The invention relates to a safe and efficient preparation method of an important raw material 9,9-dimethyl xanthene of an industrial catalyst Xantphos, and belongs to the technical field of fine chemical engineering. According to the preparation method, diphenyl ether, acetone and an acid catalyst serve as raw materials, a molar ratio of the raw materials is 1:1:(2-5), 9,9-dimethyl xanthene is prepared through a one-pot method, the yield can reach 70%-75%, and the content is 99% or above. According to the method, acid-catalyzed activated acetone and diphenyl ether are adopted for electrophilicsubstitution reaction to replace extremely dangerous trimethylaluminum and xanthone used in the traditional process for reaction, and the method has the characteristics of cheap and easily availableraw materials, safety in operation, high reaction speed, low requirements on production equipment and the like; and the production difficulty of the product is greatly reduced, and the yield of the 9,9-dimethyl xanthene can be rapidly increased.