Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof

A technology that warms the meridian, unblocks collaterals, activates blood circulation and removes blood stasis. It is applied in drug combinations, active ingredients of hydroxyl compounds, and pharmaceutical formulas. It can solve problems such as large toxic and side effects, strong dependence, and stimulation of the digestive nervous system, and improve product quality and dissolution. degree of effect

Inactive Publication Date: 2016-05-11
JILIN ZIXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many chemical drugs for the treatment of cardiovascular diseases, but they have the disadvantages of large toxic and side effects, strong dependence, stimulation of digestion and nervous system, and difficult to cure fundamentally.

Method used

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  • Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof
  • Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Made from the following raw materials in parts by weight:

[0029] 260 parts of Chuanxiong, 410 parts of Astragalus, 120 parts of Panax notoginseng, 120 parts of Guizhi, 40 parts of woody fragrance, 120 parts of hawthorn, 200 parts of salvia miltiorrhiza, 120 parts of Alisma, 40 parts of Sophora japonica, 120 parts of turmeric, 5 parts of borneol;

[0030] The preparation method of the active ingredient of the pharmaceutical composition of the present invention comprises the following steps:

[0031] (1) Take Rhizoma Chuanxiong in proportion, add 1% compound enzyme containing cellulase and pectinase, wherein the ratio of cellulase and pectinase is 1:1, add 1 times the amount of warm water, mix well, 40 Enzyme hydrolysis at ℃ for 1 hour; add water, extract once by steam distillation, collect volatile oil, filter the medicinal solution, combine the filtrates, concentrate with a flash evaporator, add a large amount of ethanol and let it stand overnight, centrifuge with a h...

Embodiment 2

[0043] Made from the following raw materials in parts by weight:

[0044] 280 parts of Chuanxiong, 430 parts of Astragalus, 140 parts of Panax notoginseng, 140 parts of Guizhi, 60 parts of woody fragrance, 140 parts of hawthorn, 220 parts of salvia miltiorrhiza, 140 parts of Alisma, 60 parts of Sophora japonica, 140 parts of turmeric, 6.5 parts of borneol.

[0045] The preparation method of the active ingredient of the pharmaceutical composition of the present invention comprises the following steps:

[0046] (1) Take Rhizoma Chuanxiong in proportion, add 5.5% compound enzyme containing cellulase and pectinase, wherein the ratio of cellulase and pectinase is 1:1, add 5.5 times the amount of warm water, mix, 50 Enzyme hydrolysis at ℃ for 3 hours; add water, extract 3 times by steam distillation, collect volatile oil, filter the liquid medicine, combine the filtrates, concentrate with a flash evaporator, add a large amount of ethanol and let it stand overnight, centrifuge with a...

Embodiment 3

[0058] Made from the following raw materials in parts by weight:

[0059] 300 parts of Rhizoma Chuanxiong, 450 parts of Astragalus, 160 parts of Panax notoginseng, 160 parts of Guizhi, 80 parts of woody fragrance, 160 parts of hawthorn, 240 parts of salvia miltiorrhiza, 160 parts of Alisma, 80 parts of Sophora japonica, 160 parts of turmeric, 8 parts of borneol;

[0060] The preparation method of the active ingredient of the pharmaceutical composition of the present invention comprises the following steps:

[0061] (1) Take Rhizoma Chuanxiong in proportion, add 10% compound enzyme containing cellulase and pectinase, wherein the ratio of cellulase and pectinase is 1:1, add 10 times the amount of warm water, mix well, 60 Enzyme hydrolysis at ℃ for 5 hours; add water, use steam distillation to extract 5 times, collect volatile oil, filter the liquid medicine, combine the filtrates, use a flash evaporator to concentrate, add a large amount of ethanol to stand overnight, use a high...

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Abstract

The invention relates to a medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The medicinal composition comprises 260-300 parts of Ligusticum wallichii, 410-450 parts of Radix Astragali, 120-160 parts of panax notoginseng, 120-160 parts of cassia twig, 40-80 parts of Radix Aucklandiae, 120-160 parts of hawthorn fruit, 200-240 parts of Salvia miltiorrhiza, 120-160 parts of Rhizoma Alismatis, 40-80 parts of sophora flower, 120-160 parts of Radix Curcumae Aromaticae and 5-8 parts of borneol. The medicinal composition has the efficacy of activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, can be used to treat spirit dullness, hemiplegia, limb numbness, body cooling, unsmooth speech and other symptoms induced by cerebral thrombus and blood fat increase, and also has good effects on body temperature decrease, limb numbness and other symptoms; and a biological enzymatic hydrolysis, supercritical extraction, decoction and solvent normal temperature leaching technology combination extraction technology is adopted to extract raw materials with different qualities, so the dissolution of effective components of the medicines is greatly improved, and improvement of the quality of the above product is facilitated.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and specifically relates to a medicine with the functions of promoting blood circulation and removing blood stasis, warming meridians and dredging collaterals, and is used for treating mental sluggishness, hemiplegia, numbness of limbs, cold body, slow speech and other diseases caused by cerebral thrombosis and hyperlipidemia, and the medicine thereof. Preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular and cerebrovascular diseases, and generally refer to ischemic or hemorrhagic diseases in the heart, brain, and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and high blood pressure. . It has the characteristics of "high morbidity, high mortality, high disability rate, many complications, and high recurrence rate". Patients with cardiovascular and cerebrovascular diseases ha...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P25/00A61P9/00A61K31/045
CPCA61K36/9066A61K31/045A61K36/236A61K36/258A61K36/285A61K36/481A61K36/489A61K36/537A61K36/54A61K36/734A61K36/884A61K2236/19A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/55A61K2300/00
Inventor 荣梓清李雪郭春生殷金玲鲁敏
Owner JILIN ZIXIN PHARMA
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