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Compound preparation for treating dairy cow mammitis and preparation method thereof

A compound preparation and mastitis technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve the problems of general effect, skin irritation, limited clinical application, and complex traditional Chinese medicine ingredients. , to achieve the effect of good effect, less resistance to drug resistance and controllable quality

Inactive Publication Date: 2016-05-11
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Early studies on transdermal penetration enhancers were mostly limited to organic solvents such as propylene glycol, dimethylformamide, dimethyl sulfoxide, etc. These compounds were used at higher concentrations, among which dimethyl sulfoxide had the best penetration-promoting effect, but Its toxicity and skin irritation limit its clinical application
At present, chemical penetration enhancers such as azone are mostly used. In recent years, azone has been widely used in external preparations of drugs, and has played an important role in improving therapeutic effects, reducing adverse reactions of drugs, and developing new varieties of preparations. The traditional Chinese medicine transdermal penetration enhancer has a general effect because of the complex ingredients of traditional Chinese medicine

Method used

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  • Compound preparation for treating dairy cow mammitis and preparation method thereof
  • Compound preparation for treating dairy cow mammitis and preparation method thereof
  • Compound preparation for treating dairy cow mammitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Formula of compound ointment (W / W): The formula and source of main ingredient essential oil are shown in Table 1.

[0021] Table 1

[0022]

[0023] 2. Preparation of compound ointment:

[0024] 2.1 Through many years of tests and applications, the formula (weight ratio) of the best compound ointment excipients has been determined as: stearic acid 1, glycerin 2, glyceryl monostearate 0.1, ethylparaben 0.1, dodecyl Sodium Alkyl Sulfate 1, Vaseline 0.05, Distilled Water 10.

[0025] 2.2 According to the ratio of essential oils in Table 1, the ratio of total essential oils to total ointment excipients is 1:1 (W / W).

[0026] 2.3 Preparation method: under sterile conditions, weigh various essential oils in proportion, heat on a water bath, and keep warm in a water bath at 70-80°C for 0.5 hours. In addition, take all the ingredients in the auxiliary materials and add them together, heat them in a water bath until they melt, add the liquid slowly to the essential oil ...

Embodiment 2

[0028] In vitro antibacterial test:

[0029] In order to evaluate the antibacterial effect of the three essential oils and their compounds, and to screen the drug formulations, the antibacterial test of the essential oils and compound essential oils was carried out.

[0030] 1. Materials and methods:

[0031] 1.1 Test drugs:

[0032] Test samples 1, 2, and 3 were all prepared by the New Veterinary Drug Engineering Laboratory of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, and prepared according to the purchased essential oils in Table 1, and prepared in different proportions without adding excipients. Control drug: Rulining (Shuangding injection), produced by Hebei Yuanzheng Pharmaceutical (production batch number 20131622).

[0033] 1.2 Isolation and identification of the pathogenic bacteria of dairy cow mastitis:

[0034] 1.2.1 Collection of samples:

[0035] The milk samples were collected from a dairy farm in ...

Embodiment 3

[0052] Anti-inflammatory test:

[0053] No matter the clinical type or recessive cow mastitis, its clinical manifestations and symptoms are all inflammatory reactions. Inflammation is the direct cause of udder damage and decreased milk production. Many traditional Chinese medicines have non-specific anti-inflammatory effects and relieve clinical symptoms. The anti-inflammatory effect of traditional Chinese medicine is also an important part of the anti-infective mechanism of traditional Chinese medicine. Therefore, the anti-inflammatory effect of traditional Chinese medicine is an essential indicator, so the anti-inflammatory test of the drug was carried out.

[0054] 1. Experimental animals and methods:

[0055] 30 Kunming mice, both male and female, were reared and observed for 7 days, and 20 healthy mice weighing 30±2g were randomly divided into 2 groups, 10 in each group, respectively numbered, group 1 was the control group, and group 2 was test group. Dip a cotton sw...

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Abstract

The invention discloses a compound preparation for treating dairy cow mammitis. The compound preparation is prepared from, by weight, 1 part of lavender essential oil, 1-2 parts of cinnamon essential oil, 1-3 parts of wild marjoram essential oil and 3-6 parts of auxiliary materials. A preparation method of the compound preparation is provided. The compound preparation and the preparation method have the advantages that the plant essential oil is adopted as effective ingredients, the good effects of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation are achieved, the effect of treating dairy cow mammitis is extremely good, and due to the adoption of the pure traditional Chinese medicine preparation and no chemical drug ingredient is contained, the safety of dairy products is facilitated. Uniform solids are obtained through stirring, stable performance and controllable quality are achieved, and industrial production is well facilitated. The compound preparation serves as traditional Chinese medicine, the effect of the compound preparation is definite, no residue or toxic or side effect is generated, the compound preparation can be used in a lactation period and can become good substitute goods of antibiotics, and the obtained traditional Chinese medicine compound ointment has high application value in veterinary clinical medicine.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a compound preparation for treating cow mastitis and a preparation method thereof. Background technique [0002] The most common cause of mastitis in dairy cows is that pathogenic microorganisms invade the mammary glands through the teat ducts of cows. Inflammation of the mammary glands. According to reports, there are more than 150 kinds of pathogenic microorganisms that cause mastitis in dairy cows, and more than 20 kinds are more common. Among them, Staphylococcus aureus and Streptococcus are widely spread in the world, accounting for about 70% of the total cases of mastitis in cows. More than 90% of the cases in our country. [0003] Antibiotic therapy is still the most commonly used method to treat mastitis at home and abroad, and plays an important role in the comprehensive prevention and treatment of mastitis and control of milk quality. For clinical mastiti...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P15/14
CPCA61K36/54A61K9/0014A61K9/06A61K36/53A61K47/10A61K2300/00
Inventor 梁剑平郝宝成陶蕾刘宇郭文柱王学红尚若锋郭志廷赵凤舞杨珍陈虹贾忠
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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