect heating...

Embodiment 2

[0031] A method for paclitaxel medicated wine, the preparation method of said medicated wine comprises the steps:

[0032] 5.1 The paclitaxel crystals were pulverized to 80 mesh to obtain the crude paclitaxel;

[0033] 5.2 Take 50 kg of oat wine at 38 degrees, put it into a container, heat it indirectly at 40 degrees, then put in 5 kg of paclitaxel crude product, stir, and after it is completely dissolved, filter it with a 0.1 μm filter membrane to obtain paclitaxel medicinal wine, and then measure and fill it, each bottle 250ml, a class of rheumatism patients, adopt this method to prepare paclitaxel medicinal wine, take 25ml every day, after 3 months, the symptoms are greatly relieved.

Embodiment 3

[0035] A preparation method of paclitaxel oral liquid, the preparation method of described paclitaxel oral liquid comprises the steps:

[0036] 6.1 The paclitaxel crystals were pulverized to 80 mesh to obtain the crude paclitaxel;

[0037] 6.2 Put 7500ml of distilled water into the container, heat it indirectly at 40 degrees, put in 500g of rock sugar, and 50 tablets of vitamin C. Propolis 45ml, fully stirred for 10 minutes, when all of it was released into a pink microemulsion, poured into a container containing 40kg propolis, stirred for 20 minutes, after miscible, metered and filled, each 10ml, to obtain paclitaxel oral liquid , Ms. Wang, whose physical condition is sub-healthy, has been suffering from insomnia, accelerated skin aging, and endocrine disorders. She insists on taking two bottles of this oral solution every day. After half a year, her insomnia troubles disappeared and her physical condition improved greatly.

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Abstract

The invention provides a paclitaxel crystal, relates to the technical field of Chinese medicinal health care, and provides non-toxic extracted paclitaxel. The non-toxic extracted paclitaxel is prepared by the steps of purifying, slicing, drying, smashing, ultrafine wall-breaking, ethanol soaking delamination, primary filtration, detoxifying, low-pressure macro-porous ultrafiltration, high-pressure micro-porous ultrafiltration, chromatography, vacuum permeation and concentration, secondary detoxification, and low-temperature vacuum drying. The prepared paclitaxel crystal has the beneficial effects of freeness from chemical agents and good extraction effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine health care, in particular to a preparation method of paclitaxel crystals, herbal wine and oral liquid. Background technique [0002] Paclitaxel extracted from the bark and branches of Taxus chinensis is recognized as a natural compound with anti-cancer effects in the world. It is called by experts as the most valuable plant-derived anti-cancer drug in the 21st century. The application of yew has attracted more and more attention, but the production process of extracting paclitaxel from yew mostly uses CO 2 And ultrasonic extraction and other processes, the existence of the toxicity of the residual substances after some chemical solvents have caused new harm to patients. At the same time, the quality of non-toxic extracted paclitaxel is better than the residual one, and its physiological activity is strong, especially the retention of small molecular compounds in taxus pigmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D305/14C12G3/04A61K31/337A61K35/644A61P39/06A61P25/20A61P5/00
CPCC07D305/14A61K9/0095A61K31/337A61K35/644A61K47/34C12G3/04A61K2300/00
Inventor 林国华林建国张铁民
Owner SHENZHEN ZHONGNONG KEGONG VENTURE ASSET MANAGEMENT CO LTD
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