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Fluorescent probe and detection method for detection of methamphetamine or/and ketamine

A fluorescent probe and fluorescence technology, applied in the fields of organic synthesis and fluorescence sensing, can solve the problems of inability to meet the needs of on-site real-time detection, time-consuming, complicated pre-processing, etc. The effect of alkalizing treatment

Active Publication Date: 2016-05-04
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another example is an article published on SensorsandActuators using fluorescence-enhanced method to detect methamphetamine: (FuY, ShiL, ZhuD, et al. -7), although this method avoids some drawbacks of liquid-phase fluorescence detection, the pre-processing is complicated and time-consuming, and cannot meet the needs of on-site real-time detection

Method used

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  • Fluorescent probe and detection method for detection of methamphetamine or/and ketamine
  • Fluorescent probe and detection method for detection of methamphetamine or/and ketamine
  • Fluorescent probe and detection method for detection of methamphetamine or/and ketamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Synthesis of 8BA-2F and Preparation of Sensing Thin Film

[0040]

[0041] Under nitrogen protection, compound 2 (0.62g, 0.4mmol), 4-hydroxymethylphenylboronic acid (0.73g, 4.8mmol), Pd(PPh 3 ) 4 (116mg, 0.1mmol), K 2 CO 3Aqueous solution (12mL, 2M), tetrahydrofuran 20mL, heated to reflux for 72 hours. Pour into 50mL saturated brine, and extract three times with tetrahydrofuran. Anhydrous MgSO for organic phase 4 dry. Column chromatography and recrystallization gave a white solid (0.35g, yield50%).

[0042] 1 HNMR (500M, CD 3 SOCD 3 ,ppm)δ8.54(s,4H),7.74(d,4H,J=8Hz),7.70(d,8H,J=8Hz),7.62(m,12H),7.57(s,4H),7.54( d, 4H, J=8Hz), 7.54(d, 4H, J=8Hz), 7.39(t, 16H, J=8Hz), 5.20(dt, 8H, J=18Hz), 4.55(t, 16H, J= 6Hz), 4.20(s,4H), 1.93(s,4H), 1.84(s,4H), 1.52(s,4H), 1.36(s,4H), 1.01(s,8H), 0.51(s,4H ),0.32(s,4H); 13CNMR(500MHz,CD 3 SOCD 3 ,ppm)δ151.03,141.55,140.63,139.78,139.31,138.91,138.80,130.91,126.96,126.89,126.37,126.16,125.44,124.54,122.81,120.70,120.17,1...

Embodiment 2

[0048] Interaction of 8BA-2F with methamphetamine (group A19)

[0049] Prepare a sensing film according to Example 1. A methamphetamine solution was dropped onto the sensing film and tested after it dried. Comparing the absorption and fluorescence spectra of the sensing film before and after dropping, it can be seen that the absorption spectrum basically does not change, while the fluorescence spectrum peak blue shifts from about 470nm to about 400nm.

Embodiment 3

[0051] Interaction of 8BA-2F with K powder (group A19)

[0052] Prepare a sensing film according to Example 1. Drop the K powder solution onto the sensing film, and test it after it dries. Comparing the absorption and fluorescence spectra of the sensing film before and after the dropwise addition, it can be seen that the absorption spectrum does not change substantially, and the fluorescence spectrum peak is blue-shifted from about 470nm to about 400nm. It can be found in Comparative Example 2 that the probe is compatible with methamphetamine and ketamine The change of the fluorescence emission peak after the action is basically the same.

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Abstract

The invention relates to a fluorescent probe and detection method for detection of methamphetamine or / and ketamine. The fluorescent probe is characterized in that it is a substance composed of an aryl methyl alcohol structure and can emit fluorescence. The detection method consists of: preparing a solution of the probe, coating a substrate surface with the solution, and performing volatilization to remove the solvent so as to obtain a sensing film; and dropping a to-be-detected methamphetamine or ketamine solution to the sensing film surface directly, contrasting the fluorescence color and brightness change before and after dropwise adding, thus realizing detection of methamphetamine or ketamine. Specifically, Ar is a group selected from A1-A20. The detection method provided by the invention has the advantages of quick and sensitive detection reaction, the whole detection process can be realized within a few seconds, and the detection process has no need of adding any auxiliary reagent, thus avoiding background interference and reagent pollution. The probe can react with drugs to cause the change of the absorption and fluorescence spectrum of the material, and whether drugs exist can be determined according to the spectral signal change, also the drug concentration can also be determined according to the change degree, thereby realizing qualitative and quantitative detection of drugs.

Description

technical field [0001] The invention relates to a fluorescent probe and a detection method for detecting methamphetamine or / and ketamine, in particular to a fluorescent probe and a method for trace detection of methamphetamine (ice) or / and ketamine (K powder). The invention belongs to the technical field of organic synthesis and the field of fluorescent sensing. Background technique [0002] The current drug situation is becoming more and more severe, and the global drug manufacturing, trafficking, and abuse are becoming more and more serious. The number of drug addicts in the world has exceeded 200 million. In 2014, the overall situation of drug abuse showed that the rapid spread of traditional drugs represented by heroin was further curbed, and the number of abusers of synthetic drugs, mainly methamphetamine and ketamine, increased rapidly. [0003] Highly sensitive sensors are the technical guarantee for anti-drug and maintaining social stability. At present, the detecti...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/78C09K11/06C07D209/86
CPCC07D209/86C09K11/06C09K2211/1029G01N21/643G01N21/78
Inventor 范天驰贺庆国付艳艳曹慧敏程建功
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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