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Trollius chinensis bunge effervescent granules and preparation method thereof

A technology of effervescent granules and nasturtium, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of water dispersion, reduce the stability of granules, and affect the effervescence effect, etc. , to increase the acid-base contact area, reduce the direct contact area, and solve the effect of large color difference

Inactive Publication Date: 2016-05-18
CHENGDE TIANYUAN PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current Trollius granules often have the problems of being relatively dispersed in water, often sinking to the bottom of the cup, and disintegrating for a long time, and the disintegration time is easily affected by the water temperature, and it takes a long time when the water temperature is low
And existing effervescent granules generally have the following defects: (1) the traditional acid-base granulation method, the contact area of ​​acid granules and alkali granules after entering the water is small, which seriously affects the effervescent effect; (2) the traditional acid-base granulation method respectively , there are differences in the color of acid-base granules, which affect the appearance of granules; (3) In the traditional acid-base granulation method, acid-base granules are easy to absorb moisture and cause acid-base reactions to generate gas, which is not conducive to product storage and transportation, and greatly reduces the stability of granules. sex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In the present embodiment, the effervescent granules of Trollius chinensis are prepared by the following method, which specifically includes the following steps:

[0038] Weigh 0.5kg of dried nasturtium flowers, add 6kg of pure water and decoct for 1.5h (calculated by boiling time), filter to obtain medicinal residues and filtrate; add 4kg of pure water to the medicinal residues and decoct for 1h (calculated by boiling time) , filter, discard the medicinal residues, and combine the filtrate twice; the filtrate is concentrated under reduced pressure to obtain an extract whose relative density is 1.1-1.2 (measured at 50°C), and 0.5kg of excipient mannitol is added to 0.25kg of the extract, mixed Uniformly, vacuum-dry at 50°C for 2 hours, pulverize, and sieve through 100 mesh to obtain medicinal powder, and set aside;

[0039] Weigh 10g of PEG-6000 and heat it to 75°C. After it is completely melted, transfer it to a 40°C water bath, add 15mL of absolute ethanol, stir well,...

Embodiment 2

[0043] In the present embodiment, the effervescent granules of Trollius chinensis are prepared by the following method, which specifically includes the following steps:

[0044] Weigh 2.0kg of dried nasturtium flowers, add 30kg of pure water and decoct for 1.5h (calculated by boiling time), filter to obtain medicinal residues and filtrate; add 4kg of pure water to the medicinal residues and decoct for 1h (calculated by boiling time) , filter, discard the medicinal residues, and combine the filtrate twice; the filtrate is concentrated under reduced pressure to obtain an extract whose relative density is 1.2-1.3 (measured at 50°C), and 500g of excipient lactose is added to 125g of the extract, mixed uniformly, 45 ℃ vacuum drying for 3 hours, pulverized, sieved through 100 mesh to obtain the medicinal powder, and set aside;

[0045] Weigh 10g of PEG-6000 and heat it to 80°C. After it is completely melted, transfer it to a 60°C water bath, add 15mL of absolute ethanol, stir evenly...

Embodiment 3

[0049] In the present embodiment, the effervescent granules of Trollius chinensis are prepared by the following method, which specifically includes the following steps:

[0050] Take by weighing 0.5kg of dried nasturtium flowers, add 5kg of pure water to decoct for 1h (calculated by boiling time), filter to obtain medicinal residues and filtrate; add 5kg of pure water to the medicinal residues and decoct for 2h (calculated by boiling time), Filter, discard the medicinal residues, and combine the two filtrates; the filtrate is concentrated under reduced pressure to obtain an extract whose relative density is 1.2-1.35 (measured at 50° C.), and 450 g of excipient dextrin is added to 150 g of the extract, mixed uniformly, 50 ℃, vacuum-dried for 2 hours, pulverized, and passed through a 100-mesh sieve to obtain the medicinal powder, which was set aside;

[0051] Weigh 10g of PEG-6000 and heat it to 70°C. After it is completely melted, transfer it to a 40°C water bath, add 15mL of a...

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Abstract

The invention provides trollius chinensis bunge effervescent granules and a preparation method thereof. The method comprises the following steps: decocting dried trollius chinensis bunge twice, filtering, and mixing the filtrates; concentrating the filtrate into extract having a relative density of 1.1-1.35, adding an excipient into the extract, uniformly mixing, and drying to obtain medicinal powder for later use; adding an effervescing agent which is a mixture of an acid source and a PEG-6000 coated alkali source into the medicinal powder, adding an adhesive, granulating, drying and finishing to obtain the trollius chinensis bunge effervescent granules. According to the method, the alkali source is coated with PEG-6000 by adopting an acid-alkali mixing granulation method, so that the direct contact area between the acid source and the alkali source can be greatly reduced, reaction generated when acid and alkali are directly contacted is prevented, the stability of the effervescent granules can be improved, the problems of large difference of granule colors, non-uniform mixing and easily layered acid-alkali granules in the method for respectively preparing acid and alkali can be solved, compliance of patients can be improved, and the curative effect of the trollius chinensis bunge effervescent granules can be guaranteed.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a trophyllus effervescent granule and a preparation method thereof. Background technique [0002] Effervescent granules are characterized by rapid disintegration in normal temperature water, convenient to take, good taste, fast absorption, convenient storage and transportation, so they are more and more popular with patients, especially suitable for children, the elderly and swallow Patients who have difficulty taking pills. Medicinal nasturtium is the dried flower of Trollius chinensis Bunge, a plant of the Ranunculaceae family. It has the effect of clearing away heat and detoxifying. infectious disease. There are many dosage forms of Trollius, among which Trollius Oral Liquid, Trollius Tablets, Trollius Capsules, Trollius Granules, and Trollius Lozenge Tablets have been included in the 2015 edition of "Chinese Pharmacopoeia". [0003] The current Trollius...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/16A61K47/34A61P11/04A61P27/16A61P27/02A61P11/00A61P31/00
Inventor 周印军于海霞闵向男于海燕吴艳楠
Owner CHENGDE TIANYUAN PHARMACEUTICAL INDUSTRY CO LTD
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