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Ciprofloxacin lactate gel for ears and preparation method of ciprofloxacin lactate gel

A technology of ciprofloxacin lactate and gel, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can solve the problems of difficulty in uniform coating, clinical application limitations, volatile, Problems such as fluid flow, to achieve the effect of good stability, beautiful appearance, and easy absorption

Inactive Publication Date: 2016-05-11
SHAANXI SHENGMAI PETROLEUM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound ciprofloxacin ear drops are mainly used to treat acute and chronic suppurative otitis media, otitis externa, and tympanitis, but it is not easy to spread evenly, and is easy to volatilize and disperse, so the clinical application is limited to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Ciprofloxacin Lactate Otic Gel, consisting of the following ingredients:

[0020] Ciprofloxacin lactate 0.5-1g;

[0021] Propylene glycol 10-15mL;

[0022] Ethanol 20-25mL;

[0023] CMC-Na0.5-1.0g; Carbomer 9400.5-1g;

[0024] Purified water 100g.

[0025] The preparation method of ciprofloxacin lactate otic gel comprises the following steps:

[0026] (1) Add 1g of Carbomer 940 to 10mL of propylene glycol, grind it evenly in a mortar, add 15mL of water to make it fully swell;

[0027] (2) Add 0.5g of ciprofloxacin lactate into 15mL of purified water, stir to dissolve completely;

[0028] (3) Take 1.0g of CMC-Na, wet it with ethanol, add 15mL of purified water, and stir to form a paste;

[0029] (4) Mix the product of step (2) and step (3), stir well and incorporate into the product of step (1), add purified water to 100g, add acetic acid dropwise to adjust the pH to 6.0, stir well to obtain a milky white gel ;

[0030] (5) The above-mentioned milky white gel is ...

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PUM

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Abstract

The invention relates to the technical field of medicine preparation, in particular to ciprofloxacin lactate gel for the ears and a preparation method of the ciprofloxacin lactate gel. The ciprofloxacin lactate gel comprises 0.5-1g of ciprofloxacin lactate, 10-15mL of propylene glycol, 20-25mL of ethanol, 0.5-1.0g of CMC-Na, 0.5-1g of Carbomer 940 and 100g of purified water. The ciprofloxacin lactate gel for the ears is simple in preparation process, attractive in property, easy in coating, easy to absorb after local administration, capable of avoiding clothes contamination and good in stability.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a ciprofloxacin lactate ear gel and a preparation method thereof. Background technique [0002] Ciprofloxacin is a quinolone antibacterial drug with strong pharmacological activity. It is mainly used for genitourinary system infection, respiratory tract infection and gastrointestinal tract infection caused by sensitive bacteria. Compound ciprofloxacin ear drops are mainly used for the treatment of acute and chronic suppurative otitis media, otitis externa, and tympanic myringitis, but it is not easy to apply evenly, and it is easy to volatilize and disperse, so its clinical application is limited. Gel for external use is transparent and semi-solid, uniform and delicate in texture, easy to apply, can form a transparent film on the skin, strong adhesion, fast drug release, long residence time, no stuffy, greasy feeling, easy to wash and remove, no pollution Clothing, ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/496A61K47/38A61P31/04A61P27/16
CPCA61K9/0046A61K9/06A61K31/496A61K47/38
Inventor 王耀斌
Owner SHAANXI SHENGMAI PETROLEUM
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