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Preparation method of antibacterial adhesive coating layer on surface of stainless steel medical equipment

An anti-bacterial adhesion and medical device technology, applied in coatings, metal material coating processes, polyether coatings, etc. Membrane formation, the effect of resolving bacterial infections

Active Publication Date: 2016-05-04
武汉迪赛新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research has confirmed that bacteria will quickly form a layer of biofilm on the surface of the material after they adhere to the surface of the material. The current sterilization and disinfection methods can kill the living bacteria adhered to the surface of the material, but it is difficult to destroy this layer of biofilm. Therefore, the bacteria coated in this layer of biofilm are difficult to kill, which often leads to secondary infection at the implantation site
Chinese patent application 201510018201 reports a biologically safe antibacterial passivation solution and passivation process on the surface of medical stainless steel. The invention achieves antibacterial purposes by introducing copper ions into the passivation solution, but it cannot inhibit bacteria on its surface. Therefore, it cannot inhibit the formation of biofilm, which is essentially the same as the traditional sterilization treatment, and copper ions have potential biological toxicity

Method used

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  • Preparation method of antibacterial adhesive coating layer on surface of stainless steel medical equipment
  • Preparation method of antibacterial adhesive coating layer on surface of stainless steel medical equipment
  • Preparation method of antibacterial adhesive coating layer on surface of stainless steel medical equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] First, 316L stainless steel is made into a disc with a thickness of 1 mm and a diameter of 15 mm, and an anti-bacterial adhesion coating on the surface of the stainless steel is prepared according to the method in the summary of the invention.

[0032] The aminosilane used in step (2) is 3-aminopropyltriethoxysilane, the concentration of the toluene solution of 3-aminopropyltriethoxysilane is 5v / v%, soak for 15 minutes;

[0033] used in step (3) The compound is 2-chloropropionyl chloride, and the concentration of its nitromethane solution is 0.2v / v%;

[0034] The degree of polymerization of polyethylene glycol in the polyethylene glycol monoester methacrylate used in the step (4) is 3, the catalyst is cuprous chloride, and the concentration of the polyethylene glycol monoester methacrylate aqueous solution is 4 wt%.

[0035] Its anti-bacterial adhesion was tested as follows.

[0036] The 316L stainless steel disc with a thickness of 1mm and a diameter of 15mm is used...

Embodiment 2

[0046] Firstly, 316L stainless steel is made into a disc with a thickness of 1 mm and a diameter of 15 mm, and then an anti-bacterial adhesion coating on the surface of the stainless steel is prepared according to the method in the summary of the invention.

[0047] Wherein, the aminosilane used in step (2) is 3-aminopropyltrimethoxysilane, and the concentration of the toluene solution of 3-aminopropyltrimethoxysilane is 10v / v%, soaked for 30 minutes;

[0048] used in step (3) The compound is 2-chloropropionyl chloride, and the concentration of its nitromethane solution is 1.0v / v%;

[0049] The degree of polymerization of polyethylene glycol in the polyethylene glycol monomethacrylate used in step (4) is 6, the catalyst is cuprous chloride, and the concentration of the polyethylene glycol monomethacrylate aqueous solution is 5 wt%.

[0050] The coating prepared in this embodiment is to the OD of Staphylococcus aureus 600 The value is 0.38, the control group is 0.95, the p v...

Embodiment 3

[0052]Firstly, 316L stainless steel is made into a disc with a thickness of 1 mm and a diameter of 15 mm, and then an anti-bacterial adhesion coating on the surface of the stainless steel is prepared according to the method in the summary of the invention.

[0053] Wherein, the aminosilane used in step (2) is 3-aminopropyltriethoxysilane, and the concentration of the toluene solution of 3-aminopropyltriethoxysilane is 4v / v%, soaked for 60 minutes;

[0054] used in step (3) The compound is 2-bromopropionyl bromide, and the concentration of its nitromethane solution is 0.4v / v%;

[0055] The polymerization degree of polyethylene glycol in the polyethylene glycol monoester methacrylate used in step (4) is 6, the catalyst is cuprous bromide, and the concentration of the polyethylene glycol monoester methacrylate aqueous solution is 2 wt%.

[0056] With the coating that present embodiment prepares to the OD of Staphylococcus aureus 600 The value is 0.32, the control group is 0.95...

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Abstract

The invention belongs to the technical field of high molecular material and metal surface treatment, and in particular, discloses a preparation method of an antibacterial adhesive coating layer on a surface of stainless steel medical equipment. The method comprises the following steps: (1) the surface cleaning is performed; (2) the surface amination is performed; (3) the stainless steel medical equipment after the surface amination is dip in nitromethane solution of a compound with a structural formula for reaction to form active reaction points on the surface; and (4) the stainless steel medical equipment treated in the step (3) is dip in water solution of methacrylic acid polyethylene glycol monoester; cuprous halide is added as catalyst to react by 24 hours at a room temperature; a polymethylacrylic acid macrogol ester antibacterial adhesive coating layer is formed on the surface of the stainless steel medical equipment; and the coating layer can stop bacteria from bonding the surface of the stainless steel medical equipment, so that the surface has functions of continuous bacteria resistance and biological corrosion prevention to prevent secondary pollution.

Description

technical field [0001] The invention relates to the technical field of polymer materials and metal surface treatment, in particular to a method for preparing an anti-bacterial adhesion coating on the surface of a stainless steel medical device. Background technique [0002] Stainless steel medical devices are widely used clinically, such as most surgical instruments and some surgical implants. These instruments must be sterilized before use to prevent postoperative infection. The current research has confirmed that bacteria will quickly form a layer of biofilm on the surface of the material after they adhere to the surface of the material. The current sterilization and disinfection methods can kill the living bacteria adhered to the surface of the material, but it is difficult to destroy this layer of biofilm. Therefore, the bacteria coated in this layer of biofilm are difficult to kill, which often leads to secondary infection of the implant site. Chinese patent applicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/02C09D4/02C09D171/02
CPCC09D4/00C09D171/02C23C22/02C23C2222/20
Inventor 陆飚
Owner 武汉迪赛新材料有限公司
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