Method for preparing hydroxyapatite/chitin composite porous scaffold materials
A technology of hydroxyapatite and hydroxyapatite powder, which is applied in the fields of medical science and prostheses, and can solve the problems of low fatigue resistance and damage resistance, poor conformity to bone tissue, and high brittleness.
Inactive Publication Date: 2016-05-11
SHAANXI YUHANG ELECTRONICS
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Problems solved by technology
The interpenetrating pore structure of porous hydroxyapatite can provide conditions for cell growth, tissue regeneration and vascularization, and is conducive to bone tissue growth, but its mechanical properties are poor, brittle, and its fatigue resistance and damage resistance are not strong in physiological environments. High, and the degradation in the body is slow, it cannot meet the requirements of bone tissue substitute materials well
Method used
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Experimental program
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specific Embodiment
[0011] Specific embodiments: the preparation process of the present invention includes two steps of preparation of hydroxyapatite powder and preparation of composite porous scaffold;
[0012] The preparation step of the hydroxyapatite powder is to configure Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 aqueous solution, adjust the pH value between 10 ~ 11, and then (NH 4 ) 2 HPO 4 The solution was slowly added to Ca(NO 3 ) 2 In the solution, stir well, and control the reaction temperature at 45°C. After reacting for 8 hours, a hydroxyapatite precipitate is obtained. After aging, cleaning, filtering, drying, heat treatment, grinding, and sieving, the obtained precipitate has a particle size of High-purity hydroxyapatite powder distributed within 1-10 μm;
[0013] The preparation step of the composite porous scaffold is: mix the hydroxyapatite powder and the foaming agent evenly, then place the treated organic foam carrier in the ceramic slurry to fully impregnate it evenly, and then...
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Abstract
The invention discloses a method for preparing hydroxyapatite / chitin composite porous scaffold materials, and belongs to the field of preparation of medical scaffold materials. The method includes taking high-purity hydroxyapatite powder synthesized by wet process as a matrix to prepare hydroxyapatite / B-tricalcium phosphate porous scaffolds by an organic foam impregnation-foam composite molding process; modifying the porous scaffolds by chitin to obtain the hydroxyapatite / chitin composite porous scaffold materials. The method for preparing the hydroxyapatite / chitin composite porous scaffold materials has the advantages that the hydroxyapatite / chitin composite porous scaffold materials are high in mechanical strength and are biocompatible; the porosity of the composite porous scaffolds prepared by the method ranges from 75% to 85%, the compressive strength of the composite porous scaffolds ranges from 0.9 MPa to 1.5 MPa, the composite porous scaffolds are biocompatible to a certain extent, and accordingly requirements on bone tissue substitute materials can be met.
Description
technical field [0001] The invention belongs to the field of preparation of medical bracket materials. Background technique [0002] Tissue engineering is a fringe subject that has emerged with the development of cell biology and biomaterials technology in the past 20 years. Its core is to establish a three-dimensional space complex of cells and scaffold materials, which is used to analyze the morphology and structure of diseased tissues. And functional reconstruction, and achieve a permanent replacement. Scaffold materials used in tissue engineering are the basis of tissue engineering and an indispensable link in tissue engineering. suitable external environment. [0003] Hydroxyapatite is the main component of bone. It has good biocompatibility and bioactivity, good osteoconductivity, non-toxic, non-irritating, good chemical stability and good corrosion resistance when used as bone implant material. With strong wear resistance, it is currently an important replacement m...
Claims
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IPC IPC(8): A61L27/56A61L27/40A61L27/20A61L27/12
Inventor 郝青
Owner SHAANXI YUHANG ELECTRONICS