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2-hydroxy-2-methyl-1-phenyl-1-propyl ketone synthesis process

A technology of propyl ketone and methyl, which is applied in the field of synthesis technology of 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone, can solve the problem of low production efficiency, unsuitability for large-scale production, process Problems such as difficult process, to achieve the effect of improving work efficiency, improving single-pass conversion rate and product yield, and overcoming many processes

Inactive Publication Date: 2016-06-08
吕艳
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AI Technical Summary

Problems solved by technology

In the current 2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone synthesis process method, the technical process is not easy to implement, and the generated 2-hydroxyl-2-methyl-1-phenyl-1 - The finished product of propyl ketone has low purity, low single-pass conversion rate of reactants, complex production process, low production efficiency and high cost, and is not suitable for large-scale production

Method used

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Embodiment

[0014] The synthetic technique of the 2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone of the present embodiment comprises the following steps:

[0015] ⑴Acylation: Put isobutyric acid into the reaction kettle, raise the temperature to 40°C, add phosphorus trichloride, keep it at 62°C for 4 hours, remove the inorganic layer to obtain isobutyryl chloride; the raw materials are isobutyric acid and phosphorus trichloride The weight ratio is 8:6.8;

[0016] (2) Friedel-Crafts reaction: Add benzene and catalyst aluminum trichloride to the reaction kettle, after cooling down to 15°C, drop isobutyryl chloride, benzene, aluminum trichloride and isobutyryl chloride in a weight ratio of 9:.4: 4.2, heat at 18°C ​​for at least 4.5 hours to obtain a complex of 2-methyl-1-phenyl-1-propyl ketone and aluminum trichloride;

[0017] (3) Hydrolysis reaction: add the complex compound into an appropriate amount of dilute hydrochloric acid with a mass concentration of 1.5%, stir and separate layers, r...

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Abstract

The present invention discloses a 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone synthesis process, which is characterized in that isobutyric acid is adopted as a raw material, an acylation reaction, a Friedel-Crafts reaction, and an alkaline hydrolysis reaction are performed to obtain a 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone crude product, and fine steaming is performed to obtain the 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone finished product. According to the present invention, the process is reasonable, no sulfur dioxide gas emits during the production process, the environmental pollution caused by the produced sodium chloride is low, and the product yield is high.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone. Background technique [0002] The synthesis process of 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone includes at least acylation reaction, chlorination reaction, cooling and other processes. In the current 2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone synthesis process method, the technical process is not easy to implement, and the generated 2-hydroxyl-2-methyl-1-phenyl-1 - The finished product of propyl ketone has low purity, low one-way conversion rate of reactants, complex production process, low production efficiency and high cost, and is not suitable for large-scale production. Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the purpose of the present invention is to provide a synthesis process of 2-hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/82C07C45/64
Inventor 吕艳
Owner 吕艳
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