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Hydrolysis method of astilbin

A technology of astilbin and hydrolyzate, which is applied in the field of natural medicinal chemistry, can solve the problems of increased production costs, pollution, waste of resources and the environment, and achieve the effects of reducing waste of resources and environmental pollution, facilitating industrial production, and reducing production costs

Active Publication Date: 2016-05-18
SUZHOU HEYAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, this method uses a macroporous resin to separate and purify taxifolin, resulting in increased production costs, which is not conducive to industrial production; Li sugar is not separated and purified, and it is directly discharged as waste, resulting in a low utilization rate of astilbin; on the other hand, the acid used in the acid hydrolysis of this method cannot be recovered and recycled, causing problems such as waste of resources and environmental pollution. It is not conducive to the implementation of sustainable development strategy

Method used

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  • Hydrolysis method of astilbin

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Effect test

Embodiment 1

[0035] The hydrolysis method of astilbin in the present embodiment comprises the following steps of hydrolyzing astilbin to prepare taxifolin:

[0036] (1) Take 50 g of astilbin, add 350 mL of 2.5 mol / L citric acid aqueous solution under stirring, and hydrolyze at 90 °C for 3.5 h to obtain a hydrolyzed solution;

[0037] (2) filtering the hydrolyzate while hot, concentrating the filtrate to 200mL, standing for at least 12h, crystallizing, filtering, collecting the filter cake and the filtrate respectively, and the filter cake is the taxifolin crude product;

[0038] (3) The taxifolin crude product is recrystallized, and the specific conditions for recrystallization are as follows: the taxifolin crude product is dissolved in 40° C. water, and then cooled to room temperature to obtain taxifolin.

[0039] The hydrolysis method of astilbin in this embodiment also includes the following steps of hydrolyzing astilbin to prepare rhamnose: the above-mentioned filtrate is purified by A...

Embodiment 2

[0042] The hydrolysis method of astilbin in this embodiment includes the following steps of hydrolyzing astilbin to prepare taxifolin: (1) taking 50 g of astilbin, adding 500 mL of 1.5 mol / L citric acid aqueous solution under stirring, and hydrolyzing at 105°C for 3 hours, to obtain a hydrolyzate;

[0043] (2) the hydrolyzate was filtered while hot, the filtrate was concentrated to 190mL, left standing for at least 12h, crystallized, filtered, and the filter cake and the filtrate were collected respectively, and the filter cake was the taxifolin crude product;

[0044] (3) The taxifolin crude product is recrystallized, and the specific conditions of recrystallization are as follows: the taxifolin crude product is dissolved in 80° C. water, and then cooled to room temperature to obtain taxifolin.

[0045] The above filtrate is purified by AB-8 macroporous resin column chromatography, using water as the eluent, collecting the eluate, concentrating to Brix of 54-56%, and standing...

Embodiment 3

[0049] The hydrolysis method of astilbin in the present embodiment comprises the following steps of hydrolyzing astilbin to prepare taxifolin:

[0050] (1) Take 50 g of astilbin, add 750 mL of 1.0 mol / L citric acid aqueous solution under stirring, and hydrolyze at 115 °C for 2 h to obtain a hydrolyzed solution;

[0051] (2) filtering the hydrolyzate while hot, concentrating the filtrate to 210mL, standing for at least 12h, crystallizing, filtering, collecting the filter cake and the filtrate respectively, and the filter cake is the taxifolin crude product;

[0052] (3) The taxifolin crude product is recrystallized, and the specific conditions for recrystallization are as follows: the taxifolin crude product is dissolved in 60° C. water, and then cooled to room temperature to obtain taxifolin.

[0053] The hydrolysis method of astilbin in this embodiment also includes the following steps of hydrolyzing astilbin to prepare rhamnose: the above-mentioned filtrate is purified by AB...

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Abstract

The invention relates to a hydrolysis method of astilbin. The method for preparing texifolin by hydrolyzing astilbin comprises the following steps: taking 48-52 parts by weight of astilbin, adding 300-1050 parts by volume of a 0.5-2.8 mol / L citric acid water solution while stirring, and carrying out hydrolysis at 85-135 DEG C for 1.2-3.8 hours to obtain a hydrolysate; filtering the hydrolysate while the hydrolysate is hot, concentrating the filtrate to 180-220 parts by volume, standing for at least 12 hours, crystallizing, filtering, and respectively collecting the filter cake and the filtrate, wherein the filter cake is a texifolin crude product; and recrystallizing the texifolin crude product to obtain the texifolin. The method avoids using the macroporous resin for separating and purifying the texifolin, thereby lowering the production cost and being beneficial to industrial production. Another hydrolysate-rhamnose of the astilbin is separated and purified, thereby enhancing the utilization ratio of the astilbin. The acid used by hydrolysis can be recovered and recycled, thereby avoiding the problems of waste of resources, environmental pollution and the like.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, in particular to a hydrolysis method of astilbin. Background technique [0002] Taxifolin is one of the natural flavonoids active ingredients, has many important biological activities, can inhibit and activate a variety of enzymes, resulting in different physiological effects. Because it contains more phenolic hydroxyl groups, it has a strong antioxidant effect. Not only can it effectively eliminate excess free radicals from the human body, promote the permeability of capillaries, effectively restore the elasticity of capillaries, improve immune function, prevent the formation of inflammation and lumps, and reduce the occurrence of cancer; but also by inhibiting DGAT enzyme and MTP The activity of the enzyme reduces the secretion of apolipoprotein B to lower triglycerides and cholesterol in serum and hepatocytes. Clinically, Taxifolin has been used for the prevention and treatment of ...

Claims

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Application Information

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IPC IPC(8): C07D311/62
CPCC07D311/62
Inventor 夏增华
Owner SUZHOU HEYAN BIOTECH
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